Clindamycin Flashcards

1
Q

Clindamycin is a

A

lincosamide antibiotic; chlorine-substituted derivative of lincomycin

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2
Q

Clindamycin is bactericidal/bacteriostatic

A

bacteriostatic

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3
Q

Clindamycin MOA

A

inhibits protein synthesis by binding reversibly to 50S ribosomal subunits of susceptible bacteria
inhibits peptide formation and interferes with translocations step

binds near site where macrolides bind

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4
Q

Clindamycin spectrum coverage

A

dark purple: prevotella

light purple: streptococcus, s. pneumoniae, viridans, MSSA, MRSA

dark red: fusobacterium

light red: bacteroides, clostridium

Other: pneumocystic jirovecii, protozoa

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5
Q

Clindamycin resistance mechanisms

A

mutation of bacterial ribosomal RNA

alterations in 50S ribosomal proteins at receptor site

enzymatic inactivation

modification of 23S ribosomal unit of 50S receptor by methylation of adenine (erm)

inducible resistance occurs during therapy

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6
Q

Macrolide and Lincosamide resistance

A

methylation of the ribosomal target which leads to cross-resistance to macrolides, lincosamides, and streptogramin B

MLSB phenotype which can be constitutive or inducible

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7
Q

Macrolide and Lincosamide resistance is mediated by

A

plasmids

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8
Q

Efflux by ERY

A

msrA (low level)

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9
Q

ribosome alteration (ERY, CLI)

A

Erm (high level)

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10
Q

Drug inactivation (CLI)

A

inuA (rare)

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11
Q

D-test positive is when

A

erythromycin causes clindamycin ring to look like a D

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12
Q

msrA

ERY:
CLI:

A

E: R
C: S

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13
Q

erm

ERY:
CLI:

A

E: R
C: S inducible

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14
Q

erm

ERY:
CLI:

A

E: R
C: R constitutive

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15
Q

both negative

ERY:
CLI:

A

E: S
C: S

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16
Q

Clindamycin absorption

A

nearly completely absorbed after oral administrayion

17
Q

Clindamycin can be given

A

IV/IM or PO

18
Q

Clindamycin tissue penetration

A

readily distributed into most fluids and tissues EXCEPT CSF

penetrates well into abbesses and phagocytic cells
high levels in bones
crosses placenta

19
Q

Clindamycin elimination

A

metabolized by liver so accumulation may occur in severe hepatic failure, may require dose adjustment

20
Q

Antimicrobial activity persists in feces for

A

> 5 days after IV is stopped

21
Q

Clindamycin 1/2 life

A

2.5 hours, short

22
Q

Clindamycin should/should not be renally adjusted

A

should not

23
Q

In severe hepatic disease, monitor

A

liver enzymes during therapy

24
Q

Clindamycin indications

A

skin and soft tissue infections caused by strep and staph

  • CA MRSA
  • inhibits bacterial toxin synthesis (role in necrotizing infections)

respiratory tract infections

other anaerobic infections

  • female genital tract
  • prophylaxis of endocarditis in patients with valvular disease undergoing certain dental procedures

with primaquine used as alternative for pneumocystis jirovecci pneumonia

with pyrimethamine for AIDS related toxoplasma encephalitis

topical clindamycin for acne and bacterial vaginosis

anaerobic infections (tooth abscesses)

surgical prophylaxis

antibiotic prophylaxis for GBS in penicillin allergic

25
Q

Clindamycin adverse effects

A

GI: nausea, vomiting, diarrhea, mostly with PO
skin rash
impaired liver function
neutropenia
C. diff infections
may potentiate effect of neuromuscular blockers if administer concurrently

26
Q

Clindamycin drug interactions

A

may block neuromuscular transmission and enhance the action of other blocking agents

27
Q

Clindamycin use during pregnancy

A

inconclusive or inadequate evidence in pregnant, WHO recommends avoiding while breast feeding