Clotting disorders Flashcards
Which factor does vWF support?
Factor 8
Which factor is affected in haemophilia A?
Factor 8
Which factor is affected in haemophilia B?
Factor 9
What is Christmas disease?
Haemophilia B (deficiency in factor 9)
What is VWF deficiency disease?
A Type of haemophilia - deficiency in von Willebrand factor limiting platelet aggregation and resulting in a factor 8 deficiency
Which gene is affected in haemophilia A?
F8 on the x chromosome
Which gene is affected in haemophilia B?
F9 on the x chromosome
What is the inheritance pattern for haemophilia A?
X-linked recessive
What is the inheritance pattern for haemophilia B?
X-linked recessive
Which clotting test would be affected in haemophilia A?
APTT (intrinsic pathway) - will be prolonged
Which clotting test would be affected in haemophilia B?
APTT (intrinsic pathway) - will be prolonged
What is the role of desmopressin in Haemophilia A treatment?
Stimulates von Willebrand factor and therefore stabilises factor 8
Which clotting factor is affected by haemophilia C?
Factor 11
Which ethnic group is haemophilia C most prevalent in?
Ashkenazi jews
Where is the gene for haemophilia C located?
Chromosome 4
