Clinical Case Discussion - Pharmacogenetics Flashcards
1
Q
What is the animal-plant warfare hypothesis?
A
Each developed mechanisms to protect self from other species
Plants - poisons
Humans - Mechanisms to detox self
2
Q
What is the typical course of metabolism of drugs?
A
Phase I using Cytochrome P450 3A
3
Q
What type of polymorphisms typically have clincally relevant effects?
A
Polymorphisms in transporters and drug metabolizing enzymes
4
Q
Why are polymorphisms in drug targets typically clinically irrelevant?
A
There is no clinical effect because the targets are so highly preserved
5
Q
What are toxicity targets and why are they clinically relevant?
A
Toxicity targets are targets that result in adverse effects for a patient. Drugs w/i a class have varying affinities for these toxicity targets.
