CNS - HN - Syncope Flashcards

1
Q

Differentials of Syncope

A
  1. Prolonged QT syndrome
  2. Aortic Stenosis
  3. Vasovagal
  4. Postural orthostatic hypotension - polypharmacy
  5. Postural orthostatic hypotension
  6. Postural orthostatic hypotension with Stroke
  7. Seizure due to binge drinking
  8. Diabetic Neuropathy
  9. Hypoglycemia
  10. TIA
  11. Seizure and subdural hematoma
  12. Seizure - idiopathic epilepsy
  13. Comatose
1. CNS - 
SAH
TIA/STROKE (case)
Epilepsy
Migraine 
Meningitis 
Seizure
2. CVS- 
HOCM
Arrythmias 
WPW
Aortic Stenosis (case)
Prolonged QT (case)
  1. Vasovagal - case
    Long standing

4.Reflex-micturition, defecation, cough syncope

  1. Orthostatic Hypotension - case
    polypharmacy
6. Metabolic 
Hypoglycemia - case 
Electrolyte imbalance (decreased K, Mg, Ca)
7. Medications
Drug-induced: side effect of antipsychotic (most common cause)
Abnormal Prolonged QT Syndrome Drugs
•	Amiodarone
•	Procainamide
•	Quinidine
•	Tricyclic antidepressants/Antipsychotic
•	Sotalol
•	Dizopyramide
  1. Trauma
  2. Malignancy
  3. Psychogenic
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2
Q

Differentials of Syncope

CNS

A
1. CNS - 
SAH
TIA/STROKE (case)
Epilepsy
Migraine 
Meningitis 
Seizure
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3
Q

Differentials of Syncope

CVS

A
2. CVS- 
HOCM
Arrythmias 
WPW
Aortic Stenosis (case)
Prolonged QT (case)
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4
Q

Key history - SYNCOPE / FALL

A

A careful history is required including an interview with family members and any witnesses to the fall.
Investigate the onset, environment and circumstances of the fall.
Consider seizure and loss of consciousness, and situational factors such as rushing to bathroom, climbing stairs or ladder. Incl. accounts of any witnesses to the fall.
Questions should incl. any premonitory or associated symptoms e.g. vertigo, lightheadedness, palpitations, chest pain dyspnoea, visual disturbance, possible unusual or disturbed behaviour.
Gather past and recent medical history incl. diabetes, hypertension, cerebrovascular disease; as well as a drug history, esp. alcohol or illicit drugs, prescription agents esp. sedatives antidepressants, hypotensives, hypoglycaemics, antipsychotics, diuretics, NSAIDs. Check thyroid status.

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5
Q

Key Physical examination - SYNCOPE / FALL

A

Key examination
•General features: appearance of patient incl. central cyanosis, hydration status, vital signs incl. pulse, BP (supine and standing) and temperature
•Look for and exclude obvious extrinsic causes of falls
•Comprehensive CVS examination
•Examine ears, eyes, oral cavity, head and neck, spine, extremities esp. feet
•Neurological examination including muscle features, sensation, coordination, balance and gait
•Mini mental state examination

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6
Q

Key Investigation - SYNCOPE / FALL

A
First line: 
•urinalysis
•blood sugar
•pulse oximetry 
•FBE & ESR
•U&E
•ECG (or 24 hour monitor). 
Consider others according to history and findings:
•LFTs (γGT)
•TFT
•echocardiography
•spinal X rays
•CT or MRI if indicated
•Doppler studies
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7
Q

Diagnostic Tips

A

Consider rules of 7 in elderly patient:

  1. check mental status
  2. eyes
  3. ears
  4. mouth (?dentition, xerostomia)
  5. bladder and bowels,
  6. locomotion including feet
  7. medication.

Ideally, visit the home to assess patient’s environment and home support, incl. examination of the medicine cabinet.

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8
Q

Prolonged QT - Management

A

Investigations
- FBE, UE, BSL, betaHCG, TFT, LFT, Chest XRay, ECG.

Treatment:

  • Admit
  • Refer to Cardiologist/ Registrar
  • Beta blocker if fails put on pacemaker
  • I will also arrange a family screening for this condition (only say this if congenital)
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9
Q

Aortic Stenosis - Management

A

Investigations:
- FBE, UEC, ESR/CRP, LFT, RFT, TFT.
- ECG, and chest x-ray,
echocardiogram.

Treatment

  • Admit to hospital
  • Seen by specialist
  • LSM - SNAP
  • Avoid strenuous activity
  • Surgery - Valve replacement
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10
Q

Vasovagal - Management

A

Investigations

  • FBE, UCE, LFT, TFT, BSL,
  • ECG
  • Admit for observation
  • Seen by registrar
  • Do’s & Don’ts
  • Don’t skip breakfast esp prior to activity/ avoid prolonged standing
  • Hydration
  • get up from sitting/lying slowly
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11
Q

POH - Management

A

Investigation

  • FBE, ESR,CRP, LFT, UCE, TFT, BSL, lipid, HbA1C,
  • ECG, echo
  • Admit for observation
  • Seen by specialist
  • Once discharged, refer back to DM physician/cardio for review of meds
  • Advise
    DM control
    IOF
    Get up slowly
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12
Q

POH Stroke - Management

A

Investigations

  • FBE, BSL, UCE, ESR CRP, - LFT, TFT,
  • Urinalysis
  • ECG, CT scan
  • Refer to fall clinic
  • MDT approach
  • Monitor VS regularly
  • Refer to Ophtha and ENT
  • Refer to physiotherapist
  • Refer to OT
  • Refer to Social worker
  • they might change medication dose accordingly
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13
Q

Seizure d/t Binge Drinking - Diagnosis

A
Condition - 
Binge drinking 
- imbalance of salt in body 
- dehydration 
- decrease sugar in body 

Common

Cause

Clinical feature

Complication

no management
*Ddx

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14
Q

Diabetic Neuropathy - Diagnosis

A

Condition -
DIabetic Neuropathy
high sugar» sensory loss

Common

Cause

Clinical feature

Complication

no management
*Ddx - vision problem, arthritis, mini stroke

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15
Q

Hypoglycemia - Diagnosis

A

Condition -
Hypoglycemia
BSL <4mmol

Common

Cause - MEDIKA 
Meds 
Exercise 
Diet 
Infection 
Kidney problems 
Alcohol 

Clinical feature
Mild
- hungry, sweaty, palpitation, shakes

Severe
- Loss of concentration, confusion, fits&raquo_space; LOC

Complication
- if left untreated coma&raquo_space; life threatening

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16
Q

Hypoglycemia - Management

A

Immediate management
If <4mmol/L, give 15 grams quick acting carbs

  • 6 jelly beans
  • tsp honey
  • 2 barley sugar
  • glass of lemonade

After 15 mins, repeat BSL
If still unwell, repeat

If still unwell, follow with a complex carbohydrate

  • sandwich
  • glass of milk
  • 1 pc of fruit

Severe cases

  • 20-30 ml 50% glucose IV until fully conscious
  • 1 ml Glucagon IM or SC
  • then send to hospital
o Preventive measures: 
	§ Avoid skip a meal. 
	§ Do not change your dose on your own. 
	§ Avoid any unplanned activity. 
	§ Do not binge drink. 
§Maintain a blood sugar diary, check your blood sugar every day.
  • Hypopack
  • ID Badge
  • 12 jelly beans
  • 6 glucose tablets ( 1 tab = 5 grams)
  • IM glucagon Injection
  • Refer to dietician
  • Refer to DM educator or nurse
  • Reading materials
  • Review
  • Red flags
  • Refer
17
Q

Transient Ischemic Attack - Management

A

Investigations

  • I will arrange for urgent CT scan and carotid Doppler
  • Need to do FBS, lipid profiles, FBE, UEC, LFTs, ECG, 2d-echo, TFTs, clotting profile, HbA1c
  • Refer to ED
  • Admit to stroke unit
  • Seen by neurologist
  • clopidogrel or ASA + Dipyridamol
  • LSM - SNAP
18
Q

Idiopathic Epilepsy - Diagnosis

A

Condition -
Idiopathic Epilepsy
problem with electrical circuit of brain and NS&raquo_space; unable to work properly

Common
1:100 M:F
familial

Cause
unknown

Clinical feature

Complication

19
Q

Idiopathic Epilepsy - Management

A
  • Aim of the treatment is to achieve complete seizure-control by one medication which is called monotherapy and lifestyle management
  • Monotherapy» dose adjusted 70-80%effective 1st line drugs»if fail, replaced by another drug» 1st drug is stopped once the therapeutic effect of the 2nd one is achieved.
  • LSM
  • avoidance of triggering factors like
  • fatigue
  • physical exhaustion
  • stress
  • lack of sleep
  • excess alcohol
  • avoidance of flashing lights
  • open fires

With proper treatment, most patients can achieve complete control of seizure and lead a normal life.

Meds
- Side effects: nausea, anorexia, vomiting, dizziness/drowsiness, tiredness or fatigue, gait disturbance like ataxia, visual disturbance, and most drugs can cause a rash.
o Sodium valproate: hair loss, rare but serious liver toxicity (LFTs every 2 months for 6 months after starting), NTD (spina bifida)
o Phenytoin: ginigival hyperplasia, hirsutism, fetal malformation (cleft lip and palate), CHD
Carbamazepine: anorexia, nausea, vomiting, dizziness, skin rash, tinnitus, diplopia, ataxia, tiredness and fatigue; safest in pregnancy

  • Reviewed annually, med stop if seizure free for 2-3 yrs
  • The applicant applying for learner’s license should be seizure-free for 2 years then annual review for 5 years.
    -contact centerlink, social support/worker; should not work close to heavy machinery, dangerous surroundings, heights, or near deep water; jobs not allowed: public transport (bus driver), police, military, aviation
  • Avoid scuba diving, hanggliding, parachuting, rock climbing, car racing and swimming alone especially surfing; contact sports: relative CI
  • can expect to have normal sexual life and normal children and your children have a slightly increased chance of having epilepsy (3%).
  • Red flags: Take special care with open fires, do not swim unsupervised
  • Advice for carers:
    o Do’s: roll person on to his side with head turned to one side and chin up and call for medical help if convulsion lasts longer than 10 minutes
    o Don’ts: move person unless necessary for safety, force anything into person’s mouth, try to stop the fit
  • Regular follow-ups: monitor medication levels and side effects of the drugs
  • Refer to support groups
  • Reading materials
  • In female patients: interaction with OCP so increased doses; if patient wants to get pregnant (high-risk pregnancy) à start patient on 5mg folic acid; planned pregnancy; NO contraindication for breastfeeding
20
Q

COMATOSE - PE

A

Examination
- Inspection for any bruises, lumps/bumps, bleeding, signs of trauma (raccoon eyes, battle sign, bleeding from ears, nose), jaundice, facial asymmetry, check PEARL (miosis: pontine lesions, opioid overdose; dilated: raised ICP; signs of multiorgan failure, funduscopy for raised ICP and diabetic/HTN changes), neck stiffness, mouth for tongue bite marks

  • Face: breathing pattern (metabolic acidosis à DKA, hypoventilation, drug overdose), smell of the breath (DKA – fruity smell, alcohol, fetor hepaticus and uremic coma)
  • Peripheries: Tone, IV drug marks/insulin injection marks, snake bite, circulation, pulse oximetry, temperature, hydration
  • Heart: arrhythmia
  • Urine dipstick and BSL
21
Q

COMATOSE - INVESTIGATIONS

A

Investigations
Blood:
FBE, blood cultures, ESR/CRP, LFTs, blood or urine drug screen, Urea & Electrolytes, RFTs, TFT

Urine:
Drug screen

Imaging:
cranial CT scan,
lumbar puncture