clotting factors Flashcards
factor I
fibrinogen-
liver- no K- forms clot
Ia fibrin
factor II
prothrombin-
liver- yes K- when active, it activates 1,5,8, platelets and protein C
IIa- thrombin
factor III
tissue factor (thromboplastin)- vascular well- cofactor of VII- activates platelets, activates clotting cascade
factor IV
calcium-
diet-promotes clotting reactions
factor V
proaccelerin-
liver- no K- cofactor of X, forms a prothrombinase complex ( where intrinsic and extrinsic paths meet)
factor VII
proconvertin-
liver- yes vit K- activates IX and X
factor VIII
antihemophiliac-
liver- no vit K- cofactor of iX
vWF
von willebrand-
endothelial cells-modulates adhesion
factor IX
Christmas-
liver-yes vit K- activates X
factor X
Stuart- Prower-
liver- yes vit K- activates II, forms a prothrombinase complex with V (where intrinsic and extrinsic paths meet)
factor XI
Plasma thromboplastin antecedent-
liver-no vit K- activates IX
factor XII
Hageman-
liver- no vit K- activates XI
factor XIII
fibrin stabilizing- liver- no vit K- crosslinks fibrin
the pneumonic …
“for platelets to clot, plasma proteins aggragate very carefully so people have fibrin”
what factors do not synthesize in liver?
III (tissue factor), IV( calcium), VWF ( von willebrand)
what factors are part of extrinsic pathway?
III, VII “buy extrinsic for 37 cents”
what are part of extrinsic pathway?
XII, XI, IX, VIII “ $12, $11.98”
what factors are common pathway?
X(V), II, I, XIII, stable clot 105-21-13
what do endothelial cells synthesize and secrete?
procoagulants, anticoagulants, fibrinolytics- VWF, tissue factor, NO, prostacyclin, A2, ADP
what cause vasoconstriction?
A2, ADP
what causes vasodilation?
NO, prostacyclin- vasodilation allows coag factors to circulate to vessel injury and start clotting process. from adventita layer, vasodilation can also inhibits platelet adhesion, washes away procoagulation mediators
what factors are in intima?
what factors in media?
intima- VWF, tissue factor, prostacyclin, NO
media- collagen, fibronectin
What factors are dependent on vit k?
2,7,9,10
What factors are source other than liver?
4,8, VWF
