clotting factors

Question 1

factor I

Answer 1

fibrinogen-
liver- no K- forms clot
Ia fibrin

Question 2

factor II

Answer 2

prothrombin-
liver- yes K- when active, it activates 1,5,8, platelets and protein C

IIa- thrombin

Question 3

factor III

Answer 3

tissue factor (thromboplastin)-
 vascular well- cofactor of VII- activates platelets, activates clotting cascade

Question 4

factor IV

Answer 4

calcium-

diet-promotes clotting reactions

Question 5

factor V

Answer 5

proaccelerin-

liver- no K- cofactor of X, forms a prothrombinase complex ( where intrinsic and extrinsic paths meet)

Question 6

factor VII

Answer 6

proconvertin-

liver- yes vit K- activates IX and X

Question 7

factor VIII

Answer 7

antihemophiliac-

liver- no vit K- cofactor of iX

Question 8

vWF

Answer 8

von willebrand-

endothelial cells-modulates adhesion

Question 9

factor IX

Answer 9

Christmas-

liver-yes vit K- activates X

Question 10

factor X

Answer 10

Stuart- Prower-

liver- yes vit K- activates II, forms a prothrombinase complex with V (where intrinsic and extrinsic paths meet)

Question 11

factor XI

Answer 11

Plasma thromboplastin antecedent-

liver-no vit K- activates IX

Question 12

factor XII

Answer 12

Hageman-

liver- no vit K- activates XI

Question 13

factor XIII

Answer 13

fibrin stabilizing- liver- no vit K- crosslinks fibrin

Question 14

the pneumonic …

Answer 14

“for platelets to clot, plasma proteins aggragate very carefully so people have fibrin”

Question 15

what factors do not synthesize in liver?

Answer 15

III (tissue factor), IV( calcium), VWF ( von willebrand)

Question 16

what factors are part of extrinsic pathway?

Answer 16

III, VII “buy extrinsic for 37 cents”

Question 17

what are part of extrinsic pathway?

Answer 17

XII, XI, IX, VIII “ $12, $11.98”

Question 18

what factors are common pathway?

Answer 18

X(V), II, I, XIII, stable clot 105-21-13

Question 19

what do endothelial cells synthesize and secrete?

Answer 19

procoagulants, anticoagulants, fibrinolytics- VWF, tissue factor, NO, prostacyclin, A2, ADP

Question 20

what cause vasoconstriction?

Answer 20

A2, ADP

Question 21

what causes vasodilation?

Answer 21

NO, prostacyclin- vasodilation allows coag factors to circulate to vessel injury and start clotting process. from adventita layer, vasodilation can also inhibits platelet adhesion, washes away procoagulation mediators

Question 22

what factors are in intima?

what factors in media?

Answer 22

intima- VWF, tissue factor, prostacyclin, NO

media- collagen, fibronectin

Question 23

What factors are dependent on vit k?

Answer 23

2,7,9,10

Question 24

What factors are source other than liver?

Answer 24

4,8, VWF

Question 25

Thrombin activates what factors

Answer 25

5, 8, 1, 13

Recruits platelets to injured area

Question 26

Activated thrombin must be present to activate sufficient fibrin to form a ______ or _______

Answer 26

Stable or secondary clot