Clotting

Question 1

Vitamin K antagonists - antithromvotic

Answer 1

Warfarin
Nicoumalone
Phenindone

Question 2

Vitamin k antagonists — moa

Answer 2

Block reduction of vit k epoxide = a cofactor in the production of factors 2,7,9,10

Question 3

Vitamin k antagonists - indication

Answer 3

Prophylaxis -

Dvt/pe/af clot/rheumatic disease/prosthetic valves

Question 4

Vit k antagonist - adverse

Answer 4

Haemorrhage /

don’t give if HTN, pregnant, peptic ulcers cerebral thrombosis / peripheral artery occlusion

Question 5

Heparin / LMWH- moa

Answer 5

Heparin activates antithrombin 3 = limits clotting by inactivating thrombin/factor X. Inhibits platelet aggregation. LMWH = similar but can be given less frequently and dosing more predictable

Question 6

Heparin/LMWH - indication

(Clexane) - enoxaparin

Answer 6

Treating dvt and pe

Prophylaxis against post op dvt and pe

Question 7

Heparin/LMWH- contraindication

Answer 7

Heparin no given to patients with HAEMOPHILLIA / THROMBOCYTOPENIA / PEPTIC ULCERS

advertse affects

• haemorrhage ( can stop infusion or give heparin antagonist e.g. protamine sulphate)
• thrombocytopenia
• hypersensitivity reactions

Question 8

LMWH /heparin -region

Answer 8

LMWH - once daily sub cut

Heparin - iv infusion or sub cut 12 hrs

Question 9

Vitamin K antagonists - antithromvotic

Answer 9

Warfarin
Nicoumalone
Phenindone

Question 10

Vitamin k antagonists — moa

Answer 10

Block reduction of vit k epoxide = a cofactor in the production of factors 2,7,9,10

Question 11

Vitamin k antagonists - indication

Answer 11

Prophylaxis -

Dvt/pe/af clot/rheumatic disease/prosthetic valves

Question 12

Vit k antagonist - adverse

Answer 12

Haemorrhage /

don’t give if HTN, pregnant, peptic ulcers cerebral thrombosis / peripheral artery occlusion

Question 13

Heparin / LMWH- moa

Answer 13

Heparin activates antithrombin 3 = limits clotting by inactivating thrombin/factor X. Inhibits platelet aggregation. LMWH = similar but can be given less frequently and dosing more predictable

Question 14

Heparin/LMWH - indication

(Clexane) - enoxaparin

Answer 14

Treating dvt and pe

Prophylaxis against post op dvt and pe

Question 15

Heparin/LMWH- contraindication

Answer 15

Heparin no given to patients with HAEMOPHILLIA / THROMBOCYTOPENIA / PEPTIC ULCERS

advertse affects

• haemorrhage ( can stop infusion or give heparin antagonist e.g. protamine sulphate)
• thrombocytopenia
• hypersensitivity reactions

Question 16

LMWH /heparin -region

Answer 16

LMWH - once daily sub cut

Heparin - iv infusion or sub cut 12 hrs

Question 17

LMWH /heparin -region

Answer 17

LMWH - once daily sub cut

Heparin - iv infusion or sub cut 12 hrs

Question 18

Heparin/LMWH- contraindication

Answer 18

Heparin no given to patients with HAEMOPHILLIA / THROMBOCYTOPENIA / PEPTIC ULCERS

advertse affects

• haemorrhage ( can stop infusion or give heparin antagonist e.g. protamine sulphate)
• thrombocytopenia
• hypersensitivity reactions

Question 19

Heparin/LMWH - indication

(Clexane) - enoxaparin

Answer 19

Treating dvt and pe

Prophylaxis against post op dvt and pe

Question 20

Heparin / LMWH- moa

Answer 20

Heparin activates antithrombin 3 = limits clotting by inactivating thrombin/factor X. Inhibits platelet aggregation. LMWH = similar but can be given less frequently and dosing more predictable

Question 21

Vit k antagonist - adverse

Answer 21

Haemorrhage /

don’t give if HTN, pregnant, peptic ulcers cerebral thrombosis / peripheral artery occlusion

Question 22

Vitamin k antagonists - indication

Answer 22

Prophylaxis -

Dvt/pe/af clot/rheumatic disease/prosthetic valves

Question 23

Vitamin k antagonists — moa

Answer 23

Block reduction of vit k epoxide = a cofactor in the production of factors 2,7,9,10

Question 24

Vitamin K antagonists - antithromvotic

Answer 24

Warfarin
Nicoumalone
Phenindone