Clinical Implications of Gene Exchange

Question 1

ClinImp of GenEx (A)-location

Answer 1

-Bacteria co-existing in lower GI-tract soil, or other environments can exchange DNA encoding diverse AB resistance

Question 2

ClinImp of GenEx (D)-SOLUTIONS

Answer 2

SOLUTION to maintaining long-term effective use of therapeutic agents lies in better, more prudent use of AB in human and animal health care

Question 3

ClinImp of GenEx (B)-Stability

Answer 3

-DNA is stable in the environment especially when attached to particulate matter.

Question 4

ClinImp of GenEx (C)-Contamination

Answer 4

• AB preparations often contaminated with DNA that encode resistance genes
• Contamination INCREASES the chance of genetic exchange via TRANSFORMATION between AB-producing organisms and the pathogens they are being used to control