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Neuro Part I > CNS Pharmacology > Flashcards

CNS Pharmacology Flashcards

1
Q

NE - location of synthesis

A

locus ceruleus (pons)

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2
Q

DA - location of synthesis

A

ventral tegmentum, SNc (substantia nigra, midbrain)

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3
Q

5-HT - location of synthesis

A

raphe nucleus (pons, medulla, midbrain)

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4
Q

Ach - location of synthesis

A

basal nucleus of Meynert

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5
Q

GABA - location of synthesis

A

nucleus accumbens

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6
Q

NE - increased

A

anxiety

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7
Q

NE - decreased

A

depression

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8
Q

DA - increased

A

Huntington dz

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9
Q

DA - decreased

A

Parkinson dz, depression

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10
Q

ACh - increased

A

Parkinson dz

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11
Q

ACh - decreased

A

Alzheimer dz, Huntinton dz

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12
Q

GABA - increased

A

none

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13
Q

GABA - decreased

A

anxiety, Huntington dz

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14
Q

Antidepressants - Neurogenesis Hypothesis

A
  • depression results from impaired hippocampal neurogenesis
  • antidepressants (ADs) -> increase monoamine neurotransmitters -> increase hippocampal neurogenesis and decrease neuronal cell death + restores synapses
  • explains lag in clinial efficacy of ADs, effect of stress on brain, increase of hippocampal vol
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15
Q

Glutamate +/- and Receptors

A

majority of excitatory (+) synapses in CNS

ionotropic - KAR, AMPAR, NMDAR (Mg2+ blocking, must bind glycine too)

metabotropic - mGluR 1 and 2

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16
Q

GABA +/– and Receptors

A

majority of inhibitory (–) synapses in CNS

ionotropic - GABAa (permeable to Cl–)

metabotrobic - GABAb (increase K+ conductance and hyperpolarize the cell)

17
Q

Catecholamine Synthesis

A

tyrosine

(tyrosine hydroxylase)

dopa

(dopa decarboxylase)

dopamine

(dopamine B-hydroxylase)

norepinephrine

(phentolamine N-methyltransferase)

epinephrine

18
Q

Dopamine Receptors

A

metabotropic DA receptors

19
Q

NE Recpetors

A

a1 = + phospholipase C

a2 = – adenyl cyclase

B = stimulate adeny cyclase

20
Q

Serotonin Synthesis

A

tryptophan

(tryptophan hydroxylase)

5-hydroxytryptophan

(L-amino acid decarboxylase)

serotonin

Neuro Part I (8 decks)

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