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!!!!! Pharm Spring 16 Exam 2 !!!!! > CNS/Receptors > Flashcards

CNS/Receptors Flashcards

1
Q

_______ work on receptors to evoke a biological response, while ________ interferes with that response at the receptor site

A

Agonists

Antagonists

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2
Q

Natural Catecholamines: Agonists

A

Epinephrine

Norepinephrine

Dopamine

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3
Q

Synthetic Catechocholamines: Agonists

A

Isoproterenol

Dobutamine

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4
Q

example of an antagonist

A

beta adrenergic blocker

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5
Q

Post synaptic ONLY receptors

A

Alpha 1

Beta 1

Dopamanergic 1

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6
Q

Pre AND post synaptic receptors

A

Alpha 2

Beta 2

Dopamanergic 2

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7
Q

NOREPI > epi > isoproterenol

A

Alpha receptors

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8
Q

ISOPROTERINOL > epi > norepi

A

Beta receptors

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9
Q

activation causes VASOCONSTRICTION and RELAXATION of the GI tract

A

Postsynaptic Alpha 1 receptors

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10
Q

were are alpha 1 receptors found?

A

Postsynaptic

  1. Vasculature
  2. Heart
  3. Glands
  4. Gut
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11
Q

activation causes inhibition of NE release and inhibition of sympathetic outflow leading to decreased BP and HR and inhibition of CNS activity

A

Presynaptic

  1. Alpha 2 receptors
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12
Q

Found in: Peripheral vascular smooth muscle Coronaries Brain

A

Presynaptic

  1. Alpha 2 receptors
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13
Q

Found in: Coronaries CNS

A

Postsynaptic

  1. Alpha 2 receptors
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14
Q

Activation causes constriction, sedation and anesthesia

A

Postsynaptic

  1. Alpha 2 receptors
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15
Q

where are Postsynaptic Beta 1 receptors found

A
  1. Myocardium
  2. SA node
  3. ventricular conduction system
  4. coronaries
  5. kidneys
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16
Q

Activation causes coronary relaxation

A

Postsynaptic

  1. Beta 1
17
Q

where are Beta 2 receptors found?

A

Found in SMOOTH MUSCLE

  1. Vascular
  2. bronchiolar
  3. uterine skin
  4. myocardium
  5. coronaries
  6. kidneys
  7. GI tract
18
Q

uptake of potassium my the cells

19
Q

receptors that interact exclusively with dopamine

A

dopaminergic receptors

20
Q

Found on: Renal, mesenteric, splenic and coronary vessels and on renal tubules

A

Postsynaptic Dopamanergic 1 receptors

21
Q

cause vasodilation

A

Postsynaptic

  1. Dopamanergic 1 receptors
22
Q

activation causes inhibition of norepi release

A

Presynaptic

  1. Dopamanergic 2 receptors
23
Q

may promote constriction

A

Postsynaptic

  1. Dopamanergic 2 receptors
24
Q

3 areas with the highest concentration of Serotonin 5HT receptors

A
  1. wall of the intestine
  2. Blood
  3. CNS - this is where medications act
25
Q

insulin release gluconeogenesis

26
Q

vasodilation uterine relaxation bronchodilation

27
Q

Activation causes renin release, increases inotropy, chronotropy, and myocardial conduction velocity

A

Postsynaptic Beta 1

28
Q

Activation causes increased inotropy

A

Postsynaptic Beta 1

29
Q

Activation causes increased chronotropy

A

Postsynaptic Beta 1

30
Q

Activation causes increased myocardial conduction velocity

A

Postsynaptic Beta 1

!!!!! Pharm Spring 16 Exam 2 !!!!! (11 decks)

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