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Pharmacology > CNS #2: Anticonvulsants & Aesthetics > Flashcards

CNS #2: Anticonvulsants & Aesthetics Flashcards

1
Q

Define simple partial seizure

A

No loss of consciousness

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2
Q

Define complex partial seizure

A

Consciousness is altered

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3
Q

*What is the MOA of anticonvulsants?

A
  • Inhibit excitatory activity (inhibit glutamate release; block Na and Ca channels)
  • Enhance GABA inhibitory actions
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4
Q

What is the MOA of Benzodiazepines

A

Bind to GABA receptors (inhibitory) to decrease neuronal diring

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5
Q

What is the use of BZDs

A

Anticonvulsant

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6
Q

What is the MOA of Carbamazepine (Tegretol)?

A

Inhibit Sodium channels; omduces CYP 450

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7
Q

What is the use of Carbamazepine

A

Anticonvulsant

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8
Q

What are AE of Carbamazepine?

A

Blood cell abnormalities and dermatologic reactions

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9
Q

What is an AE of Valproic Acid-Divalproex (Depakote)

A

Hepatic failure and pancreatitis

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10
Q

What is the use of valproic acid -divalproex (depakote)

A

generalized seizure

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11
Q

What is the MOA of Ethosuzimide (Zarontin)

A

Inhibit T-type Ca channels

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12
Q

What is the use of Ethosuximide (Zarontin)

A

Absence seizures

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13
Q

What is the MOA of Febalmate (Felbatol)?

A

Block Ca and Na channels, GABA potentiation, NMDA antagonist

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14
Q

What is the use of Felbamate (Felbatol)?

A

Refractory partial seizure disorder

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15
Q

What is the use of Gabapentin(Neurontin)?

A

Antivconvulsant (partial seizures & generalized tonic clonic) Neuropathic pain

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16
Q

What is the MOA of Ethosuximide?

A

Blocks Ca channels

17
Q

What is the MOA of Oxcarbazepine

A

Blocks Na channels

18
Q

What is the MOA of Phenytoin?

A

Blocks Na channels

19
Q

What is the MOA of Tigabine?

A

Gaba receptor

20
Q

What is the MOA of Vigabatrin?

A

Irreversible binding of GABA-T

21
Q

What is the MOA of Lamotrigine (Lamictal)?

A

Blocks Na & Ca channels

22
Q

What is Lamotrigine (Lamictal) used for?

A

Anticonvulsant (Partial Seizures)

23
Q

What is an AE of Lamotrigine (Lamictal)

A

Severe rash

Pharmacology (5 decks)

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