Clin: Clinical Serology and Lab Testing in Rheumatic Disease Flashcards

1
Q

ESR is a good marker for monitoring disease activity, especially in what 2 conditions?

A

Polymyalgia rheumatica and Giant Cell arteritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Between ESR and CRP, which rises and falls quicker?

A

CRP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

A CRP >____ mg/L is inflammatory

A

>8 mg/L

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

In which type of RA will rheumatoid factor (RF) be present 100% of the time?

A

“Nodular” RA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Rheumatoid Factor (RF) can positive in which conditions?

A
  • Healthy pt’s and pt’s >60 y/o
  • Sjogrens syndrome and SLE
  • Sarcoidosis, malignancy, and lung disease
  • Cryoglobulinemia
  • Primary biliary cirrhosis
  • Mixed CT diseases
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How does the the levels of Rheumatoid Factor (RF) correlate with a disease process?

A

High levels associated with aggressive dz, joint erosions, and worse prognosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which markers, if positive, have a 99.5% specificity for RA?

A

Anti-CCP + RF (+)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Anti-DS DNA antibody is seen in 50% of what?

A

SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are 4 hematologic (CBC) indicators of SLE?

A
  • Hemolytic anemia w/ reitculocytosis

or

  • Leukopenia (<4000/mm3 total)

or

  • Lymphopenia (<1500/mm3 total) on 2+ occasions

or

  • Thrombocytopenia (<100,000/mm3)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which imaging modality is sensitive for soft tissue abnormalities (synovitis, tendonitis, bursitis) and erosions; can also be used to aid in injecting/aspirating a joint?

A

Ultrasonography

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which imaging modality is most sensitive for detecting bone erosions?

A

CT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which imaging modalty is the best for bony abnormalities (trabecular, cortical bone), erosions, fractures, degenerative or inflammatory arthritis?

A

CT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is MRI good for and what is one of the cons to using it?

A
  • Useful for soft tissue abnormalities
  • Good for spine, SI, synovitis, tenosynovitis, erosions, joint inflammation
  • Gadolinium contrast taken up in inflammed synovium –> can cause nephrogenic systemic fibrosis in pt’s with kidney disease
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are 2 arthritic complications associated with Diabetes?

A
  • Charcot’s
  • Cheiroarthropathy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly