Classic Labs/Findings

Question 1

Anticentromere antibodies

Answer 1

Scleroderma (CREST)

Question 2

Antidesmoglein (epithelial) antibodies

Answer 2

Pemphigus vulgaris (blistering)

Question 3

Anti-glomerular basement membrane antibodies

Answer 3

Goodpasture’s syndrome (glomerulonephritis and hemoptysis)

Question 4

Antihistone antibodies

Answer 4

Drug-induced SLE (hydrazine, isoniazid, phenytoin, procainamide)

Question 5

Anti-IgG antibodies

Answer 5

Rheumatoid arthritis (systemic inflammation, joint pannus, boutonnière deformity)

Question 6

Antimitochondrial antibodies (AMAs)

Answer 6

Primary biliary cirrhosis (female, cholestasis, portal hypertension)

Question 7

Antineutrophil cytoplasmic antibodies (ANCAs)

Answer 7

Vasculitis (c-ANCA: granulomatosis with polyangiitis [Wegner’s]; p-ANCA: microscopic polyangiitis, Churg-Strauss syndrome)

Question 8

Antinuclear antibodies (ANAs: anti-Smith, anti-dsDNA)

Answer 8

SLE (type III hypersensitivity)

Question 9

Antiplatelet antibodies

Answer 9

Idiopathic thrombocytopenic purpura

Question 10

Anti-topoisomerase antibodies

Answer 10

Diffuse systemic scleroderma

Question 11

Anti-transglutaminase/anti-gliadin/anti-endomysial antibodies

Answer 11

Celiac disease (diarrhea, distention, weight loss)

Question 12

“Apple core” lesion on abdominal x-ray

Answer 12

Colorectal cancer (usually left-sided)

Question 13

Azurophilic peroxidase-positive granular inclusions in granulocytes and myeloblasts

Answer 13

Auer rods (acute myelogenous leukemia, especially the promyelocytic [M3] type)

Question 14

Bacitracin response

Answer 14

Sensitive: Streptococcus pyogenes (group A); Resistant: S. agalactiae (group B)

Question 15

“Bamboo spine” on x-ray

Answer 15

Ankylosing spondylitis (chronic inflammatory arthritis: HLA-B27)