Clinical Pharmacology and Administration of Fluid, Blood, Electrolyte and Blood Component Solutions Flashcards

1
Q

Synthetic colloids

A

-Macromolecular particles suspended in a crystalloid fluid solution

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2
Q

Colloid oncotic pressure

A

Osmotic pressure generated by colloids in solution - is determined by the number of particles rather than their size

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3
Q

Clinical use of colloids

A
  • Patients requiring oncotic support (hypoproteinemia)
    to prevent interstitial fluid accumulation
    -Hypovolemic patients as resuscitation
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4
Q

Classification of colloids

A

Blood component products or synthetic compounds composed of three major groups:

  1. HES derivatives
  2. Dextrans
  3. Gelatins
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5
Q

MOA colloids

A

In absence of increased microvascular permeability, movement is limited across the endothelium and less able to accumulate in the interstitium

  • -Results in longer dwell time within the IVF compartment compared to crystalloids
  • -Can pull fluid into IVF compartment based on their oncotic properties
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6
Q

Electrolytes: 0.45% NaCl

A
(mEq/L)
Na 77
Cl 77
K 0
Ca 0
Mg 0
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7
Q

Electrolytes: 0.9% NaCl with 2.5% dextrose

A
(mEq/L)
Na 77
Cl 77
K 0
Ca 0
Mg 0
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8
Q

Electrolytes: Plasmalyte M with 5% dextrose

A
(mEq/L)
Na 40
Cl 40
K 16
Ca 5
Mg 3
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9
Q

Electrolytes: Normosol-M with 5% dextrose

A
(mEq/L)
Na 40
Cl 40
K 13
Ca 0
Mg 3
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10
Q

Electrolytes: 5% dextrose

A
(mEq/L)
Na 0
Cl 0
K 0
Ca 0
Mg 0
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11
Q

Electrolytes: plasma

A
(mEq/L)
Na 142
Cl 104
K 5
Ca 5
Mg 3
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12
Q

Buffers (mEq/L): 0.45% NaCl

A

Lactate 0
Acetate 0
Gluconate 0

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13
Q

Buffers (mEq/L): 0.45% NaCl with 2.5% dextrose

A

Lactate 0
Acetate 0
Gluconate 0

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14
Q

Buffers (mEq/L): Plasmalyte M with 5% dextrose

A

Lactate 12
Acetate 12
Gluconate 0

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15
Q

Buffers (mEq/L): Normosol M with 5% dextrose

A

Lactate 0
Acetate 16
Gluconate 0

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16
Q

Buffers (mEq/L): Dextrose 5%

A

Lactate 0
Acetate 0
Gluconate 0

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17
Q

Buffers (mEq/L): plasma

A

Bicarb = 24

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18
Q

Osmolarity (mOsm/L): 0.45% saline

A

154

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19
Q

Osmolarity (mOsm/L): 0.45% saline with 2.5% dextrose

A

280

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20
Q

Osmolarity (mOsm/L): Plasmalyte 5% dextrose

A

376

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21
Q

Osmolarity (mOsm/L): Normosol M 5% dextrose

A

364

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22
Q

Osmolarity (mOsm/L): Dextrose 5%

A

252

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23
Q

Osmolarity (mOsm/L): Plasma

A

300

24
Q

pH: 0.45% saline

A

5.0

25
Q

pH: 0.45% saline with 2.5% dextrose

A

4.5

26
Q

pH: Plasmalyte 5% dextrose

A

5.5

27
Q

pH: Normosol M 5% dextrose

A

5.5

28
Q

pH: Dextrose 5%

A

4.0

29
Q

pH: plasma 7.4

A

7.4

30
Q

Glucose (g/L): 0.45% saline

A

0

31
Q

Glucose (g/L): 0.45% saline with 2.5% dextrose

A

25

32
Q

Glucose (g/L): Plasmalyte 5% dextrose

A

50

33
Q

Glucose (g/L): Normosol M 5% dextrose

A

50

34
Q

Glucose (g/L): Dextrose 5%

A

50

35
Q

Glucose (g/L): plasma 7.4

A

NA

36
Q

Electrolytes 0.9% NaCl

A
(mEq/L)
Na 154
Cl 154
K 0
Ca 0
Mg 0
37
Q

Buffers 0.9% NaCl

A

Lactate 0
Acetate 0
Gluconate 0

38
Q

Osmolarity (mOsm/L) NaCl

A

308

39
Q

pH NaCl

A

5.0

40
Q

Electrolytes LRS

A
Na 130
Cl 109
K 4
Ca 3
Mg 0
41
Q

Buffers LRS

A

Lactate 28
Acetate 0
Gluconate 0

42
Q

Osmolarity (mOsm/L) LRS

A

272

43
Q

pH LRS

A

6.5

44
Q

Electrolytes Plasmalyte 148

A
Na 154
Cl 154
K 0
Ca 0
Mg 0
45
Q

Buffers Plasmalyte 148

A

Lactate 0
Acetate 27
Gluconate 23

46
Q

Osmolarity (mOsm/L) Plasmalyte 148

A

294

47
Q

pH Plasmalyte 148

A

5.5

48
Q

Electrolytes Normosol-R

A
Na 140
Cl 98
K 5
Ca 0
Mg 3
49
Q

Buffers Normosol-R

A

Lactate 0
Acetate 27
Gluconate 23

50
Q

Osmolarity (mOsm/L) Normosol-R

A

294

51
Q

pH Normosol-R

A

6.4

52
Q

Electrolytes Plasmalyte-A

A
Na 140
Cl 98
K 5
Ca 0
Mg 3
53
Q

Buffers Plasmalyte-A

A

Lactate 0
Acetate 27
Gluconate 23

54
Q

Osmolarity (mOsm/L) Plasmalyte-A

A

294

55
Q

pH Plasmalyte-A

A

5.5 (?)