Clinical Flashcards

1
Q

What is blepharitis?

symptoms and mangement

A

Inflammation of the eyelid margin due to infection or excessive secretions. Without adequate tear lipid layer, tears evaporate, leading to dry eyes.

Symptoms: burning, gritty eyes.

Signs: crusted eyelids, red eyelid margins, scales at base of eyelashes. History of seborrhoeic dermatitis.

Management:

  1. Eyelid hygiene advice:
    - to soften waxy, oily secretions: steam bathing (10-15mins), warm compresses, cleaning with cool boiled water (& baby shampoo) on cotton bud (side to side motion), avoid rubbing inner surface of lid.
  2. Lubricants.
  3. Topical chloramphenicol.
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2
Q

What is chalazion?

symptoms and mangement

A

Blocked meibomian gland (accumulation of secretions causes inflammation of the eyelid > cyst) > chronic chalazions will become granulomatous.

Symptoms: dry eyes, uncomfortable lump in eyelid. Signs: Hard lump/s in eyelid (red in acute phase). History of blepharitis or acne roasacea. *Recurrent chalazia may suggest neoplasm: biopsy indicated.

Management:

  1. Eyelid hygiene advice: warm compresses
  2. Omega 3 and Flax seeds recommended
  3. Topical antibiotics
  4. Surgical excision (when swelling down, left with small lump – excision).
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3
Q

What is entropion?

symptoms and mangement

A

Inversion of eyelids (eyelashes irritate cornea)

Symptoms: gradual onset red eye, watering, foreign body sensation. Signs: Inverted eyelids, corneal lesions, scarred conjunctiva. History of eyelid surgery or severe conjunctivitis.

Management: surgical correction (can be taped down in short term) + provide lubricant to protect cornea

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4
Q

What is ectropion?

symptoms and mangement

A

Eversion of the eyelids (> loss of tears)

Symptoms: irritable red eye, watering. (tears not able to drain through normal route). Signs: droopy lower lid, eyelid masses causing distortion of anatomy. History: old age (age-related ectropion), eyelid surgery, CN VII palsy (facial). *Biopsy any masses.

Management: surgical reconstruction

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5
Q

What is BCC?

symptoms and mangement

A

Most common eyelid neoplasm. Slow growing, metastases rare.

Symptoms: often none (may present due to cosmetic concern). Signs: ‘rodent ulcer’, typically raised pearly edge and central telangiectasia.

Management: cryotherapy for small lesions, excision and reconstruction if large.

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6
Q

What are different refractive errors?

A

Emmetropia: no refractive error, light is focused on retina.

Astigmatism: Worldwide most common refractive error. Eyeball is rugby ball / egg shaped, light focused in more than one place  blurred vision (headaches, eye strain). Usually accompanied by myopia or hyperopia and can cause amblyopia.

Myopia: Short-sighted: light is focused in front of the retina. Causes: eye too long (axial length) for cornea or cornea too curved / steep. Corrected by a concave lens

Hyperopia: Long-sighted: light is focused behind the retina. Causes: eye too short or cornea too flat. Note: emmetropisation (long sighted at birth, allows eye to grow longer). Corrected by a convex lens.

Presbyopia: Lens hardens with age (approximately age 45): less able to accommodate - typically require reading glasses for near vision.

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7
Q

What is dry eyes?

symptoms / management

A

Reduced tear production (e.g. age-related decline, Sjogren’s syndrome) or increased tear loss (commonly due to blepharitis: increases tear evaporation as the lipid component of tear film usually prevents this evaporation)

Symptoms: irritable, itchy, red eyes.

Signs: Shorter tear break-up time (≤5s) when eye viewed with fluorescein staining (faster evaporation).

May also see irritated regions on cornea (punctate erosions) due to dry areas using fluorescein.

Patient can have watery eyes due to reflex tear production (tear production seems excessive but actually dry eye!). History of known blepharitis, dry mouth.

Management: Lubricants and artificial tears.

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8
Q

What is a subconjunctival haemorrhage?

symptoms / management?

A

Blood vessel leak, normal conjunctival vessels obscured. Usually idiopathic but may be precipitated by sneeze, cough or conjunctivitis.

Usually asymptomatic, may be some foreign body sensation.

Signs: Superficial bleed with mobile vessels, does not affect cornea. General redness, can’t see individual vessels. History of exertion, trauma, anticoagulants, bleeding disorders, hypertension. Possible mild popping sensation prior to redness, or mild ache.

Management: Self-limiting. If trauma is cause consider ophthalmology referral to ensure no underlying scleral damage / injury. Check blood pressure + coagulation status (INR) for legal reasons. Symptomatic treatment e.g. lubricant drops.

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9
Q

What is conjunctivitis?

Most common causes?

A

Inflammation of conjunctiva: infectious, allergy, or chemical injury.

Bacterial: mostly staphylococci, streptococci and especially in children H. influenza.

Viral: adenovirus (2 week healing time as opposed to 1) or herpes simplex (keratoconjunctivitis).

Chlamydial: chlamydia trachomatis serotypes DEFGHIJK.

Allergic
Seasonal = spring + summer, perennial = all year (may fluctuate).

Atopic keratoconjunctivitis: chronic + more severe, begins late teenage years, associated with atopic dermatitis

Vernal keratoconjunctivitis: chronic + more severe, affects boys in 1st decade - itching, photophobia, burning, and tearing. The most common signs are giant papillae, superficial keratitis, and conjunctival hyperaemia

Chemical

  1. Acute presentation e.g. acid or alkali injury.
  2. Chronic presentation = allergic conjunctivitis – drops are common cause.
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10
Q

Symptoms / management of BACTERIAL conjunctivitis?

A

Redness, sticky discharge, foreign body sensation, blurred vision.

Acute conjunctivitis can be caused by Neisseria Gonorrhoae: profuse discharge + can perforate cornea.

Management: topical antibiotics e.g. chloramphenicol drops for 5-7 days

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11
Q

Symptoms / management of VIRAL conjunctivitis?

A

Inflammation typically more acute (more severe): red, watery, light sensitive. Associated features: lid oedema, pre-auricular lymphadenopathy, follicles, keratitis.

Management: supportive measures e.g. lubricant, prophylactic antibiotic drops. If corneal involvement > steroid drops.

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12
Q

Symptoms / management of chlamydial conjunctivitis?

A

Symptoms/signs: Clinical picture between bacterial and viral: more sticky discharge than bacterial, mucopurulent discharge, corneal involvement, follicles present. History of GUM symptoms (e.g. urethritis / cervicitis, unprotected sexual activity).

Ix: Conjunctival swab for PCR.

Management = systemic: oral azithromycin or doxycycline. Refer to GUM.

Serotypes A, B + C cause trachoma (roughening inner surface of eyelids > pain & breakdown of cornea > eventual blindness. If untreated, repeated trachoma infections can cause permanent blindness where eyelids turn inwards).

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13
Q

Symptoms / management of allergic conjunctivitis?

A

Symptoms & signs: Redness, itchiness, mucous discharge, light sensitivity. Conjunctival oedema (chemosis) & papillae.

Management: lubricants, anti-histamines, mast cell stabilisers, steroids in acute exacerbations or severe cases. Very good prognosis in vast majority but corneal complications in severe cases.

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14
Q

Symptoms / management of chemical (acute) conjunctivitis?

A

Symptoms & signs: acute redness, pain, watering, conjunctival / corneal epithelium and stroma trauma and necrosis. Abrasion, stromal inflammation, endothelial loss, limbal stem cell deficiency.

Management: Irrigation with saline until pH 7-7.2.

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15
Q

What is episcleritis?

Management?

A

Inflammation of the episclera (immediately below conjunctiva). Relatively common.

Acute onset of mild discomfort / gritty eyes – recurrent episodes. Mobile hyperaemic vessels (may have spider vessels).

Management: self-limiting; lubricants for comfort.

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16
Q

What is corneal abrasion?

mgmt

A

Corneal epithelial defect. Usually secondary to injury, can also occur secondary to corneal dystrophy (e.g. finger map dot).

Redness, watering, pain (also foreign body sensation, photophobia, blurred vision).

Reduced visual acuity, conjunctival redness, fluorescein stain uptake in areas of broken epithelium, foreign body hidden under eyelid, ‘rust ring’ on cornea.

If deep injury i.e. stroma affected then vision affected.

History: contact lens use, foreign body exposure, trauma, high-risk occupation (e.g. metal working).

Management: Topical antibiotics such as chloramphenicol 1% ointment for 5-7 days (aim to prevent infection). Settles in 2-3 days.

17
Q

What are corneal ulcers?

A

Hypersensitivity ulcers (marginal) or infection (bacterial, viral, fungal, acanthamoeba, herpetic).

Hypersensitivity (marginal) ulcers = Keratitis

Bacterial Ulcers: SIGHT THREATENING condition.

Fungal + acanthamoeba keratitis

Herpetic keratitis

18
Q

Hypersensitivity corneal ulcers?

Symptoms / mgmt

A

Mild symptoms + redness, photophobia, foreign body sensation, mildly reduced vision. Often associated with lid inflammation (blepharitis): Staph aureus cell wall antigens.

Management: Abx + steroid drops: approximately 2 weeks.

19
Q

Bacterial corneal ulcers?

Symptoms / mgmt

A

Increasing pain, redness, blurred vision as infection advances.

Risk factors: contact lens, trauma, poor ocular surface.

Management: Intensive broad spectrum antibiotics e.g. ofloxacin (broad spectrum, covers pseudomonas which is most common contact lens bacteria). Hospitalisation + surgery may be required.

20
Q

Fungal & acanthamoeba keratitis?

Symptoms / mgmt

A

Poorer prognosis.

Usually more severe than bacterial ulcers. Flush.

Similar risk factors + history, but less acute.

Hospitalisation + surgery often required as can progress to perforation.

21
Q

Herpetic keratitis?

Symptoms / mgmt

A

Redness, light sensitivity, gritty sensation, reduced vision. Usually affects epithelium.

Often history of cold sores (not always). Not really painful but light sensitivity. Can cause corneal scarring and if central will affect vision.

Ulcer has classical dendritic shape on fluorescein staining.

Management: Acyclovir. Can be recurrent and need long term prophylactic oral acyclovir (reduces risk by 50%).

22
Q

What is uveitis?

Causes?

A

Inflammation of the pigmented eye structures (ciliary body, iris, choroid).

Note: anterior uveitis = iritis.

Majority are associated with systemic inflammatory conditions (HLA-B27) or infectious conditions

  • Seronegative arthropathies: ankylosing spondylitis, reactive arthritis, psoriatic arthritis
  • Inflammatory bowel disease
  • Juvenile idiopathic arthritis
  • Reiter syndrome
  • Sarcoidosis
  • Bechets disease
  • Syphilis
  • Toxoplasmosis
23
Q

Symptoms of uveitis?

A

Redness, watering, photophobia, blurred vision / visual loss, pain. History of previous episodes.

Conjunctival injection (redness around cornea), hypopyon (white blood cell collection behind cornea) miosis (spasm of pupillary sphincter muscle), posterior synechiae (adhesions cause abnormal attachment of iris to lens > misshapen pupil).

May see keratic precipitates (white inflammatory cells form clumps on endothelium of cornea). Ciliary flush (circumcorneal injection) = ring of red / violet spreading out from cornea > caused by arborisation and engorgement of vessels at junction between cornea + sclera – suggests iris/ciliary body involvement i.e. anterior uveitis). If no past medical history perform full systems review.

24
Q

What are the main eyelid problems?

A

blepharitis: inflammation of the eyelid margins typically leading to a red eye

Stye: infection of the glands of the eyelids

Chalazion (Meibomian cyst) - presents as a firm painless lump in the eyelid. majority resolve spontaneously but some require surgical drainage

entropion: in-turning of the eyelids
ectropion: out-turning of the eyelids

25
Q

What is a stye?

A

Different types:

External (hordeolum externum) - infection (usually staphylococcal) of the glands of Zeis (sebum producing) or glands of Moll (sweat glands).

Internal (hordeolum internum): infection of the Meibomian glands. May leave a residual chalazion (Meibomian cyst)

Management includes hot compresses and analgesia. CKS only recommend topical antibiotics if there is an associated conjunctivitis.

26
Q

What is glaucoma?

A

Optic neuropathies associated with raised intraocular pressure (IOP).

Classified based on whether the peripheral iris is covering the trabecular meshwork, which is important in the drainage of aqueous humour from the anterior chamber of the eye.

Open-angle glaucoma: iris is clear of the meshwork, trabecular network functionally offers increased resistance to aqueous outflow, causing increased IOP - now recognised that a minority of patients with raised IOP do not have glaucoma and vice versa.

Affects 0.5% >40s, prevalence increases with age up to 10% >80 years. males = females.

Primary open-angle glaucoma (POAG, also referred to as chronic simple glaucoma) is present in around 2% of >40.

Other than age, risk factors include:
genetics: first degree relatives of an open-angle glaucoma patient have a 16% chance of developing the disease
black patients
myopia
hypertension
diabetes mellitus
corticosteroids

POAG may present insidiously and for this reason is often detected during routine optometry appointments. Features may include
peripheral visual field loss - nasal scotomas progressing to ‘tunnel vision’
decreased visual acuity
optic disc cupping

Fundoscopy signs of primary open-angle glaucoma (POAG):

  1. Optic disc cupping - cup-to-disc ratio >0.7 (normal = 0.4-0.7), occurs as loss of disc substance makes optic cup widen and deepen
  2. Optic disc pallor - indicating optic atrophy
  3. Bayonetting of vessels - vessels have breaks as they disappear into the deep cup and re-appear at the base
  4. Additional features - Cup notching (usually inferior where vessels enter disc), Disc haemorrhages

Diagnosis:
Case finding and provisional diagnosis is done by an optometrist
Referral to the ophthalmologist is done via the GP
Final diagnosis is done by investigations as below

Investigations:
automated perimetry to assess visual field
slit lamp examination with pupil dilatation to assess optic neve and fundus for a baseline
applanation tonometry to measure IOP
central corneal thickness measurement
gonioscopy to assess peripheral anterior chamber configuration and depth
Assess risk of future visual impairment, using risk factors such as IOP, central corneal thickness (CCT), family history, life expectancy

27
Q

Uveitis managmt?

Complications?

A

Management: Steroid drops (reduce inflammation).

Mydiatics: dilate pupil for comfort (helps with photosensitivity, and helps with pain as movement of pupil /spasm is uncomfortable). If more serious inflammation need to find underlying cause: most common is ankylosing spondylitis (HLA2B7) note: NOT associated with RA!

*All postoperative red eye should be treated as an emergency: complications include endopthalmitis, raised IOP, corneal graft rejection, abrasion, leak from wound. Refer to eye unit / casualty.

28
Q

What is strabismus?

A

Mal-alignment of eyes (i.e. a squint) which can lead to permanently impaired vision (amblyopia i.e. lazy eye where vision doesn’t develop normally despite glasses etc) in children.

Can be paralytic or non-paralytic

29
Q

What is amblyopia?

A

In children to prevent double vision when eyes are not aligned, brain ‘shuts down’ one eye and other eye becomes dominant. ‘Shut-down’ eye is under-stimulated vision fails to develop correctly, if not corrected by age 7-8 under-stimulated eye said to be amblyopic - permanent visual impairment of that eye. Can be prevented by temporary patching to force use of other eye.

30
Q

What is paralytic strabismus

A

angle between eyes changes depending on direction of gaze - CN palsies or extraocular muscle damage - causes double vision and affects older adults

diabetes, thyroid disorders and brain anuerysm risk factors all predisposing

treat underlying cause

31
Q

What is non-paralytic strabismus

A

angle between eyes remains same regardless of direction of gaze, idiopathic affects children

may have poor vision / abnormal head posture
positive family history

Exam: positive cover-uncover test (idenitifes the type of strabismus) , white pupil (corneal light reflex test)

refer to orthoptics for corrective equipment e.g. prisms

may require surgery