CNS Pharm Flashcards
Describe Action Potential
Channels in part of the cell open, positive ions in, negative out
- part of cell becomes positive
- channels start opening like dominoes
- at endo of nerve at nerve terminal neurotransmiters are released
Muscle Fiber innervated by
positive charges not neurotransmiter
action potential through a nerve is refered to as
synaptic potential
Effect of Ca on synaptic vesicles
Ca caused vessicles to fuse to the presynaptic membrane & release neurotransmitter stored in vesicles into the synapse
Once vessicles fuse neurotransmiters…
diffuse across synaptic space and bind to receptors, this changes post synaptic cells permability to ions
Excitatory Postsynaptic Potential
Post-synaptic cell gets excited and fires an action potential and this propagate excitation down the nerve. Called depolarization
Inhibitory Postsynaptic Action Potential
Neurotransmitter binding causes cell have a more negative charge and so cell is more resistant to depolarization
2 places of synapse drugs work at
- Presynaptic: synthesis, storage, metabolism, and release
- Post synaptic- on receptor (agonist or antagonist)
Parkinson Pathology
Too little Dopamine
6 Neurotransmiters
-Amino Acids
-Acetylcholine
Monoamines
Peptides
Nitric Oxide
Endocannabinoids
2 Amino Acids
- Glutamate
- GABA
3 Monoamines
- Epi
- NE
- Serotonin
DEA Number
Needed for Prescribing Controlled Substances
Schedule Range
1-5
Schedule 1
Extremely addictive, Heroin, LSD, PCP, high potential for abuse
