Clinical pharmacology and toxicology Flashcards
1
Q
What is the global mechanism fro Quinolone antibiotics?
A
Bactericidal
2
Q
How do Quinolones work as antibiotics?
A
Inhibit DNA through inhibiting topoisomerase II/IV
3
Q
How do bacteria develop resistance to Quinolone antibiotics?
A
Production of efflux pumps, to reduce intracellular concentrations of quinolones
4
Q
What adverse features are seen with Quinolone antibiotics? (4)
A
1) Lower seizure threshold
2) Tendon damage, especially the achilles
3) Cartilage damage
4) Prolonged QT interval
5
Q
What are the contraindications to quinolone antibiotics? (2)
A
1) Pregnancy or breastfeeding
2) G6PD deficiency
