CMML Flashcards

1
Q

Are immunophenotypic abnormalities seen in reactive monocytosis?

A
  • yes, but usually limited to one or at most two abnormalities.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are some immunophenotypic abnormalities described in CMML?

A
  • Decreased expression of monocytic markers (HLA-DR, CD13, CD15, and CD36)
  • Over-expression of CD56
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is important to remember about CD56 expression on monocytes?

A
  • As the sole abnormality does NOT imply neoplasm
  • CD56 can be seen on monocytes in reactive conditions and during marrow regeneration after chemotherapy.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What key marker seemed to differentiate CMML monocytes from reactive ones?

A
  • CD14
  • patients with CMML more likely to have a subset of monocytes expressing decreased or moderate levels of CD14.
  • This finding in the presence of 20% or more monocytes in the marrow with one more immunophenotypic abnormality found to be sensitive for CMML vs. reactive monocytosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What does the decrease in CD14 expression on the monocytes likely represent?

A
  • likely represents at least some left shift with presence of monoblasts and promonocytes
  • IMP: the CD14 clone is important to know because some only mark mature monocytes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What other cell population has been noted to be increased in CMML?

A
  • plasmacytoid dendritic cells
  • Found in the blast gate
  • Show expression of bright CD123 and HLA-DR
How well did you know this?
1
Not at all
2
3
4
5
Perfectly