clozapine Flashcards
average dose
450
dose you get a response from
150-900
threshold LEVEL for response
350-420
over what level is there a risk of seizures
500
who may need lower dose of clozapine
females, NON smokers, those on SSRIs, elderly
If level is what then add anticonvulsant
> 500 consider
1000 defs and try to reduce level (unless well tolerated)
Longer half life clozapine or norclozapine
norclozapine
average norclozapine ratio
1.3
what ratio suggests compliance
0.5-2.5
What may cause ratio more than 2.5
saturated metabolism
taken clozapine recently
what may cause low ratio
missed dose, fast metabolism or took clozapine longer ago
what level of WCs indicates neutropenia
under 1.5
what level of cells indicates agranulocytosis
under 0.5
what percent of pts get neutropenia on clozapine
2.7
what percent of pts get agranulocytosis on clozapine
0.8
