Clinical Approach to Neurodevelopment + Attention Disorders Flashcards

1
Q

When do neurodevelopment disorders typically manifest? how are they characterized?

A

early in development, often before child enters grade school

characterized by developmental deficits that produce impairments of personal, social, academic or occupational functioning

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2
Q

What are the neurodevelopmental disorders?

A

Intellectual disability (intellectual development disorder)
Communication disorders (language, speech sound, childhood-onset fluency, social (pragmatic) communication)
Autism Spectrum Disorder
ADHD
Specific Learning Disorder
Motor disorders (developmental coordination, sterotypic movement, tic)

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3
Q

Intellectual disability (intellectual developmental disorder) is characterized by deficits in:

A

general mental abilities:

  • reasoning
  • problem solving
  • planning
  • abstract thinking
  • judgement
  • academic learning
  • learning from experience
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4
Q

The deficits in general mental abilities of intellectual disability result in what?

A

impairment of adaptive functioning (communication, social participation, academic or occupational functioning, personal independence at home or in community settings)

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5
Q

Global development delay dx is used for who?

A

individuals who are unable to undergo systematic assessments of intellectual functioning

aka too young to participate in standardized tests, acquired insult during developmental period, severe head injury

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6
Q

What are the two main deficits seen in intellecutal disabillity?

A

intellectual and adaptive functioning deficits in conceptual, social, and practical domains

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7
Q

What are the criteria that must be met for Intellectual disability?

A

A. deficits in intellectual functioning - reasoning, problem solving, planning, abstract thinking, etc.
B. deficits in adaptive functioning that result in failure to meet developmental and sociocultural standards for personal independence and social responsibility
C. onset of A + B deficits during the developmental period

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8
Q

What are the three domains of adaptive functioning deficits?

A

conceptual, social, and practical

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9
Q

What is the conceptual domain of adaptive fxning?

A

where conceptual skills lag markedly behind those of peers
preschoolers–> slow language/pre-academic skill develpt
school-age kids–> lagging progressing in reading, writing, math, time and money understanding
adults–> academic skill developt @ elementary level; support is required for all use of academic skills in work + personal life

TLTR- conceptual stuff is hard

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10
Q

What is the social domain of adaptive fxning?

A
  • difficulty developing age-mates, is immature in social interactions
  • difficulty accurately perceiving peers’ social cues
  • communication, conversation, and language are more concrete, less mature
  • difficulties regulating emotion + behavior are noticed by peers in social situations
  • social judgment is immature for age, person is at risk of being manipulated by others (gullible)

TLTR- social activity struggling, unawareness

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11
Q

What is the practical domain of adaptive fxning?

A
  • difficulty w/ age-approp personal care + complex daily living tasks in comparison to peers (ex. adults need help shopping)
  • difficulty making good decisions about personal well-being and recreational activities
  • competitive employment is restricted to jobs not emphasizing conceptual skills
  • individual usually needs support with health care decision + legal decisions + to learn to perform a skilled vocation competently
  • support typically needed to raise family

TLTR- NEED HELP W/ DAILY LIVING activities

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12
Q

language disorder, speech sound disorder, and social (pragmatic) communication disorder are characterized by what?

A

deficits in development and use of language, speech, and social communication, respectively

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13
Q

childhood-onset fluency disorder is characterized by what?

A

disturbances of normal fluency and motor production of speech (repetitive sounds or syllables, prolongation of consonants or vowel sounds, broken words, etc.)

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14
Q

assessments of speech, language, and communication abilities must take into account what?

A

the individual’s cultural and language context

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15
Q

Describe language disorder.

A

A. Persistent difficulties in the acquisition and use of language across modalities (i.e., spoken, written,
sign language, or other) due to deficits in comprehension or production
-include: reduced vocabulary, limited sentence structure, impairments in discourse (using vocab to connect sentences)

B. language abilities are substantially and quantifiably below those expected for age

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16
Q

Describe speech sound disorder.

A

Persistent difficulty with speech sound production that interferes with speech intelligibility or prevents verbal communication of messages.

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17
Q

Describe childhood-onset fluency disorder (stuttering):

A

Disturbances in the normal fluency and time patterning of speech that are inappropriate for the individual’s age and
language skills, persist over time, and are characterized by frequent and marked occurrences of one (or more) of the
following: sound syllable repetition, sound prolongation of consonants + vowels, broken words, audible or silent blocking, circumloculations, words produced w/ excess of physical tension, monosyllabic whole-word repetitions

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18
Q

Describe Social (pragmatic) communication disorder.

A

Persistent difficulties in the social use of verbal and nonverbal communication as manifested by all of the following: deficits in using communication for social purposes (appropriately), impairment of ability to change communication to meet needs of listener, difficulties following rules for convo and storytelling (ex. taking turns in convo), difficulties understanding whats not explicitly state (ex. making inferences) and nonliteral/ambiguous meanings of language

*similar to what people with ASD have (so have to rule that out)

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19
Q

What do all the communication disorders have in common?

A

the disturbances result in functional limitation of some sort, including social participation, academic achievement or occupational performance

onset of syx is in the early developmental period

symptoms are not attributable to another medical/neuro condition

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20
Q

What is the mc associated feature of social (pragmatic) communication disorder?

A

delay in reaching language milestones

more board question he said

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21
Q

Describe Autism Spectrum Disorder. (2 major criteria)

A

A. Persistent deficits in social communication and social interaction across multiple contexts, as manifested
by all of the following, currently or by history : 1)deficits in social-emotional reciprocity, 2) deficits in nonverbal communicative behaviors used for social interactions, 3) deficits in developing, maintaining, and understanding relationships

B. restricted, repetitive patterns of behavior, interests, or activities; 2 of the following: 1) stereotyped/repetitive motor movements, use of objects, and speech, 2) insistence of sameness, inflexibility, 3) highly restricted, fixated interests (abnormal in intensity), 4) hyper- or hyporeactivity to sensory input ** (cooley emphasized*) or unusual interest in sensory aspects of environment

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22
Q

What are some other criteria associated w/ ASD?

A
  • syx must be present in early devleopment period
  • syx cause clinically signif impairment in social, occupational, or other impt areas of functioning
  • disturbances aren’t better explained by intellectual disability or global developmental delay

*note: intellectual disability and ASD frequently co-occur

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23
Q

What is the severity of ASD based on?

A

social communication impairments + restricted, repetitive patterns of behavior

Level 1: “requiring support”
Level2: “requiring substantial support”
Level 3: “requiring very substantial support”

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24
Q

What is the most consistently useful behavioral intervention for ASD?

A

education + support for patients, siblings, teachers, and caregivers

-learn about “parallel process” (aka join w/ them, adopt), and learning how to use it for behavioral management

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25
Q

What medications work for ASD?

A

risperidone + aripiprazole = currently FDA approved for irritability + agitation associated w/ Autism

-other meds have evidence of efficacy (valproic acid, gabapentin, stimulants, alpha agonists, antidepressants)

26
Q

What do females w/ ADHD present like?

A

Females with ADHD present more commonly with the INATTENTIVE subtype than do boys

  • Less disruptive behavior in females with ADHD may contribute to referral bias causing under
    identification and lack of treatment for females with ADHD
27
Q

What is the estimated prevalence of clinician-assessed adult ADHD?

A

4.4% (4/100)

28
Q

What is the comorbidity of adult ADHD?

A

significantly comorbid w/ wide range of other psychiatric disorders (increased issues w/ psychosocial develop’t)

-mood disorders, anxiety disorders, substance disorders, intermittent explosive disorder

29
Q

What is the Tourette’s syndrome triad?

A
  • Tics
  • ADHD (disturbances of attention dont always meet full criteria ADHD)
  • Obsessive compulsive symptoms (OCS)- dont meet full diagnostic criteria of OCD
30
Q

What is Tourette’s syndrome?

A

Neuropsychiatric spectrum disorder! (comorbid w/ ADHD)

-childhood onset of multiple motor and vocal tics lasting >1 year

31
Q

What symptoms are boys and girls more likely to have in Tourette’s syndrome?

A

boys: tics + ADHD
girls: OCD

32
Q

**What is Chronic Tic disorder?

A

prevalence is higher in children w/ ADHD compared w/ controls; confers substantial additional psychiatric and functional burden

-consider this in initial assessment + mgmt of ADHD; address both syxs

33
Q

ADHD + Tic disorder - comorbidity:

A

tic behaviors can be
subtle, may not meet criteria for diagnosis, intermittently in remission, or merely
absent during assessment for ADHD

susceptibility to tics may be missed

34
Q

ADHD + Childhood suicide- comorbidity:

A

Among suicide decedents with known mental health problems childhood
decedents more often experienced ADHD and less often experienced
depression/dysthymia compared with early adolescent decedents

35
Q

If a patient has an information processing dysfunction relating to executive function, what area of the brain would this stem from? What is the deficiency?

A

prefrontal cortex

deficiency of DA + NE

36
Q

The most consistent cross-study and cross-modality data identifying a brain
region as dysfunctional in ADHD has been where?

A

dorsal anterior midcingulate cortex (daMCC)

37
Q

What symptoms must a person have for a diagnosis of ADHD?

A

children: 6+ symptoms of disorder

adults (17+): 5+ symptoms of disorder

38
Q

What symptoms are associated w/ the inattentive type of ADHD?

A

fails to give close attention to details or makes careless mistakes
difficulty sustaining attention
Does not appear to listen
Struggles to follow through on instructions
Has difficulty with organization
Avoids or dislikes tasks requiring a lot of thinking
Loses things
Is easily distracted
Is forgetful in daily activities

39
Q

What symptoms are associated w/ the hyperactive type of ADHD?

A

Fidgets with hands or feet or squirms in chair
Has difficulty remaining seated
Runs about or climbs excessively in children; extreme restlessness in adults
Difficulty engaging in activities quietly
Acts as if driven by a motor; adults will often feel inside like they were driven by
a motor
Talks excessively
Blurts out answers before questions have been completed
Difficulty waiting or taking turns

40
Q

What is the best objective test for ADHD? pros?

A

Test of Variables of Attention: measures reaction times, immediate availability, easy to read

biggest pro: shorter test for young children

41
Q

What is the conners continuous performance test?

A

task-oriented computerized assessment of attention-related problems in individuals 8+ y/o

42
Q

Pediatric guidelines for ADHD in preschool-aged children (4-5 y/o)?

A

prescribe evidence-based parent- and/or teacher-administered behavior therapy = first line treatment

prescribe methylphenidate if behavior therapy does NOT provide significant improvement + child continues to have moderate-severe syxs.

IMPT

43
Q

Pediatric guidelines for ADHD in elementary school-aged children (6-11y/o)?

A

Prescribe FDA approved medications for ADHD

and/or

evidence-based parent

and/or

teacher-administered behavior therapy as treatment for ADHD, although PREFERABLY both
medication and behavior therapy should be used together

IMPT

44
Q

Pediatric guidelines for ADHD in adolescents (12-18 y/o)?

A

Prescribe FDA approved medications for ADHD with the assent
of the adolescent

And may prescribe behavior therapy as treatment for ADHD,
although preferably both medication and behavior
therapy should be used together.

IMPT

45
Q

What are alternatives to stimulants for ADHD?

A

alpha 2 adrenergic agonists - guanfacine + clonidine

-ability to modulate noradrenergic tone in PFC

46
Q

What is the risk of using bupropion for ADHD symptoms?

A

risk of seizure (dont use if have a history)

47
Q

Describe the ADHD med Atomoxetine.

A

inhibits presynaptic norepinephrine reuptake, resulting in
increased synaptic norepinephrine and dopamine

NOT first line

use caution in pts w/ CV risk factors; can produce QTC PROLONGATION

idk if this drug is impt to know- no bold

48
Q

Who can use modafinil?

A

ADULTS ONLY - improves core symptoms of ADHD; binds DA transporter, inhibit DA reuptake

-assoc. w/ serious dermatologic + psychiatric conditions

49
Q

Describe the ADHD med Methylphenidate.

A

Effectively reduces symptoms of inattention, hyperactivity, and
impulsivity in up to 80% of children with ADHD

MOA: increases DA levels in brain by blocking DA transporters

many children are being exposed to this drug

50
Q

What are the motor disorders?

A

developmental coordination disorder
stereotypic movement disorder
tic disorders

51
Q

What is developmental coordination disorder?

A

The acquisition and execution of coordinated motor skills is
substantially below that expected given the individual’s chronological
age and opportunity for skill learning and use

CLUMSY

(also interfere w/ activities of daily living; early development period; syxs not better explained by any other condition or substance)

52
Q

What is stereotypic movement disorder?

A

Repetitive, seemingly driven, and apparently purposeless motor behavior
(e.g., hand shaking or waving, body rocking, head banging, self-biting, hitting
own body).

(also interfere w/ activities of daily living; early development period; syxs not better explained by any other condition or substance)

53
Q

What do you need to specify w/ stereotypic movement disorder (might be fyi)?

A

Specify if:
With self-injurious behavior, Without self-injurious behavior, Associated with a known medical or genetic condition, neurodevelopmental disorder, or environmental factor

Specify current severity:
Mild: Symptoms are easily suppressed by sensory stimulus or distraction.
Moderate: Symptoms require explicit protective measures and behavioral
modification.
Severe: Continuous monitoring and protective measures are required to
prevent serious injury.

54
Q

What is a tic?

A

a sudden, rapid, recurrent, nonrhythmic motor

movement or vocalization

55
Q

What is the criteria for Tourette’s disorder?

A

Both multiple motor tics and one or more phonic tics must be present at some time during the illness, although not necessarily concurrently

Tics must occur many times a day, nearly every day, or intermittently throughout a period of more than one year

Anatomical location, number, frequency, type, complexity, or severity of tics MUST CHANGE OVER TIME (waxes + wanes**)

Onset of tics before the age of 21 years (the DSM-5 criteria require onset of tics before age 18 years)

Involuntary movements and noises must not be explained by another medical condition (or by the physiological effects of substances as per the DSM-5)

Motor tics, phonic tics, or both must be witnessed by a reliable examiner at some point during the illness or be recorded by videotape or cinematography

56
Q

What is the comorbidity of Tourette’s disorder w/ ADHD?

A

ADHD affects 30-60% of pts w/ TS

ADHD syx often emerge 2-3 yrs BEFORE onset of tics

this comorbidity is associated w/ difficulties in planning, working memory, visual attention, learning, and school performance, and w/ diminished functional ability

57
Q

What is the comorbidity of Tourette’s disorder w/ OCD?

A

OCD affects 10-50% of pts w/ TS

syxs typically emerge a few yrs AFTER onset of tics and often become more severe over time

58
Q

What is the comorbidity of Tourette’s disorder w/ Anxiety disorder?

A

lifetime prevalence of anxiety disorders is 30% in TS pts

59
Q

What is the comorbidity of Tourette’s disorder w/ mood disorder/suicide risk?

A

increased risk of mood disorders; 30% lifetime prevalence

60
Q

What are other comorbidities associated with Tourettes disorder?

A

disruptive behaviors, learning disabilities + poor school performance, sleep disorders (1/2 have sleep complaints)

61
Q

What are some meds used for Tourettes disorders?

A

antidopaminergic drugs (haloperidol, pimozide, aripiprazole), dopamine depleters (inhibit VMAT), antipsychotics, alpha adrenergic agonists, botulinum toxin injection, anticonvulsants

62
Q

What is persistent (chronic) motor or vocal tic disorder criteria?

A

A. single or multiple motor or vocal tics have been present during the illness, but NOT BOTH MOTOR AND VOCAL
B. The tics may wax and wane in frequency but have persisted for > 1 year since first tic onset
C. Onset is < 18 y/o
D. The disturbance is not attributable to the physiological effects of a substance (e.g., cocaine) or another medical condition (e.g.,Huntington’s disease, postviral encephalitis).
E. Criteria have NEVER BEEN MET for Tourette’s disorder.

  • more persistent and chronic*
  • specify if w/ motor ticks only or vocal tics only