Class side effects

Question 1

Penicillins

Answer 1

Hypersensitivity reactions

Question 2

Tetracyclines

Answer 2

Photosensitivity
Tooth discoloration
CI in pregnancy and children < 8 years

Question 3

Fluoroquinolones

Answer 3

QT prolongation
Tendon damage/rupture

Question 4

Macrolides

Answer 4

QT prolongation

Question 5

Warfarin

Answer 5

Bleeding
CI in pregnancy

Question 6

Corticosteroids

Answer 6

Weight gain
Increased infection risk
Hyperglycemia
Osteoporosis

Question 7

Beta-2 agonists

Answer 7

Tachycardia
Palpitations
Anxiety
Tremor

Question 8

Beta-blockers

Answer 8

Hyper/hypoglycemia
Rebound hypertension
Impotence in men

Question 9

Calcium channel blockers

Answer 9

DHP = decrease SVR
Non-DHP = decrease cardiac output
Gingival hyperplasia
Flushing
Palpitations
Constipation (more with verapamil)

Question 10

Nitrates

Answer 10

Hypotension
Headache
Flushing
Dizziness
CI with PDE5i + riociguat

Question 11

PDE-5 inhibitors

Answer 11

Hypotension
Headache
Flushing
Nasal congestion

Question 12

Benzodiazepines

Answer 12

Drowsiness
Sedation
Dependence

Question 13

Aspirin

Answer 13

Reye syndrome (children)
Tinnitus
Bronchospasm
GI irritation/bleeding risk

Question 14

Opioids

Answer 14

Constipation
Nausea
Dizziness
Respiratory depression
Miosis (opioid high eyes)

Question 15

PPI

Answer 15

Hypomagnesemia
Headache
GI disturbances
Long-term = osteoporosis, C diff risk, fractures

Question 16

Prostaglandin eye drops

Answer 16

Blurred vision
Stinging
Conjunctival reddening

Question 17

Metronidazole

Answer 17

GI upset
Hypersensitivity reactions
Taste disturbances

Question 18

Metformin

Answer 18

Lactic acidosis
GI upset
Metallic taste

Question 19

Methotrexate

Answer 19

Mouth ulcers (stomatitis)
Bone marrow suppression
Pulmonary fibrosis

Question 20

Allopurinol

Answer 20

Skin rash - test for HLA B 5801 allele (if positive don’t give)
Nausea/diarrhea
Increased LFT’s

Question 21

SSRI antidepressants

Answer 21

GI upset
Sexual dysfunction
Weight disturbances
Increased bleeding risk
Serotonin syndrome
Suicidal ideation

Question 22

ACE inhibitors

Answer 22

Hyperkalemia
Cough
Hypotension

Question 23

Spironolactone (non-selective aldosterone antagonist)

Answer 23

Hyperkalemia
Gynecomastia

Question 24

Loop diuretics

Answer 24

Hypotension
Dehydration
Electrolyte disturbances (decreased sodium, magnesium, potassium, calcium, chloride)
Hearing loss
Increased risk of gout

Question 25

Antipsychotics

Answer 25

Extrapyramidal effects (more with FGA) Sedation Weight gain Lipid abnormalities Increased risk of diabetes QT interval prolongation Sexual dysfunction Agranulocytosis (particularly clozapine)

Question 26

Carbamazepine

Answer 26

GI upset Dizziness Ataxia Hyponatremia

Question 27

Clopidogrel

Answer 27

Bleeding risk GI upset Thrombocytopenia

Question 28

H2RA

Answer 28

Headache Bowel disturbances Dizziness

Question 29

H1 receptor antagonists

Answer 29

Sedation Dizziness GI upset

Question 30

Insulin

Answer 30

Hypoglycemia

Question 31

Laxatives

Answer 31

Abdominal pain/cramps Diarrhea Flatulence

Question 32

Nitrofurantoin

Answer 32

Brown urine GI upset Hypersensitivity reactions Peripheral neuropathy

Question 33

Phenazopyridine (Azo, Pyridium)

Answer 33

Orange urine

Question 34

NSAIDs

Answer 34

Bleeding risk CV risk Hypersensitivity reactions Fluid retention

Question 35

Estrogens

Answer 35

VTE Increased risk of cancer

Question 36

Phenytoin

Answer 36

Gingival hyperplasia Nystagmus Hematological disorders Hair growth Hypersensitivity reactions