clot lysis Flashcards
1
Q
examples of GPIIb/IIIa antagonists
A
eptifibatide
tirofivan
abciximab
2
Q
eptifibatide
A
cyclic heptapeptide inhibitor
3
Q
tirofivan - what, use
A
- non-peptide inhibitor used like older drug heparin
- for prevention of myocardial infarction if angina, and recent MI
4
Q
abciximab - what, use
A
- mAb against receptor
- also binds vitronectin on platelets (cell adhesion), endothelial cells + vascular smooth muscle cells
- used for coronary angioplasty for coronary artery thrombosis
5
Q
heparin - produced by, action
A
- by basophils and mast cells
- binds to AT-III > conformational change > inactivated thrombin and factor Xa
6
Q
name a LMW heparin
A
dalteparin
7
Q
warfarin inhibits synthesis of
A
- clotting factors 2, 7, 9, 10
- regulatory factors proteins C, S, Z
8
Q
other drugs
A
- dabigatran
- rivaroxaban
- apixaban
- edoxaban
- fondaparinux
- agratroban
- bivalirudin
- danaparoid
DR Annoying Earphones Found Amy’s Blind Dad
9
Q
dabigatran
A
inhibits thrombin
10
Q
inhibit factor Xa
A
- rivaroxaban
- apixaban
- edoxaban
- fondaparinux (indirect)
11
Q
argatroban
A
direct thrombin inhibitor (for HIT)
12
Q
bivalirudin
A
thrombin inhibitor
13
Q
danaparoid
A
indirect inactivator of Xa, direct inhibitor of thrombin activation of factor IX (for HIT)
