Clinical Cytogenetics

Question 1

What are the indications for cytogenic analysis?

Answer 1

1) Problems with early childhood growth and development
2) still births and neonatal deaths
3) history of infertility and miscarriage
4) known suspected chromosome abnormality
5) maternal age greater than 35
6) cancer (chromosomal analysis of cancerous tissue)

Question 2

What are common cell types and their sources used for cytogenic analysis?

Answer 2

1) White blood cells (T-lymphocytes)
2) amniotic cells
3) Cells of the chronic villus
4) fibroblasts (skin biopsy)
5) cancer cells (tumor biopsy)
6) bone marrow cells (for hematological malignancies)