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Neurology 3rd year > CN palsies > Flashcards

CN palsies Flashcards

1
Q

What is the function of CN 2?

A

Optic Nerve:
- transmits all visual information including brightness perception, color perception and contrast (visual acuity)
- accommodation reflex: swelling of the lens of eye that occurs when one looks at a near object as in reading
- Pupillary light reflex (afferent arm) : A greater intensity of light causes the pupil to constrict (miosis), whereas a lower intensity of light causes the pupil to dilate (mydriasis)
(the iris is the actual muscle the responds to light)

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2
Q

What is the blind spot?

A
  • obscuration of the visual field
  • place in the visual field that corresponds to the lack of light-detecting photoreceptor cells on the optic disc of the retina where the optic nerve passes through the optic disc
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3
Q

What is scotoma and causes?

A
  • alteration in the field of vision: partially diminished or entirely degenerated visual acuity that is surrounded by a field of normal – or relatively well-preserved – vision.
  • causes: demyelinating eg MS (retrobulbar neuritis), damage to nerve fiber layer in the retina (seen as cotton wool spots) due to hypertension, vascular blockages either in the retina or in the optic nerve, stroke or other brain injury, macular degeneration pituitary tumours, severe pre-eclampsia. Scintillating scotoma is a common visual aura in migraine.
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4
Q

CN 2 lesions - DDx

A

Optic neuritis
anterior fossa tumours
Optic chiasm - pituitary tumours

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5
Q

Summarise the visual pathway

A

Ganglion cells (in the retina) → optic nerve → optic canal (sphenoid bone) → left and right side of the optic chiasm (middle cranial fossa) → optic tracts → lateral geniculate nuclei (thalamus) → superior colliculus → lingual and cuneus gyrus (visual cortex - occipital lobe)

Fibers from nasal retina: cross at the optic chiasm
Fibers from temporal retina: continue ipsilaterally at the optic chiasm

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6
Q

Visual pathway lesions

A
  • ipsilateral monocular blindness (optic nerve lesion)
  • bitemporal hemianopia (lesion at optic chiasm) - tunnel vision
  • homonymous hemianopia (lesion at optic tract)
  • homonymous quadrantanopia (temporal or parietal lesion)
  • homonymous hemianopia with macular sparing (lesion at optic cortex)
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7
Q

CN 3 - function

A
  • Eye movement: superior rectus, inferior rectus, medial rectus, and inferior oblique muscles
  • Eyelid opening: levator palpebrae superioris
  • Pupillary constriction (parasym): sphincter pupillae (Edinger-Westphal nucleus and muscarinic receptors)
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8
Q

CN 3 palsy

A
  • DDx = aneurysm of posterior communicating artery, nerve infarction (eg diabetes), midbrain infarction or tumour
  • signs = unilateral complete ptosis (drooping eyelid), eye deviated down and out, and fixed and dilated pupil
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9
Q

CN 5 - function

A
  • sensory to face: 3 branches = ophthalmic, maxillary, mandibular
  • motor component to muscles of mastication
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10
Q

CN 5 palsy

A
  • DDx = brainstem pathology (infarction, demyelination, tumour), CP angle tumours (acoustic neuroma), infection
  • signs = unilateral sensory loss on face, scalp, anterior 2/3 of tongue and buccal mucosa
    trigeminal neuralgia not necessarily a CN 5 palsy (?)
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11
Q

CN 6 palsy

A

Abducens (lateral rectus)

  • DDx = MS, wernicke’s encephalopathy, pontine stroke, infections
  • signs = horizontal diplopia when looking into the distance, maximal when looking at the side of the lesion, eye cannot be fully abducted and can get estropia (inwards eye deviation)
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12
Q

Diplopia - definition and causes

A
  • Double vision: simultaneous perception of two images of a single object that may be displaced horizontally, vertically, diagonally or rotationally. Usually the result of impaired function of the extraocular muscles (EOMs)
  • causes: EOMs may have mechanical problems, disorders of the neuromuscular junction, disorders of the cranial nerves (III, IV, and VI) and occasionally disorders of the supranuclear oculomotor pathways
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13
Q

CN 7 - function

A
  • motor (somatic): muscles of facial expression
  • motor (parasym): control of salivary glands (submandibular and sublingual) and lacrimal glands
  • sensory: taste fibres to anterior 2/3 of tongue
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14
Q

CN 7 palsy

A
  • UMN lesion: contralateral weakness of lower part of face (forehead spared) eg STROKE
  • LMN lesion: ipsilateral weakness of all facial muscles (forehead included). Angle of mouth falls and taste is frequently impaired eg BELL’S PALSY
  • DDx: Bell’s palsy vs Stroke, Ramsay hunt syndrome (herpes zoster infection of geniculate ganglion), trauma, tumour eg facial neuromas
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15
Q

Bell’s palsy - definition

A

Acute unilateral peripheral facial nerve palsy in patients for whom physical examination and history are otherwise unremarkable, consisting of deficits affecting all facial zones equally that fully evolve within 72 hours

  • reactivation of herpes simplex virus type 1 (HSV-1) within the geniculate ganglion results in destruction of ganglion cells and infection of Schwann cells, leading to demyelination and neural inflammation

(ramsay hunt is reactivation of vzv - and presents with facial nerve palsy, auricular pain, vesicular rash around the ear)

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16
Q

Bell’s palsy - clinical features

A

single episode (recurrence very rare)
unilateral
absence of constitutional symptoms eg fever, myalgia
involvement of all nerve branches (LMN lesion)
keratoconjunctivitis sicca (dry eye - parasym dysfunction to lacrimal gland)
pain = post-auricular pain and mild/moderate otalgia
synkinesis = involuntary synchronous movement of a facial region concomitant with reflex or voluntary movement in another facial region (chronic stage only)

17
Q

Bell’s palsy - investigations

A
  • Clinical Dx
  • rule out stroke, pts often concerned
  • can do EMG which shows decreased amplitude of muscle action potential on affected side
18
Q

Bell’s palsy - management

A
  • oral prednisolone
  • eye protection for dry eye: wear glasses and give artificial tears + ophthalmic lubricant at night
  • severe: aciclovir and/or surgical decompression
19
Q

CN 8 palsy

A
  • cochlear lesion: deafness and tinnitus

- vestibular lesion: vertigo, N+V. Causes: BPPV, meniere’s, alcohol, AEDs, migraine, MS, mumps, some Abx (gentamicin)

20
Q

Conductive vs Sensorineural hearing loss

A
  • conductive = blockage in the outer or middle ear preventing conduction of sound into the inner ear
    DDx - foreign bodies, otitis externa, excess wax, perforated tympanic membrane
  • Sensorineural = resides in the sensory (hair cells) or neural portion i.e the inner ear.
    DDx - ageing, genetics eg otosclerosis, loud noises, trauma, tumours, meniere’s
21
Q

CN 9 - function

A
  • sensory: taste to posterior 1/3 of tongue, afferent arm of gag reflex, carotid sinus (baroreceptors for BP) and carotid body (chemoreceptors - partial pressure of O2 and CO2, and pH)
  • motor (somatic): pharyngeal muscles (swallowing)
  • motor (parasym): parotid glands (salivation)
22
Q

CN 9 palsy

A
  • unilateral lesion causes diminished sensation on same side of pharynx.
  • together with CN X lesion causes absent gag reflex, palatal weakness, reduced sensation and choking
  • can result in loss of taste sensation to the posterior one third of the tongue, and impaired swallowing
  • usually brainstem lesion eg stroke
23
Q

What is pseudobulbar palsy?

A
  • Bilateral lesions of the corticobulbar tracts. Symptoms include slow, dysarthric speech and variable dysphagia, spasticity of the tongue and musculature of the pharynx and larynx, while pharyngeal and palatal reflexes remain intact
  • can be caused by trauma, neurological disease (Parkinson’s, multiple sclerosis, etc), metabolic, vascular, tumor, nerve palsies (trigeminal, facial, vagus, hypoglossal and spinal accessory nerves)
24
Q

CN 11 palsy

A
  • results in weakness of sternocleidomastoid (rotation of head to opposite side) and trapezius (shoulder shrugging)
  • injury can occur during neck surgery, trauma or spontaneously
25
Q

CN 12 function and palsy

A
  • function (motor): tongue protrusion = intrinsic and extrinsic muscles of the tongue
  • LMN lesion = unilateral tongue weakness, wasting and fasciculation
  • bilateral supranuclear (UMN) lesion (rare) = slow, limited tongue movements and stiff tongue that cannot be protruded far, with absent fasciculation
  • causes: compression by tumours and gunshot wounds, surgical damage, medullary stroke, MS, GBS, infection, sarcoidosis
26
Q

intorsion vs extorsion

A 
Intorsion = down and in (superior oblique - CN4)
Extorsion = external rotation (inferior oblique)

therefore CN 4 palsy will make eye deviate up and in
pt typically tilts head to opposite side to compensate for double vision

27
Q

Relative Afferent Pupillary Defect

A

If an optic nerve lesion is present the affected pupil will not constrict to light when light is shone in the that pupil during the swinging flashlight test. However, it will constrict if light is shone in the other eye (consensual response).

Some causes of a RAPD include:

  • optic neuritis
  • ischemic optic disease or retinal disease
  • severe glaucoma causing trauma to optic nerve
  • direct optic nerve damage (trauma, radiation, tumor)
  • retinal detachment
  • very severe macular degeneration
  • retinal infection (CMV, herpes)
28
Q

Argyll Robertson Pupil

A

This lesion is a hallmark of tertiary neurosyphillis

Pupils will NOT constrict to light but they WILL constrict with accommodation

Pupils are small at baseline and usually both involved (although degree may be asymmetrical)

29
Q

Horner’s - triad and causes

A

triad: ptosis, miosis, anhydrosis

Causes

  • carotid artery dissection
  • pancoast tumors, nasopharyngial tumors
  • lymphoproliferative disorders
  • brachial plexus injury
  • cavernous sinus thrombosis
  • cluster headache
  • stroke
  • thyroidectomy
30
Q

CN2 vs CN3 damage

A

direct pupillary constriction is lost in the affected eye in both cases
however
in CN2 lesion –> no consensual response either (both eyes affected)
in C3 lesion –> consensual response present (ipsilateral eye constricts)

Neurology 3rd year (13 decks)

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