Clotting Factors

Question 1

CF II

Answer 1

Prothrombin

Question 2

CF V

Answer 2

Preacceleran

Question 3

CF VII

Answer 3

Proconvertin

Question 4

CF VIII

Answer 4

Antihemophilic factor

Question 5

CF IX

Answer 5

Christmas factor

Question 6

CF X

Answer 6

Stuart-prower factor

Question 7

CF XI

Answer 7

Plasma thromboplastin antecedent

Question 8

CF XII

Answer 8

Hageman factor

Question 9

CF XIII

Answer 9

Fibrin stabilizing factor

Question 10

extrinsic pathway

Answer 10

• *Tissue factor causes the release of
• ->proconvertin CF 7 which stimulates
• ->Stewart prowler factor CF 10

Question 11

Intrinsic pathway

Answer 11

Collagen fibers expos causes the release of

• ->Heggemann factor CF 12 which then releases
• ->plasma thromboplastin antecedent CF 11 which then causes the release of
• ->Christmas factor CF nine which stimulates the release of
• ->Stuart Prower factor

Question 12

Cf I

Answer 12

Fibrinogen

Question 13

Clotting Cascade

Answer 13

CF 10  Prothromin (CF 2)  thrombin  fibrinogen (CF 1)  fibrin

Question 14

Fibrin

Answer 14

forms a net and traps the formed elements in blood  COAGULATION
(blood clot)

Question 15

Ca2+

Answer 15

necessary component of coagulation

Question 16

Platelet Activation and the Platelet Plug

Answer 16

-ONLY occurs inside injured blood vessels

Question 17

Platelet Activation

Answer 17

1. exposure of collagen fibers of subendothelial cells of blood vessels to
   blood flow 2. von Willebrand factor (circulating in blood in inactive form) becomes
   activated and attaches to the exposed collagen fibers, stopping
   movement of platelets  platelets form a single layer on top of the
   exposed collagen 3. Platelets become activated and then attach a second layer of platelets,
   etc.

Question 18

Activated platelets release

Answer 18

o ADP – promotes platelet activation o Thromboxane A2 (TxA2) – vasoconstriction o Growth factors – promote wound healing, fibroblast chemotaxis

Question 19

Anticoagulation System

Answer 19

3 components:

• -hemodynamics
• -endothelial mediation
• -fibrinolitic system

Question 20

Hemodynamics

Answer 20

– slow blood flow is important for coagulation otherwise

activated CFs get washed out and a clot cannot be formed

Question 21

Endothelial mediationtion

Answer 21

– platelet plug is formed, surrounding uninjured
endothelial cells release prostacyclin (PGI2) which prevents extra or
excess platelet aggrega

Question 22

Fibrinolitic system

Answer 22

– CF 12 also activates tissue plasminogen activator,
which converts plasminogen into plasmin, resulting in degradation of
activated CFs