clotting - tests and disorders

Question 1

what are some causes of neutropenia

Answer 1

myeloma, feltys disease, SLE, haem malignancy, chemo, EBV

Question 2

what do blood show in DIC

Answer 2

-prolonged APTT
-prolonged PT
-low fibrinogen
-raised fibrin degradation products
-thrombocytopenia
-blood film - schistocytes (MAHA)

Question 3

target INR in afib

Answer 3

2.5

Question 4

target INR in RECURRENT DVT

Answer 4

3.5

Question 5

when does warfarin need to be stopped before surgery

Answer 5

5 days

Question 6

where should INR results be recorded and what should you be aware of

Answer 6

the yellow book, need to be aware of the reasons for anticoagulation, target INR and duration of treatment

Question 7

how do you reverse warfarin when someone has major bleeding

Answer 7

IV vit K1 and prothrombin

Question 8

contraindications to warfarin

Answer 8

clinically significant bleeding, severe hepatic impairment and pregnancy

Question 9

advice for patients on warfarin

Answer 9

take yellow book with them where ever they go, take warfarin at the same time each day, limit alcohol and be careful when brushing teeth

Question 10

what tests do you do for haemachromatosis

Answer 10

Transferrin and ferritin (transferrin saturation should be kept below 50% and the serum ferritin concentration below 50 ug/l)