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MRCP > Clinical Sciences > Flashcards

Clinical Sciences Flashcards

1
Q

Alcoholic with symmetrical rash and D&V

A

Pellagra- niacin deficiency

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2
Q

Which virus is a risk factor for oropharyngeal cancer

A

HPV16/18

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3
Q

Most common cause of down syndrome on a cellular level

A

Maternal nondysjunction

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4
Q

Which test is used for before and after data

A

Wilcoxon signed rank test

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5
Q

Correlation - parametric (normally distributed) coefficient

A

Pearons

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6
Q

Correlation- non parametric coefficient

A

Spearmans

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7
Q

Tall, long fingered, downward lens dislocation, learning difficulties, DVT

A

Homocystinuria

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8
Q

Riboflavin

A

Angular Chellitis

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9
Q

Which cell is involved with hyperacute organ rejection

A

B Cells

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10
Q

Turners

A

Short
Shield chest, wide spaced nipples
Bicuspid aortic valve

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11
Q

Which receptor does insulin bind to

A

Tyrosine kinase

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12
Q

What is the power in statistics

A

the probability of (correctly) rejecting the null hypothesis when it is false

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13
Q

What do central chemoreceptors respond to

A

pH

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14
Q

What do peripheral chemoreceptors respond to

A

pO2

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15
Q

What receptors do adrenaline work on

A

G protein-coupled receptors

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16
Q

HLA B27

A

Ank Spond
Reactive arthritis
Psoriatic arthritis

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17
Q

HLA DQ2/DQ8

A

Coeliac

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18
Q

HLA-DR2

A

Narcolepsy
Goodpastures

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19
Q

HLA DR3

A

dermatitis herpetiformis
Sjogren’s syndrome
primary biliary cirrhosis

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20
Q

HLA DR4

A

type 1 diabetes mellitus*
rheumatoid arthritis

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21
Q

Early onset breast cancer, leukaemia and sarcoma

A

Li-Fraumeni - p53

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22
Q

Which complement deficiency predisposes to Meningitis

A

C5-9

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23
Q

Which clotting factors come from vitamin K

A

1972
10, 9, 7, 2

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24
Q

X linked conditions

A

Duchenne/Becker, haemophilia, G6PD

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25
Q

Developmental delay and cherry red spot

A

Tay Sachs

26
Q

Anti-A and Anti-B antibodies are which type of Ig

A

IgM

27
Q

Pregnant woman who works in pet shelter, baby with eye problems

A

Toxoplasmosis gondii parasite

28
Q

Standard error of the mean calculation

A

standard deviation / square root (number of patients)

29
Q

Which vitamin aids iron absorption

A

Ascorbic acid (vit c)

30
Q

Which Ig is associated with B Cells

A

IgD

31
Q

Which statistical test for two lots of ratios or percentages

A

chi squared test

32
Q

IPAP and EPAP scores

A

IPAP 10 cm h2o
EPAP 5cm h2o

33
Q

Upper zone fibrosis

A

Silica, TB, Ank spond

34
Q

Lower zone fibrosis

A

Asbestosis

35
Q

Which condition can be exposed when montelukast is stopped

A

Chung Strauss

36
Q

Meigs syndrome

A

Ascites, Pleural Effusion and benign ovarian tumour

37
Q

Catamenial Pneumothorax

A

Monthly right sided chest pain in menstruating women

38
Q

Bronchiectasis most common organism

A

Haemophilus Influenza

39
Q

What is the follow up for pleural plaques

A

Nothing, they are benign

40
Q

Warfarin and severe head bleeding or head injury what do you give

A

Prothrombin and vitamin k

41
Q

Acute management of gout

A

NSAIDs or colchicine

42
Q

Investigation if suspect spinal mets

A

MRI whole spine

43
Q
A
44
Q

What causes hypotension in sepsis

A

Increased production of IL1

45
Q

What does a funnel plot show

A

Publication bias in meta analyses

46
Q

How long off driving after cardiac procedures

A

1 week

47
Q

Threshold for being worried about LFT rise

A

3x

48
Q

Which ion channel prolongs the QT interval

A

Potassium

49
Q

How do ticagrelor and clopidogrel work

A

PGY12 receptor antagonist

50
Q

Antithrombotic therapy for bioprosthetic

A

Aspirin

51
Q

Antithrombotic therapy for mechanical valves

A

Warfarin and aspirin (2-3)

52
Q

HOCM is usually due a mutation coding for what

A

Beta myosin heavy chain protein

53
Q

Biggest risk factor for reforming of plaque following PCI

A

Premature withdrawal of antiplatelet

54
Q

High INR and major bleeding management

A

Stop warfarin, give IV Vit K 5mg, prothrombin complex concentrate

55
Q

Most specific ECG finding for pericarditis

A

PR depression

56
Q

Which molecule’s build up causes the ACE-I associated cough

A

Bradykinin

57
Q

What pulse do you get with mixed aortic valve disease

A

Bisferiens pulse

58
Q

Ivabrine side effect

A

It is given for angina. Side effect is visual disturbances

59
Q

S3
What is it caused by
When can it be heard

A

Caused by diastolic filling of ventricle
Heard in LV failure and pericarditis, considered normal in under 30s

60
Q

S4
What is it caused by and when is it heard

A

MRCP (1 decks)

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