CNS Drugs (Psychotherapeutic, anti-Parkinson's) Flashcards

1
Q

Parkinson’s symptoms are caused by an imbalance of ______ and _______ because ______-producing neurons are lost.

(fill in the three blanks with either dopamine or acetylcholine)

A

Parkinson’s symptoms are caused by an imbalance of dopamine and acetylcholine because dopamine-producing neurons are lost.

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2
Q

Direct and Indirect DA System drugs
name one direct and two indirect
also name one anticholinergic for fun

A

direct: DA receptor agonists
indirect: levodopa-carbidopa, selegiline (MAOI)
anticholinergic: benztropine

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3
Q
Indirect: Levodopa-carbidopa 
what is levodopa? 
how long until levodopa therapy fails? 
AEs
Care
A

a precursor to dopamine (it can cross the BBB, but dopamine cannot). it’s very similar to a cyclic amino acid.

fails between 5 and 10 years after starting

AEs: nausea, vomiting, dyskinesia (large flinging movements of arms/legs, chewing motions), psychosis

Care: hypotension, dizziness, must avoid high protein foods/diet (because amino acids competitively reduce GI absorption and transport across BBB), dark urine and sweat (harmless).
- taking levodopa with non-selective MAOIs (antidepressants) can cause hypertensive crisis

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4
Q

Combination therapy
why give levodopa with carbidopa?
what do COMT inhibitors do? name one

A

carbidopa stops conversion of levodopa from happening in the PNS, because we want it to be converted in the brain (CNS)

COMT inhibitors stop the breakdown of levodopa to an inactive substance.
entacapone is an example

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5
Q

Indirect: Selegiline
it’s a MAOI - what does this mean?
Mechanism

A

It is a selective monoamine oxidase-B inhibitor. MAO-B breaks down dopamine in the presynaptic terminal, and selegiline stops this

Mechanism: irreversibly binds and inhibits MAO-B (but you don’t get the “cheese” effect because it’s selective for just B and doesn’t affect MAO-A)

it’s used as an adjunctive agent alongside levodopa

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6
Q

Direct: DA Receptor Agonists

A

1st line treatment for PD, but we didn’t discuss them because they have lots of adverse side effects like hallucinations and impulse-control disorders

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7
Q

Anticholinergic agents - background
are cholinergic pathways excitatory or inhibitory?
what do we see as a result of unrestrained cholinergic activity?

A

cholinergic pathways are excitatory

we see muscle tremors, cogwheel rigidity, pin-rolling and head-bobbing

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8
Q
Anticholinergic agents
name one
Indications
AEs (4)
Care
A

benztropine

Indications: muscle tremors associated with PD (but do NOT relieve bradykinesia), and drug-induced extrapyramidal symptoms

AEs: typical anticholinergic effects (dry mouth, constipation, urinary retention blurred vision)

Care: assess for signs of PD - masklike expression, dysphagia. assess for signs of it working like less tremor and more relaxed muscles

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9
Q

Psychotherapeutics

A

Treatment of emotional and mental disorders (anxiety, mood disorders, and psychoses)

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10
Q

Antidepressants

Newer-generation
name two classes

Older-generation
name two classes

A

newer: SSRIs and SNRIs
older: TCAs and MAOIs

make sure you know what the abbreviations mean

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11
Q
SSRIs
name one
time to take effect
mechanism
benefits compared to older gen
Indications
AEs 
Serotonin syndrome (when, signs?)
A

sertraline (Zoloft)
may take 2-6 weeks to take effect

mechanism: blocks reuptake of 5-HT (serotonin) into the presynaptic terminal
benefits: no effect on CV system and fewer drug/food interactions

Indications: major depressive disorder, bipolar affective disorder, eating disorders, OCD

AEs: sexual dysfunction, weight gain

SS: within 2-72 hours, confusion, tachycardia, hypertension, tremor

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12
Q

SNRIs
name one
therapeutic/adverse effects

A

venlafaxine

effects same as SSRIs

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13
Q
TCAs
name one
Indications
mechanism
AEs
A

Amitriptyline (largely replaced by SSRIs and SNRIs)

Indications: depression, childhood enuresis (use imipramine)

mech: blocks both NE and 5-HT reuptake (yay) but also alpha-adrenoreceptors (oh no)

AEs: sedation, anticholinergic effects, orthostatic hypotension (from a1 blockage)
SERIOUS: cardiac dysrhythmia, seizures
overdose can be lethal, with no antidote except activated charcoal

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14
Q

MAOIs
mechanism
AEs
Care

A

mechanism: inhibit MAO enzyme in CNS

AEs: orthostatic hypotension, hypertensive crisis (the cheese effect) due to ingestion of tyramine - you get severe headache, hypertension, tachycardia
- because tyramine causes release of NE leading to increase in BP

Care: may take 2 to 4 weeks to see effects

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15
Q

Foods that contain tyramine

A

aged/mature cheeses, smoked/pickled meats, yyeast extracts, red wines

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16
Q

If switching from ______ to MAOI, you must do a wash-out period where you are taking neither drug. How long is it?

A

SSRIs

2 to 5 weeks

17
Q

Anxiety disorder drugs
name two classes
Indications
mechanism

A

benzodiazepines, SSRIs

mech: depress activity in brainstem and limbic system for immediate relief (short-term)

18
Q

Benzodiazepines
name one
Indications
mechanism

A

Lorazepam (Ativan)

Indications: anxiety

mech: enhance the effects of GABA = decreased neuronal excitability, fewer action potentials

AEs: decreased CNS activity (drowsiness, dizziness, confusion, loss of coordination)

19
Q

Mania and Bipolar disorder drugs
mood stabilizer - name one
other drugs - name one

A

Lithium
narrow therapeutic range of 0.4 and 1.5 mmol/L (most treated at 0.6-0.8 range)

AEs: lithium toxicity when above 1.5 mmol/L - CNS effects of confusion, hyperirritability of muscles

other drug: valproate

20
Q

Psychotic disorders (schizophrenia)
another name for antipsychotics?
first and second gen - name one of each

A

another name: neuroleptics

first (typical): chlorpromazine
second (atypical): clozapine

21
Q

Typical antipsychotics

mechanism

A

chlorpromazine

mech: Dopamine D2 receptor antagonists (but also histamine, muscarinic, and a1-adrenoreceptors)

AEs: extrapyramidal motor disturbances (dystonia, pseudo-parkinsonism, and akathisia)
- can be reduced with anticholinergic (benztropine)
- worst is tardive dyskinesia which is irreversible (tongue protrusion, lip smacking)
DANGEROUS: fever up to 41 C, CV problems
administer a dopamine receptor agonist to combat the syndrome (bromocriptine)

22
Q

Atypical antipsychotics
mechanism
benefits
Care

A

clozapine

mech: block 5-HT receptors, less effect on DA receptors and therefore less motor disturbances
ben: very little EPD

AEs: sedation, constipation, hypotension (same as typical)

  • agranulocytosis (WBCs) and anemia - must take regular blood counts
  • also weight gain, blood glucose disturbances (metabolism)

Care: do NOT take with alcohol