CNS Infections Flashcards
1
Q
3 pathways to enter CNS
A
Transcellular
Paracellular
Carriage w/in transmigrating leukocyte
2
Q
Pathogens:
Transcellular
A
E.coli
Group B streptococcus
3
Q
Paracellular
A
Protozoa
4
Q
Carrier
A
HIV
Mtb
L.monocytogenes
Strep suis
5
Q
E.coli
Facilitate EC binding
A
Type 1 fimbriae
OmpA
6
Q
E.coli
Invasion (4)
A
FAK
Paxcillin
PI3K
Akt/protein kinase B
7
Q
E.coli
Activates Rho GTPase, increase in vitro uptake of bacteria by phagocytes
A
CNF-1
8
Q
E.coli
Prevents maturation of endosomes & fusion of vacuoles with lysosomes
A
K1 capsule
