Coagulation Cascade

Question 1

Basic Clot formation process

Answer 1

Injury to endothelium
Platelets form plug on exposure to collagen
Fibrinogen converts to fibrin strands and forms mesh around platelet plug, stabilising it. Exposure to TF in the damaged endothelium activates this

Question 2

Pathway that amplifies Thrombin production

Answer 2

Intrinsic pathway

Question 3

Pathway that initiates Thrombin production

Answer 3

Extrinsic pathway