Clinical Aspects of Cancer Chemotherapy Flashcards
Regarding chemotherapy, define induction
First round of therapy
Regarding chemotherapy, define adjuvant.
Chemo given post - surgery
Regarding chemotherapy, define neoadjuvant
Chemo given pre - surgically
Regarding chemotherapy, define salvage
Chemo given as second or third round
What are the 2 examples of bifunctional alkylators provided as examples?
Ifosfamide and chlorambucil
Carmustine, lomustine, busulfan, dacarbazine, procarbazine. These all belong to what class of drugs _
Alkylators
In addition to daunorubicin and doxorubicin, the third example of an antitumor antibiotic provided was?
Dactinomycin
In addition to vincristine, vinblastine and paclitaxel, the fourth example of a mitotic spindle poison provided was _
Docetaxel
Regarding cyclophosphamide, what enzymes are responsible for its activation? What about its inactivation? What are the 2 products of its metabolism that are toxic?
Hepatic CYP 450s
Aldehyde dehydrogenase
Acrolein and phosphoramide mustard
What is the major site of metabolism of the anthracyclines and the vinca alkaloids? What about cisplatin?
Anthracycline and vincas - Liver
Cisplatin - Kidney
What are 2 specific toxicities associated with vincristine?
peripheral neuropathy
SIADH (syndrome of inappropriate antidiuretic hormone (ADH) secretion)
What is a specific toxicity associated with paclitaxel?
Neuropathy
What are 3 specific toxicities associated with bleomycin?
Pulmonary fibrosis
Fever
Anaphylaxis
What are 2 specific toxicities associated with methotrexate?
Renal dysfunction
Hepatic dysfunction
What is a specific toxicity associated with 5-fluorouracil?
Diarrhea
What are 2 specific toxicities associated with cytosine arabinoside?
Cerebellar dysfunction
Fever
What are 2 specific toxicities associated with cyclophosphamide?
Hemorrhagic cystitis
SIADH - like syndrome
What is a specific toxicity associated with bisulfan?
Pulmonary fibrosis
What is a specific toxicity associated with cisplatin and carboplatin?
Renal failure
What is a specific toxicity associated with the anthracyclines?
Cardiomyopathy
What is a specific toxicity associated with alkylating agents?
Secondary cancers
What is a specific toxicity associated with irinotecan? How can this be prevented? Accumulation of what metabolite causes this diarrhea?
Diarrhea
Atropine premedication, blocks muscarinic agonism
SN38 (glucuronide)
A common ending to the names of the tyrosine kinase inhibitors is _
-ib
What is the exception to the rule that majority of chemotherapeutic agents are myelosuppressive?
Vincristine
