CNS/Receptors Flashcards
_______ work on receptors to evoke a biological response, while ________ interferes with that response at the receptor site
Agonists
Antagonists
Natural Catecholamines: Agonists
Epinephrine
Norepinephrine
Dopamine
Synthetic Catechocholamines: Agonists
Isoproterenol
Dobutamine
example of an antagonist
beta adrenergic blocker
Post synaptic ONLY receptors
Alpha 1
Beta 1
Dopamanergic 1
Pre AND post synaptic receptors
Alpha 2
Beta 2
Dopamanergic 2
NOREPI > epi > isoproterenol
Alpha receptors
ISOPROTERINOL > epi > norepi
Beta receptors
activation causes VASOCONSTRICTION and RELAXATION of the GI tract
Postsynaptic Alpha 1 receptors
were are alpha 1 receptors found?
Postsynaptic
- Vasculature
- Heart
- Glands
- Gut
activation causes inhibition of NE release and inhibition of sympathetic outflow leading to decreased BP and HR and inhibition of CNS activity
Presynaptic
- Alpha 2 receptors
Found in: Peripheral vascular smooth muscle Coronaries Brain
Presynaptic
- Alpha 2 receptors
Found in: Coronaries CNS
Postsynaptic
- Alpha 2 receptors
Activation causes constriction, sedation and anesthesia
Postsynaptic
- Alpha 2 receptors
where are Postsynaptic Beta 1 receptors found
- Myocardium
- SA node
- ventricular conduction system
- coronaries
- kidneys