Clin Sci Flashcards

1
Q

Which is the most important microsomal enzyme in drug metabolism?

A

Cytochrome P450

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Classic example of therapeutic failure because liver enzyme induction decreases duration of a drug?

A

OCP when also using rifampicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which drugs induce liver enzymes

A

Phenobarbitone
Rifampicin
Alcohol - excess
Phenytoin
St John’s Wort
Carbazepine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which drugs inhibit cytochrome P450?

A

Chloramphenicol
Erythromycin
Sulfonamides
Ketoconazole
Isoniazid
Cimetidine
Ciprofloxacin
Ethanol
Allopurinol
Omeprazole
Disulfiram
Sodium valproate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly