Clinical Pharmacokinetics I

Question 1

the plasma concentration of a drug is a function of which 3 rates?

Answer 1

• the rate of input of the drug into the plasma
• the rate of distribution of the drug into the tissues
• the rate of elimination of the drug

Question 2

equation for volume of distribution?

Answer 2

Question 3

drugs that are completely retained within the vascular compartment have a ____ Vd equal to the vascular compartment

Answer 3

drugs that are completely retained within the vascular compartment have a minimum Vd equal to the vascular compartment

Question 4

drugs that have much higher concentrations in the extravascular tissue than in the vascular compartment have a ____ Vd

Answer 4

drugs that have much higher concentrations in the extravascular tissue than in the vascular compartment have a very high Vd

Question 5

Answer 5

Question 6

Answer 6

Question 7

if we want to achieve quickly a target plasma drug concentration, the dose can be calculated with which equation?

Answer 7

dose = Vd x TC (target concentration)

Question 8

for a drug eliminated with first-order kinetics, ____ is a constant

Answer 8

for a drug eliminated with first-order kinetics, clearance is a constant

Question 9

Answer 9

Question 10

what is the equation for half-life?

Question 11

what is the only factor (according to the chart) that decreases half-life?

Answer 11

CYP induction

Question 12

which 3 drugs exhibit saturation (zero-order) kinetics?

Answer 12

aspirin (at high doses)

ethanol

phenytoin

Question 13

in zero-order: a constant ___ of drug is eliminated per unit time

in first-order: a constant ____ of drug is eliminated per unit time

Answer 13

in zero-order: a constant amount of drug is eliminated per unit time

in first-order: a constant fraction of drug is eliminated per unit time