CLINICAL CARE OF PSYCHIATRIC DISORDERS Flashcards
What is the complex somatic, cognitive, affective, and behavioral effects of psychological trauma?
PTSD
True or False
PTSD has a strong correlation with TBI
True
PTSD
One study of hospitalized soldiers showed an increased prevalence of ____% at one month versus _____% at 4 months of exposure
- 4.2%
2. 12.2%
True or False
A study of 1648 US marines showed that experiencing a TBI during deployment was a strong predictor of PTSD symptom development
True
PTSD
Studies using MRI have shown decreased volume in several areas of the brain such as what?
- Left amygdala (fear center)
- Hippocampus (memories)
- Anterior cingulate cortex
The following can be common clinical manifestations of what psychiatric disorder?
- Affective dysregulation (anger common)
- Cognitive impairment
- Several behavior responses in response to regular stimuli:
a. flashbacks
b. severe anxiety symptoms
c. fleeing
d. combative behaviors
PTSD
True or False
Clinical manifestations of PTSD can lead to compensatory behaviors in the individuals affected. (avoidance of triggering experiences)
True
Avoidance leads to furthering of symptoms such as emotional numbing, diminished interests in activities and detachment from others
Symptoms of PTSD must be present for at least how many weeks following trauma for psychiatry to make the diagnosis?
Four weeks
True or False
The focus of the IDC for PTSD is screening
True
What are some forms of psychotherapy that are useful in the treatment of PTSD?
- Exposure Therapy
- CBT (cognitive behavioral therapy)
- EMDR (Eye Movement Desensitization and Reprocessing)
True or False
Since marital problems and substance abuse are commonly seen in patients with PTSD should also consider referral sources for counseling
True
What is the first line therapy of choice for PTSD?
Antidepressant Medications (SSRIs)
Example: Sertraline
PTSD
What adjunctive medication can be used for nightmares?
Prazosin
PTSD
What adjunctive medication can be used for tremors and sympathetic responses?
Beta Blockers
PTSD
What adjunctive medication can be used for comorbid psychosis if needed?
Antipsychotics
What is a persistent disturbance of eating that impairs both health and psychological functioning?
Eating disorders
What are some examples of eating disorders?
- Anorexia nervosa
- Bulimia nervosa
- Binge eating disorder
- Pica
- Rumination disorder
In regards to eating disorders, you should consider a broad differential when evaluating a patient for weight loss, examples include but are not limited to what?
- Hyperthyroidism
- Malignancy
- Disease of the GI tract
- Chronic Infectious Diseases
- Affective disorders (depression)
What is the estimated lifetime prevalence of Anorexia Nervosa and is likely higher due to the concealment of the illness?
0.6%
Who is Anorexia Nervosa more common in?
Women
Ratio ranges from 10-20:1
What is the median age of onset for Anorexia Nervosa?
18 years old
In what psychiatric condition is there an intense fear of gaining weight or becoming fat or persistent behavior that prevents weight gain, despite being underweight?
Anorexia Nervosa
What is the distorted perception of body weight and shape, undue influence of weight and shape on self-worth, or denial of the medical seriousness of one’s own low body weight?
Anorexia Nervosa
These are all common physical exam findings of what psychiatric condition?
- Low BMI (<17.5)
- Emaciation
- Hypothermia
- Bradycardia
- Hypotension
- Hypoactive bowel sounds
- Xerosis (dry and scaly skin)
- Brittle hair and hair loss
- Lanugo body hair
- Abdominal distention
Anorexia Nervosa
What eating disorder has an estimated lifetime prevalence of 1.0% and is three times more common in women that in men (1.5% vs 0.5%)?
Bulimia Nervosa
What is known as recurrent episodes of binging and purging and inappropriate compensatory behavior to prevent weight gain?
Bulimia Nervosa
What psychiatric disorder is characterized by the following?
- Self-induced vomiting
- Misuse of laxatives
- Diuretic use
- Enemas
- Fasting
- Excessive exercise
* *7. Occurring on average at least once per week for three months
Bulimia Nervosa
Bulimia Nervosa
There is a mild psychosocial impairment seen in about ____% and severe impairment in ___%
- 78%
2. 16%
Are additional psychiatric disorders common with bulimia nervosa?
Yes
Anxiety, depression, PTSD, substance abuse, ADHD, conduct disorders, personality disorders
You may see the following in what psychiatric condition?
- Dehydration
- Menstrual irregularities
- Mallory-Weiss syndrome
- Pharyngitis
- Erosion of dental enamel
- ECG changes may occur
Bulimia Nervosa
True or False
Binge Eating Disorder
Eating is associated with: uncomfortably full, eating when not hungry, feelings of embarrassment, feelings of disgust and depression
True
What psychiatric disorder is characterized by the eating of non-food substances and can be associated with iron deficiency anemia?
PICA
What eating disorder is associated with repeated regurgitation of food?
Rumination Disorder
True or False
Once recognized eating disorders require referral
True
What psychiatric disorder is characterized by the following triad?
- Psychological dependence or craving
- Physiologic dependence
- Tolerance
Substance Use Disorder
What psychiatric disorder has a huge impact on our society with more than 85k deaths per year directly attributable to it and an annual economic cost of $250 billion?
Alcohol Use Disorder
True or False
1 in 10 deaths in working age adults results from excessive drinking
True
What is the 3rd leading preventable cause of death in the United States?
Alcohol Use Disorder
What refers to the consumption of alcohol that puts a patient at risk for health consequences?
Risky Alcohol Use
What is the amount of alcohol that increases health risks in men under the age of 65?
- More than 14 standard drinks per week on average
2. More than 4 drinks on any day
What is considered the standard drink?
- 5 oz of wine
2. 12 oz beer
What is the amount of alcohol that increases health risks in women and adults 65 and older?
- More than 7 standard drinks per week on average
2. More than 3 drinks on any day
What are some common medical complications of alcohol use?
- HTN
- Cardiovascular disease
- Liver disease
- Pancreatitis
- Gastritis
- Esophagitis
- Neuropathy
There is a strong association with what disorder and the following?
- Depression
- Anxiety
- PTSD
- Eating Disorders
- Other substance use disorders
- Sleep disturbances
- Suicidal Ideations and attempt
Alcohol Use Disorder
What is the estimated lifetime rate of suicide attempts with patients suffering from alcohol use disorder?
7%
What are some common physical exam findings you may see in a patient with alcohol use disorder?
- May have signs of withdrawal
a. tremor, agitation - Peripheral neuropathy
- Features of liver disease
a. hepatic/splenic enlargement
b. icterus/jaundice
c. spider angiomata
d. Palmar erythema
What are the questions you can ask a patient with possible alcohol use disorder?
“CAGE questions”
- Have you ever felt you should Cut down on your drinking?
- Have people Annoyed you by criticizing your drinking?
- Have you ever felt bad or Guilty about your drinking?
- Have you ever taken a drink first thing in the morning (Eye opener) to steady
your nerves or get rid of a hangover?
What is one complication of Alcohol use disorder that is due to a deficiency of Thiamine (Vitamin B1)?
Wernicke Korsakoff Syndrome
actually two separate syndromes
What is direct brain damage due to a deficiency of Thiamine and is characterized by the triad of encephalopathy, disorientation, inattentiveness, and oculomotor dysfunction ?
Wernicke Encephalopathy (WE)
The following are common findings in what syndrome that is associated with alcohol use disorder?
- Gait ataxia
- Wide based gait
- Most common symptom: Confusion
Wernicke Encephalopathy
What is a chronic neuro condition that is usually a consequence of Wernicke Encephalopathy?
Korsakoff Syndrome
What is a late neuropsychiatric manifestation of Wernicke’s Encephalopathy?
Korsakoff Syndrome
What does Korsakoff syndrome cause?
Anterograde and retrograde amnesia
True or False
Alcohol Withdrawal
Potentially life threatening problem, approximately half of patient experience some form of withdrawal, usually mild but estimated 20% experience severe symptoms
True
With mild alcohol withdrawal, symptoms generally begin within 6-24 hours of the last drink and may show things such as what?
- Anxiety
- Minor agitation
- Restlessness
- Insomnia
- Tremors
- Diaphoresis
- Palpitations
- Headache
- Alcohol craving
Mild withdrawal symptoms usually resolve in how long?
1-2 days
Can more severe symptoms of alcohol withdrawal include hallucinations and delirium?
Yes
When do hallucinations associated with alcohol withdrawal usually begin and resolve?
- Begins within 12-24 hours
2. Resolves in another 1-2 days
What are the seizures typically associated with alcohol withdrawal?
Tonicclonic
When do seizures associated with alcohol withdrawal typically occur?
6-48 hours after last drink
True or False
10-30% of patients with alcohol withdrawal will develop seizures
True
What is the “kindling effect” in regards to alcohol withdrawal?
Risk of seizures increases with repeated withdrawals
Delirium due to alcohol withdrawal begins within __ to ___ hours after the last drink and occurs in __% to __% of patients hospitalized with withdrawal?
- 72-96 hours
2. 1-4%
True or False
The term “Delirium Tremens” refers to the fluctuating disturbance in attention and cognition, may include hallucinations
True
Severe forms of what with alcohol withdrawal in severe forms can include agitation and extreme autonomic hyperactivity? (fever, tachycardia, hypertension, drenching sweats)
Delirium Tremens
What is the leading preventable causes of mortality worldwide, causes an estimated 6 million deaths worldwide, and 400k deaths annually?
Tobacco Use Disorder
What are some major causes of mortality associated with Tobacco Use Disorder?
- Cardiovascular Disease
- Pulmonary Disease
- Cancer
What is responsible for an estimated 33% of all cardiovascular related deaths in the US?
Tobacco Use Disorder
What is the most important risk factor for COPD?
Tobacco Use Disorder
What is the “Pre-contemplation” stage of quitting tobacco?
Not ready to quit
What is the “contemplation” stage of quitting tobacco?
Considering a quit attempt
What is the “preparation” stage of quitting tobacco?
Actively planning a quit attempt
What is the “Action” stage of quitting tobacco?
Actively involved in a quit attempt
What is the “maintenance” stage of quitting tobacco?
Achieved smoking cessation
Triggers to smoking are a huge barrier including things like smoking with the morning coffee, smoking while drinking, and around meal time; but what is perhaps the greatest barrier?
Nicotine Withdrawal
Nicotine withdrawal peaks in the first ____ days and then slowly subsides over the course of about ___ month(s)
- 3 Days
2. One month
What is the long acting treatment of nicotine withdrawal?
Nicotine Patch
What is the short acting treatment of nicotine withdrawal?
Gum or Lozenges
What medication used for the treatment of nicotine withdrawal has the following effects?
- Used for both depression and smoking cessation
- Considered an atypical antidepressant
- Inhibits reuptake of norepinephrine and dopamine as well as act as nicotinic receptor antagonist
- Reduces nicotine cravings and withdrawal symptoms
Buproprion (Wellbutrin)
What medication is a partial nicotine agonist, stimulates dopamine activity but to a much smaller degree than nicotine, and reduces cravings and withdrawal symptoms?
Varenicline (Chantix)
Effects from marijuana occur in ____ to ___ minutes and last ___ to ___ hours
- 10-20 minutes
2. 2-3 hours
Marijuana is detected in most urine tests for ___ to ___ days in short term users and ___ to __ days in long term users
- 4-6 days
2. 20-50 days
High doses of what produce transient psychotomimetic effects?
Marijuana
True or False
Marijuana frequently aggravates existing mental illness and adversely affects motor performance
True
True or False
It has been demonstrated that the rate of cannabis use is highest between the ages of 18 and 25 with approximately 18.7% of that population using at least once within
the past month, with use tapering off to 7% after age 26.
True
True or False
In 2018, an estimated 9.9 million people (aged 12 and older) misused prescription pain relievers and 808,000 people used heroin.
True
Approximately ___% of abused opioids ae obtained from family and friends
55%
What lab should always be checked in suspected opioid intoxication?
Serum Glucose
Hypoglycemia is not uncommon, rapidly correctable, and easily confused with acute opioid intoxication
Opioid Use Disorder
If a patient is found down you should consider rhabdomyolysis and run what what?
Serum CPK
What is the treatment of choice in the treatment of acute opioid intoxication?
Naloxone
What are some forms of stimulant drugs that activate the CNS with resulting strong rewarding effects (euphoria, “rush” and “high”) that contribute to high abuse liability?
Cocaine and amphetamines
True or False
Stimulant abuse is quite common, either alone or in combination with other drugs
True
True or False
Stimulants
Increase synaptic levels of monoamines (dopamine, serotonin, and norepinephrine) by blocking the monoamine transporters (cocaine, methylphenidate) or releasing monoamines (methamphetamine)
True
True or False
Stimulants
Increased dopamine levels in the mesolimbic dopamine pathway are believed to mediate the reinforcing effects of stimulants
True
True or False
Stimulants
Serotonergic activation mediates stimulant effects on mood. Alternatively, Norepinephrine mediates cognitive arousal and cardiovascular activation in response to stimulants, as well as stress response including stress-induced drug use/relapse
True
True or False
Stimulants
Increased sociability that is associated with acute intoxication may be mediated at least in part by acute release of the neuropeptide oxytocin
True
True or False
Stimulants
Cocaine blocks voltage-gated sodium ion channels, which underlies its anesthetic effect
True
Moderate use of what produces hyperactivity, a sense of enhanced physical and mental capacity, and sympathomimetic effects?
Stimulants
The clinical picture of what will show the following?
- Sweating
- Tachycardia
- Elevated blood pressure
- Mydriasis
- Hyperactivity
- Acute brain syndrome with confusion and disorientation
Acute Stimulant Intoxication
True or False
Clinicians should be alert to cocaine use in patients presenting with unexplained nasal bleeding, headaches, fatigue, insomnia, anxiety, depression, and chronic hoarseness.
True
What disorder has an estimated lifetime prevalence in the US of around 1-2% and is the 18th leading cause of disability in the US?
Bipolar Disorder
What is a mood disorder that is characterized by the following three different mood states?
- Mania
- Hypomania
- Major depression
Bipolar disorder
What is a distinct period of abnormally or persistently elevated, expansive, or irritable mood and persistently increased activity or energy, lasting at least one week and present moods of the day, nearly every day?
Mania
Three or more of the following symptoms must be present to diagnose a patient as having what?
- Inflated self-esteem or grandiosity
- Decreased need for sleep
- More talkative than usual or pressured speech
- Flight of ideas/racing thoughts
- Distractibility
- Increased goal directed activity
- Involvement in activities that carry negative potential (spending sprees, sexual indiscretions)
Mania
True or False
Mania can be severe enough to cause marked impairment in functioning or necessitate hospitalization to prevent harm to self or others, or there are psychotic features
True
The acronym “DIGFAST” is often used to remember the symptoms of mania, what does it stand for?
D- Distractibility I- Indiscretions G- Grandiosity F- Flight of Ideas A- Activity increase S- Sleeplessness T- Talkativeness
What has similar characteristics of mania only far less severe, there is no delusional grandiosity, thought form is more organized, there is less risky behavior, no psychotic symptoms, and no hallucinations?
Hypomania
Five or more of the following symptoms present during the same two week period could mean the patient is suffering from what?
- Depressed mood (sad, empty, hopelessness)
- Diminished interest in pleasurable activities
- Weight loss or weight gain
- Insomnia or hypersomnia
- Psychomotor agitation or retardation
- Decreased energy
- Guilt or feelings of worthlessness
- Impaired concentration
- Thoughts of death or thoughts of suicide
Major Depression
What should the IDC do for the management of Bipolar Disorder?
- Immediately refer and manage acute symptoms while awaiting referral
- If agitated try to talk them down or give antipsychotic medication for assistance
a. Haloperidol
Maintenance therapy for Bipolar Disorder will usually be employed by a psychiatrist with a mood stabilizer or antipsychotic such as what?
- Lithium
- Valproic Acid
- Lamotrigine (Lamictal)
- Quetiapine (Seroquel)