CNS Flashcards

1
Q

What makes up the hindbrain?

A

-medulla
-pons
-cerebellum

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2
Q

What makes up the midbrain?

A

-substantia nigra (SN)

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3
Q

What makes up the forebrain?

A

-cerebral cortex
-basal ganglia: striatum (caudate & putamen), globus pallidus, sub-thalamic nucleus
-limbic system: hippocampus, anygdala
-dienecephalon: thalamus, hypothalamus

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4
Q

What are the parts of substantia nigra?

A

-SN pars compacta
-SN pars reticulata

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5
Q

What role does the SN pars compacta play?

A

-provides input to the basal ganglia, supplies dopamine to the striatum
*undergoes neurodegeneration in PD

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6
Q

What role does the SN pars reticulata play?

A

-has an output function, relays signals from the basal ganglia to the thalamus

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7
Q

What does the cerebellum do?

A

-hindbrain
-“little brain”
-governs motor coordination for producing smooth movements
*undergoes neurodegeneration in spinocerebellar ataxias

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8
Q

What does the medulla do?

A

-hindbrain
-“autonomic functions”
-includes centers for controlling respiration, cardiac function, vasomotor responses, reflexes (coughing)

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9
Q

What does the pons do?

A

-hindbrain
-“bridge”
-relays signals from the forebrain to the cerebellum

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10
Q

What does the cortex (cerebrum) do?

A

-forebrain
-processing and interpreting information
-“high-order processes”
-Schizophrenia is considered a disease of the frontal cortex

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11
Q

What does the limbic system do?

A

-forebrain
-emotions (amygdala)
-memory (hippocampus)

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12
Q

What does the hypothalamus do?

A

-regulates internal homeostasis, emotions
-hormonal control (through the pituitary gland) and direct neural regulation
-involuntary functions

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13
Q

What does the thalamus do?

A

-‘relay station’ to and from the cortex

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14
Q

What does the basal ganglia do?

A

-voluntary motor control, some cognitive functions

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15
Q

What do astrocytes do?

A

-provides neurons with growth factors, antioxidants
-supports blood-brain barrier
-removes excess glutamate

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16
Q

What do oligodendrocytes do?

A

-produces myelin sheath

17
Q

What do microglia do?

A

-provides growth factors
-clears debris via phagocytosis
-plays a role in neuroinflammation (if overactive)

18
Q

What is an EPSP?

A

EPSP- excitatory postsynaptic potential–> subthreshold depolarization peak

19
Q

What are the various mechanisms that alter synaptic transmission?

A

Metabolism- can inhibit enzymes that breakdown neurotransmitters
Uptake- transporters can be blocked to prevent uptake into either the neuron or glial cell
Receptor- can have agonist or antagonist effects that targets the natural neurotransmitter
Degradation- enzymes can inhibit/promote degradation

20
Q

What are the common amino acid neurotransmitters?

A

Glutamate
Glycine
GABA

21
Q

What can excess glutamate do to a neuron?

A

-cause neuronal damage by allowing excessive Ca2 influx into the neuron

22
Q

What is glycine similar to?

A

-GABA but works in the spinal cord

23
Q

What does GABA do?

A

-major inhibitory neurotransmitter in the brain
GABA A ion channel allows for influx of Cl- ion

24
Q

What does Glutamate do?

A

-offsets GABA
-major excitatory neurotransmitter in the brain
-can be metabotropic (GPCRs) or ionotropic (AMPAs or NMDAs)

25
Q

What are the common non-amino acid neurotransmitters?

A

Serotonin
Dopamine
Acetylcholine
Norepinephrine

26
Q

What type of drugs target Acetylcholine?

A

-cholinesterase inhibitors such as Aricept used to treat Alzheimer’s disease

27
Q

What type of drugs target Dopamine?

A

-drugs that block DAT increasing intracellular dopamine (amphetamine and cocaine)
-antipsychotics (D2 receptor antagonists)
-D2/D3 & D1 receptor agonists for Parkinson’s Disease
-excess dopaminergic signaling may be involved in Schizophrenia

28
Q

What type of drugs target Norepinephrine?

A

-NET inhibitors are used to treat depression

29
Q

What type of drugs target Serotonin?

A

5-HT2A Antagonists as atypical antipsychotics; can be useful for schizophrenia treatment
5-HT1D agonists for migraine
5-HT2A agonists are hallucinogenic (LSD)
SERT uptake inhibitors for depression
*5-HT axons arise from cell bodies call raphe nuclei

30
Q
A