Clotting cascade

Question 1

how does the clotting cascade begin

Answer 1

damaged blood vessels, walls break open so cells no longer seal the vessel

Question 2

function of platelets

Answer 2

form a plug at damaged vessel and acts as not so strong plug

Question 3

fibrin

Answer 3

form a mesh at the damaged site and hold togetehr the platelet

Question 4

what do fibrin strands form when togetehr

Answer 4

polymer

Question 5

do fibrin molecules float in blood

Answer 5

no

Question 6

does fibrinogen float in blood

Answer 6

yes

Question 7

fibrinogen function

Answer 7

covers active site of fibrin

Question 8

how is fibrinogen converted to fibrin

Answer 8

by thrombin

Question 9

positive feedback system

Answer 9

fibringoen to fibrin

Question 10

negative feedback systems

Answer 10

thrombin helps create plasmin from plasminogen
thrombin produces anti thrombin

Question 11

role of plasmin

Answer 11

acts on fibrin and breaks them

Question 12

role of anti thrombin

Answer 12

stops activated 10 being made form 10

Question 13

role of activated 12 (XII)

Answer 13

Acts as a catalsyst to convert 11 (XI)> activated 11(XIA)

Question 14

role of activated 11

Answer 14

acts as a catlayst to convert inactive 9 (IX) to itds activated form 9a (IXA)

Question 15

what activates 10 (X)

Answer 15

activated 7 (VII)

Question 16

what activates 7

Answer 16

tissue factor 3 (III)

Question 17

what is known as the extrinsic pathway

Answer 17

3,7 and 10 activation

Question 18

what does 10 activate

Answer 18

a little bit f thrombin

Question 19

what does thrombin do

Answer 19

gets the intrinsic pathway wokrforce going

Question 20

what does thrombin activate

Answer 20

5,7,8,11,13

Question 21

how do the fibrin strands hold otgethr

Answer 21

by crosslinks to form a tight mesh enabled by 13

Question 22

vitamin k dependant clotting factors

Answer 22

1972- I,IX,VII,X

Question 23

action of warfarin

Answer 23

inhibits vitamin k