Clotting Cascade Physiology Flashcards
How does the extrinsic clotting cascade begin?
When endothelial cells become damaged, they release a tissue factor/thromboplastin (Clotting factor 3a) that activates Clotting Factor 7–> CF 7a.
*** CF 7a will then activate CF 10 to CF10a
CF10a is a part of the common clotting cascade then
What is the route of intrinsic clotting factor activation?
CF 12–> CF12a which then activates CF11 –> CF11A this then converts CF11A to CF 9A (8–> 8a HERE). CF9A then converts
CF10–> CF10A (CF 5–> CF5A HERE)
This will then enter into the common clotting cascade***
What is the common clotting cascade and what is the role of clotting factor 10a here?
10A will convert CF2–> CF2A (Prothrombin–> Thrombin)
CF2A will then convert CF1–> CF1A (Fibrinogen–> Fibrin)
What is Heparin Sulfate?
Heparin Sulfate is a surface protein that activates ANTI-THROMBIN PROTEIN which makes sure that the CF 3 will be inactivated!
What is the role of Aspirin?
Aspirin inhibits cyclic oxygenase which converts Arachidonic Acid–> Thrombaxane A3. Because of this, the stopping of this decreases the clotting cascade and activation of the platelet plug formation.
What is the role of warfarin in clotting cascade prevention?
Warfarin inhibits a key enzyme in the formation of Vitamin K. This enzyme is epoxide hydrolase/reductase enzyme.
Which clotting factors are necessary to form with Vitamin K?
Factors 2, 7, 9, 10 and Protein C and S
Which warfarin isoform is faster in producing a respons? S-warfarin or R-warfarin?
S- warfarin is 2-5x more faster in producing an anticoagulant response
What factor deficiency is associated with Hemophilia A?
Clotting Factor 8
If abnormal PT time, what cascade is effected?
Extrinsic Cascade (3a, 7a, 10)
If abnormal PTT time, which cascade is effected?
Intrinsic Cascade (12, 11, 9+8 , 10+5)
Clotting factors associated with Vitamin K are related to Deep Vein Thrombosis. Which factors are these?
CF 2, CF 7, CF 9, CF 10, Protein C & Protein S
