CNS Flashcards
intracranial HTN cut off
- 40 is severe(ischemia)
signs of elevated ICP
HA/nausea then decreasing consciousness then coma/cushing response and motor posturing
normal ICP
5-10
cerebral auto regulation range
50-150
cerebral steal
vasodilation that occurs in healthy region of brain during period of ischemia. so pulls blood flow from ischemia to healthy brain. so ischemia gets even worse blood flow.
inverse cerebral steal/robin hood
vasoconstriction caused by hyperventilation or drug that causes vasoconstriction in healthy area to have more flow go to ischemia area
how much oxygen and glucose does brain get over needed
3x oxygen and 7x glucose during normal activity
CBF numbers
50mL/100g/min. gray matter is 80, white is 20
CBF per min
750mL/min
CBF ischemia numbers by 100g
20-30 start of neuro symptoms. 15-20 isoelectric EEG, no evoked potentials. 10-15 Na/K pump fail, cytotoxic edema. less than 10 is irreversible damage
CSF volume
124-150mL
CSF production per hour
20-30cc
what makes CSF
choroid plexus ependymal cells
pH of CSF
7.32
IV anesthetics that stand out brain
ketamine up CBF. etomidate can precipitate seizure