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Clinical Sciences Flashcards

1
Q

Alcoholic with symmetrical rash and D&V

A

Pellagra- niacin deficiency

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2
Q

Which virus is a risk factor for oropharyngeal cancer

A

HPV16/18

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3
Q

Most common cause of down syndrome on a cellular level

A

Maternal nondysjunction

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4
Q

Which test is used for before and after data

A

Wilcoxon signed rank test

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5
Q

Correlation - parametric (normally distributed) coefficient

A

Pearons

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6
Q

Correlation- non parametric coefficient

A

Spearmans

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7
Q

Tall, long fingered, downward lens dislocation, learning difficulties, DVT

A

Homocystinuria

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8
Q

Riboflavin

A

Angular Chellitis

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9
Q

Which cell is involved with hyperacute organ rejection

A

B Cells

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10
Q

Turners

A

Short
Shield chest, wide spaced nipples
Bicuspid aortic valve

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11
Q

Which receptor does insulin bind to

A

Tyrosine kinase

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12
Q

What is the power in statistics

A

the probability of (correctly) rejecting the null hypothesis when it is false

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13
Q

What do central chemoreceptors respond to

A

pH

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14
Q

What do peripheral chemoreceptors respond to

A

pO2

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15
Q

What receptors do adrenaline work on

A

G protein-coupled receptors

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16
Q

HLA B27

A

Ank Spond
Reactive arthritis
Psoriatic arthritis

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17
Q

HLA DQ2/DQ8

A

Coeliac

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18
Q

HLA-DR2

A

Narcolepsy
Goodpastures

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19
Q

HLA DR3

A

dermatitis herpetiformis
Sjogren’s syndrome
primary biliary cirrhosis

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20
Q

HLA DR4

A

type 1 diabetes mellitus*
rheumatoid arthritis

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21
Q

Early onset breast cancer, leukaemia and sarcoma

A

Li-Fraumeni - p53

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22
Q

Which complement deficiency predisposes to Meningitis

A

C5-9

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23
Q

Which clotting factors come from vitamin K

A

1972
10, 9, 7, 2

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24
Q

X linked conditions

A

Duchenne/Becker, haemophilia, G6PD

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25
Developmental delay and cherry red spot
Tay Sachs
26
Anti-A and Anti-B antibodies are which type of Ig
IgM
27
Pregnant woman who works in pet shelter, baby with eye problems
Toxoplasmosis gondii parasite
28
Standard error of the mean calculation
standard deviation / square root (number of patients)
29
Which vitamin aids iron absorption
Ascorbic acid (vit c)
30
Which Ig is associated with B Cells
IgD
31
Which statistical test for two lots of ratios or percentages
chi squared test
32
IPAP and EPAP scores
IPAP 10 cm h2o EPAP 5cm h2o
33
Upper zone fibrosis
Silica, TB, Ank spond
34
Lower zone fibrosis
Asbestosis
35
Which condition can be exposed when montelukast is stopped
Chung Strauss
36
Meigs syndrome
Ascites, Pleural Effusion and benign ovarian tumour
37
Catamenial Pneumothorax
Monthly right sided chest pain in menstruating women
38
Bronchiectasis most common organism
Haemophilus Influenza
39
What is the follow up for pleural plaques
Nothing, they are benign
40
Warfarin and severe head bleeding or head injury what do you give
Prothrombin and vitamin k
41
Acute management of gout
NSAIDs or colchicine
42
Investigation if suspect spinal mets
MRI whole spine
43
44
What causes hypotension in sepsis
Increased production of IL1
45
What does a funnel plot show
Publication bias in meta analyses
46
How long off driving after cardiac procedures
1 week
47
Threshold for being worried about LFT rise
3x
48
Which ion channel prolongs the QT interval
Potassium
49
How do ticagrelor and clopidogrel work
PGY12 receptor antagonist
50
Antithrombotic therapy for bioprosthetic
Aspirin
51
Antithrombotic therapy for mechanical valves
Warfarin and aspirin (2-3)
52
HOCM is usually due a mutation coding for what
Beta myosin heavy chain protein
53
Biggest risk factor for reforming of plaque following PCI
Premature withdrawal of antiplatelet
54
High INR and major bleeding management
Stop warfarin, give IV Vit K 5mg, prothrombin complex concentrate
55
Most specific ECG finding for pericarditis
PR depression
56
Which molecule’s build up causes the ACE-I associated cough
Bradykinin
57
What pulse do you get with mixed aortic valve disease
Bisferiens pulse
58
Ivabrine side effect
It is given for angina. Side effect is visual disturbances
59
S3 What is it caused by When can it be heard
Caused by diastolic filling of ventricle Heard in LV failure and pericarditis, considered normal in under 30s
60
S4 What is it caused by and when is it heard

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