Clotting Cascade Flashcards
1
Q
What are the 3 pathways in the clotting cascade?
A
Intrinsic
Extrinsic
Common (where other 2 pathways merge)
2
Q
How is the extrinsic pathway triggered?
A
External trauma causing blood loss
3
Q
How is the intrinsic pathway triggered?
A
Internal damage to the vessel wall
4
Q
How is the intrinsic pathway triggered?
A
Damaged endothelium exposes negatively charged collagen which activates factor XII
5
Q
What does thrombin aka factor IIa do in the cascade?
A
Converts fibrinogen into fibrin
6
Q
What does factor Xa do in the clotting cascade?
A
Converts prothrombin into thrombin
7
Q
What does antithrombin do in the clotting cascade?
A
Inactivates Xa and IIa (thrombin)
8
Q
Where do the following drugs affect the clotting cascade Heparin LMWH Xarelto Eliquis Pradaxa Warfarin
A
AT AT Xa Xa IIa (thrombin) II, VII, IX, X (vit k antagonist which prevents these from activation)
