Classifications

Question 1

Factors predisposing to autoimmunity

Answer 1

1. Genetic factors
   Marked familial incidence ie hla gene
   Eg. HLA DR4- rheumatoid arthritis
   Hla b27- ankylosing spondilytis
2. Hormonal factors- 90% occurs in women.
   Oestrogen may activate autoreactive b cells that produce auto antibodies
3. Env factors: bacteria like
   strep pyogens- rheumatic fever
   Campylobacter -guillian barre
   Borelia- lyme disease

Virus
hep b virus -multiple sclerosis
Hep c- mixed cryoglobinemia
Coxackie virus b 4- DM
“””””” B3 -myocarditis

Drugs procainamide predisposes SLE

Age increases with age

Question 3

Mechanism of autoimmunity

Answer 3

Molecular mimicry
Alteration of self antigen
Release of sequestered ag
Epitope spreading
Failure of reg t cell

Question 4

Classify autoimmunity

Answer 4

1. Organ specific autoimmune disease
2. Non organ specific autoimmune disease

Question 5

Organ specific aid

Answer 5

1.Allergic encephalitis
2.Chronic thyroiditis
3.Insulin dependent diabetes mellitus
4.Myasthenia gravis
5.Autoimmune haemolytic anaemia thrombocytopenia granulocytopenia
6.Guillian barre syndrome
7.Pemphigus
8.Iga nephropathy

Question 6

Non organ specific

Answer 6

SLE
RHEUMATOID ARTHRITIS
RHEUMATIC FEVER
REITERS SYND
GOOD PASTEUR SYND
WEGNERS GRANULAMATOSIS