Clinical Pharmacology and Administration of Fluid, Blood, Electrolyte and Blood Component Solutions Flashcards
Synthetic colloids
-Macromolecular particles suspended in a crystalloid fluid solution
Colloid oncotic pressure
Osmotic pressure generated by colloids in solution - is determined by the number of particles rather than their size
Clinical use of colloids
- Patients requiring oncotic support (hypoproteinemia)
to prevent interstitial fluid accumulation
-Hypovolemic patients as resuscitation
Classification of colloids
Blood component products or synthetic compounds composed of three major groups:
- HES derivatives
- Dextrans
- Gelatins
MOA colloids
In absence of increased microvascular permeability, movement is limited across the endothelium and less able to accumulate in the interstitium
- -Results in longer dwell time within the IVF compartment compared to crystalloids
- -Can pull fluid into IVF compartment based on their oncotic properties
Electrolytes: 0.45% NaCl
(mEq/L) Na 77 Cl 77 K 0 Ca 0 Mg 0
Electrolytes: 0.9% NaCl with 2.5% dextrose
(mEq/L) Na 77 Cl 77 K 0 Ca 0 Mg 0
Electrolytes: Plasmalyte M with 5% dextrose
(mEq/L) Na 40 Cl 40 K 16 Ca 5 Mg 3
Electrolytes: Normosol-M with 5% dextrose
(mEq/L) Na 40 Cl 40 K 13 Ca 0 Mg 3
Electrolytes: 5% dextrose
(mEq/L) Na 0 Cl 0 K 0 Ca 0 Mg 0
Electrolytes: plasma
(mEq/L) Na 142 Cl 104 K 5 Ca 5 Mg 3
Buffers (mEq/L): 0.45% NaCl
Lactate 0
Acetate 0
Gluconate 0
Buffers (mEq/L): 0.45% NaCl with 2.5% dextrose
Lactate 0
Acetate 0
Gluconate 0
Buffers (mEq/L): Plasmalyte M with 5% dextrose
Lactate 12
Acetate 12
Gluconate 0
Buffers (mEq/L): Normosol M with 5% dextrose
Lactate 0
Acetate 16
Gluconate 0
Buffers (mEq/L): Dextrose 5%
Lactate 0
Acetate 0
Gluconate 0
Buffers (mEq/L): plasma
Bicarb = 24
Osmolarity (mOsm/L): 0.45% saline
154
Osmolarity (mOsm/L): 0.45% saline with 2.5% dextrose
280
Osmolarity (mOsm/L): Plasmalyte 5% dextrose
376
Osmolarity (mOsm/L): Normosol M 5% dextrose
364
Osmolarity (mOsm/L): Dextrose 5%
252