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Pre-reg > CNS > Flashcards

CNS Flashcards

1
Q

What is the first line treatment for ADHD in adults and children

A

Methylphenidate

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2
Q

What is second line treatment and an alternative for ADHD in adults and children

A

Lisdexamfetamine (dexamphetamine for pts intolerant)
Atomoxetine

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3
Q

Should methylphenidate be prescribed by brand

A

YES

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4
Q

What are common side effects of methylphenidate

A

Appetite loss
Insomnia
Weight loss
Increased HR and BP
Tics and tourettes
Growth restriction in children

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5
Q

What are contraindications with methylphenidate

A

CVD
Hyperthyroidism
Severe HTN
Uncontrolled bipolar
Severe depression

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6
Q

What monitoring is required with methylphenidate

A

Pulse
BP
Weight
Height
Psychiatric symptoms

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7
Q

What are side effects of dexamfetamine and lisdexamfetamine

A

Appetite loss
Anorexia
Increased HR and BP
Tics and tourettes
Growth restriction in children

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8
Q

What monitoring is required with dexamfetamine and lisdexamfetamine

A

Pulse
BP
Weight
Height
Psychiatric symptoms

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9
Q

What are contraindications with dexamfetamine and lisdexamfetamine

A

CVD
Hyperthyroidism
Moderate/Severe HTN
Agitated states

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10
Q

What are signs of overdose with dexamfetamine and lisdexamfetamine

A

Wakefulness
Hyperactivity
Paranoia
Hallucinations
HTN

*Followed by exhaustion

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11
Q

What are side effects of Atomoxetine

A

Suicidal ideation
Hepatotoxicty
QT prolongation

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12
Q

What monitoring is required with Atomoxetine

A

Pulse
BP
Psychiatric symptoms
Appetite
Weight
Height

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13
Q

What class of drugs is first like for mild-moderate Alzheimer’s disease

A

Acetylcholinesterase inhibitors

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14
Q

Give examples of acetylcholinesterase inhibitors

A

Donepezil
Galantamine
Rivastigmine

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15
Q

Which Ach inhibitors has an increased risk of Neuroleptic Malignant Syndrome

A

Donepezil
*Risk increased with concomitant antipsychotics

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16
Q

Which Ach inhibitor has a risk of SJS occuring

A

Galantamine

17
Q

Which Ach inhibitor is used in Parkinsons disease

A

Rivastigmine

18
Q

Which Ach inhibitor has an increased risk of GI disturbances

A

Rivastigmine
*Use transdermal patches

19
Q

What is licensed for moderate-severe Alzheimer’s

A

Memantine
*Ach inhibitors are contra-indicated in moderate / severe

20
Q

What are cholinergic side effects

A

Diarrhoea
Urination
Muscle weakness, Cramps
Bronchospasm
Bradycardia
Emesis (vomiting)
Lacrimation (teary eyes)
Salivation / sweating

21
Q
A

Pre-reg (20 decks)

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