Clinical features

Question 1

what is the most common initial symptom in GPA?

Answer 1

upper airway inflammation

Question 2

what are different mechanisms of hearing loss in GPA?

Answer 2

Inflammation of the middle ear or
Inflammation of the auditory tube or
by obstruction of the tube at its entry into the nose

Question 3

what is the prevalence of subglottic inflammation in GPA?

Answer 3

15%

Question 4

indcidence of eye and orbital involvement in GPA?

Answer 4

30-60%, MC being conjunctivitis and episcleritis

Question 5

GPA - orbital peudotumor incidence ?

Answer 5

6-15%

Question 6

Lung manifestations in GPA?

Answer 6

1. Nodular cavitating disease
2. diffuse pulmonary haemorrhage
3. pleuritis
4. subglottic involvement
5. Pulmonary capillaritis - GGOs and pulmonary fibrosis
6. bronchectasis

Question 7

what is the characteristic pattern of arthritis in GPA?

Answer 7

migratory arthralgia which is predominantly large joint type

Question 8

Different cutaneous manifestations in GPA?

Answer 8

Purpura, papules, vesicles/bullae, ulcers, digit ischemia, subcutaneous nodules, and livedo racemosa have all been reported

Question 9

what is the characteristic skin manifestation in GPA?

Answer 9

Superficial, nonerythematous cutaneous nodule with pathologic findings showing a necrotizing, palisading granuloma

But this lesion is also seen in EGPA and other systemic diseases

Question 10

features of glomerulonephritis in GPA?

Answer 10

In 50% of patients during course of illness

seldom hematuria, mostly detected incidentally during uremia

pauci immune and is frequently necrotizing and crescentic

Question 11

what are different clinical manifestations more in MPA than in GPA ?

Answer 11

Glomerulonephritis MPA&raquo_space; GPA at diagnosis
Cutaneous vasculitis MPA = GPA
Neuropathy MPA = GPA
Constitutional MPA = GPA
MSK symptoms MPA = GPA
GI, Cardiac No conclusive evidence
Pulmonary fibrosis MPA&raquo_space; GPA (Japan and china)

Question 12

characteristics of renal manifestations in MPA ?

Answer 12

Typically present at more advanced stage of renal failure, histologically renal damage at presentation is worse

Question 13

what is the incidence of anti-MPO positivity in EGPA?

Answer 13

40%

Question 14

In how many percent of patients the three characteristic manifestations in Biopsy of GPA seen ?

Answer 14

10%

Question 15

what are the three characteristic manifestations of GPA on biopsy?

Answer 15

Granulomatous inflammation, necrosis, and small-vessel vasculitis

Question 16

what is the difference in antibody positivity in different organ manifestation in AAV?

Answer 16

Only 60% to 70% of patients with disease limited to the upper airway test positive for antibodies to PR3 or MPO, in contrast to 90% or more with systemic vasculitis.