Coagulation

Question 1

Hageman factor

Answer 1

Factor 12 ,glass factor

Question 2

Name the prothrombin activator

Answer 2

Phospholipid,ca,factor 5a,10a,

Question 3

Which are the steps which are independent of ca

Answer 3

1.conversion of factor 12-12a
2.factor 11-11a

Question 4

Among extrinsic and intrinsic which is the fastest

Answer 4

Extrinsic (15 sec )

Question 5

Which constituent convert soluble fibrinogen to insoluble fibrin

Answer 5

Thrombin

Question 6

What is the function of gamma carboxylation

Answer 6

Gamma carboxylation of factor 2,7,9,10
Essential for the ability of the factors to bind with Ca and with phospholipid necessary for the coagulation sequence to proceed

Question 7

Factors accelerate clot retraction

Answer 7

Thrombin
Ca

Question 8

Contractile protein necessary for clot retraction

Answer 8

Platelet thrombostenin
Actin
Myosin

Question 9

Function of PDGF (platelet derived growth factor ) after clot retraction

Answer 9

Stimulate fibroblast and smooth muscle to proliferate and replaces the damaged blood vessel

Question 10

How does plasmin help in float lysis

Answer 10

By the dissolution of fibrin

Question 11

Site of production of thrombo modulin

Answer 11

All the endothelial cell except the in the cerebral micro circulation

Question 12

Which are the types of plasminogen activator factors

Answer 12

1.tissue plasminogen factor (vascular endothelium )
2.urokinase type activation factor (endothelial cell,renal ,macrophages )

Question 13

Which is the tissue plasminogen activator produced by rDNA tech

Answer 13

Alteplase

Question 14

Which are the 4 circulating anti coagulant

Answer 14

1.heparin
2.protein c
3.anti thrombin 3
4.alpha 2 micro globulin

Question 15

Which cells produce heparin

Answer 15

Mast cells and basophils

Question 16

Name a parentral anti coagulant

Answer 16

Heparin

Question 17

Which act as the anti dote against heparin

Answer 17

Protamine sulphate

Question 18

Write example for oral in Vivo anti coagulant

Answer 18

Coumarin derivatives ,vit k antagonist
Warfarin
Dicumarol

Question 19

Name a test for primary hemostasis

Answer 19

Bleeding time

Question 20

Which are the condition where bleeding time increase

Answer 20

1.thrombocytopenic purpura
2.thrombestinin
3.vw disease

Question 21

Half life of platelet

Answer 21

8-12 days