Class Review Flashcards
Which of the following statements is TRUE?
a. The liver has low blood flow and high vascular resistance
b. The liver has low blood flow and low vascular resistance
c. The liver has high blood flow and high vascular resistance
d. The liver has high blood flow and low vascular resistance
d. The liver has high blood flow and low vascular resistance
Which of the following would NOT be a function of the liver?
a. Gluconeogenesis
b. Formation of urea
c. Synthesis of prothrombin
d. Synthesis of calbindin
d. synthesis of calbindin
Which of the following is NOT characteristic of the metabolic syndrome associated with diabetes?
a. Peripheral neuropathy
b. Obesity
c. Fasting hyperglycemia
d. Hypertension
a. peripheral neuropathy
Hemoglobinascite is released from damaged RBCs and split into globin and heme by macrophages. Heme is then converted into which of the following by heme oxygenase?
a. Cholic acid
b. Biliverdin
c. Bilirubin
d. Urobilinogen
b. biliverdin
A higher than normal back pressure in hepatic veins may lead to the following condition?
a. Jaundice
b. Cirrhosis
c. Ascites
d. Diabetes
c. ascites
Which of the following BEST represents the most important function of insulin in the body?
a. Activates phosphorylase and phosphatase necessary for the uptake of glucose in the liver
b. Controls from the moment to moment whether fat or carbohydrate will be used by cells for energy
c. Activates lipoprotein lipase to split triglycerides into fatty acids
d. Activates the ornithine transport mechanism
b. controls moment to moment whether fat will be used by cells for energy
In the pituitary gland, somatotropes (acidophils) secrete which of the following trophic hormones?
a. Thyroid stimulating hormone
b. Human growth factor
c. Adrenocorticotrophic hormone
d. Luteinizing hormone
b. human growth factor
The hormone response element is best characterized by which of the following?
a. An intracellular protein that binds to a lipid soluble hormone to form the hormone-receptor complex
b. A regulatory sequence of DNA
c. Phosphatidylinositol biphosphate component of a second-messenger system
d. A tyrosine-binding protein for thyroxine
b. a regulatory sequence of DNA
Some signal transduction mechanisms involve calcium. In these pathways a change in membrane potential opens calcium channel. Calcium ions enter the cell and bind to which of the following?
a. Janus kinase
b. The receptor component of a G protein
c. Calmodulin
d. Diacylglycerol
c. calmodulin
Down regulation of receptors may occur as a result of which of the following?
a. Inactivation of some of the intracellular protein signaling molecules
b. Activation of some of the receptor molecules
c. Increased production of receptors
d. Increase in the target cell’s responsiveness to the hormone
a. inactivation of some of the intracellular protein signaling molecules
One of the best-known stimuli for increasing the rate of thyroid releasing hormone secretion is?
a. Cold
b. Anxiety
c. cAMP
d. Excitement
a. cold
Which of the following is a common cause of hyperthyroidism?
a. Hashimoto disease
b. Grave’s disease
c. Endemic goiter
d. Cretinism
b. Graves disease
The basal membranes of thyroid cells contain symporters for iodide. What ion is co-transported w/ iodide by these symporters?
a. Sodium
b. Potassium
c. Chloride
d. Hydrogen
a. sodium
The major hormonal product of the thyroid gland is thyroxine. How many iodinated tyrosine resides are found in thyroxine?
a. One
b. Two
c. Three
d. Four
d. four
Pendrin is used for which of the following functions?
a. As a sodium-iodide symporter in basal membrane of a thyroid follicle cell
b. As a hepatic-derived conjugating protein for the transport of thyroxine in the blood
c. As a chloride-iodide counter-transporter in the apical membrane of a thyroid follicle cell
d. As a decoupling protein used to separate iodide from thyroglobulin during the recycling of thyroxine
c. as a chloride-iodide counter transporter in the apical membrane of a thyroid follicle cell
Osteoclasts do out have receptors for parathyroid hormone; instead they respond to secondary signals from osteocytes which do have the receptors. Which of the following is important as a major secondary signal ligand in this communication process?
a. Osteoprotegerin
b. Pendrin
c. Calmodulin
d. Calbindin
a. osteoprotegerin
Hyperkalemia, mild acidosis, rise in RBC concentration, loss of ability to maintain normal blood glucose concentrations between meals, and changes in pigmentation pattern are all consistent with which of the following conditions?
a. Cushing’s
b. Hypothyroidism
c. Addison’s
d. Hyperthyroidism
c. addisons
Which of the following is/are functions of glucocorticoids?
a. Stimulation of gluconeogenesis
b. Decreased glucose utilization by cells
c. Resists inflammation
d. Resists stress
e. All of the above are functions of glucocorticoids
e. all of the above
Aldosterone is the major mineralocorticoid and is secreted by which of the following regions of the adrenal cortex?
a. Zona glomerulosa
b. Zona fasciculata
c. Zona reticularis
d. Zona medullaris
a. Zona glomerulosa
Cortisol secretion is controlled mainly by which of the following factors?
a. Plasma potassium concentration
b. Angiotensinogen II
c. Plasma sodium concentration
d. ACTH
d. ACTH
Which of the following resists stress, resists inflammation, and stimulates gluconeogenesis but may lead to adrenal diabetes?
a. Aldosterone
b. Cortisol
c. Angiotensin II
d. Pregnenolone
b. cortisol
Which of the following is NOT a characteristic of lack of aldosterone?
a. Reduction in blood volume
b. Hypernatremia
c. Hyperkalemia
d. Reduction in blood pressure
b. Hypernatremia
Adrenal diabetes may occur due to excess of which of the following?
a. Aldosterone
b. Mineralocorticoids
c. Glucocorticoids
d. Androgenic hormones
c. glucocorticoids
Addison’s disease is due to a deficiency of which of the following?
a. Glucocorticoids
b. Mineralocorticoids
c. Androgenic hormones
d. Both A and B
d. both A and B
Which of the following characteristics of Addison’s disease is due to a adrenalcoid deficiency?
a. Muscle weakness
b. Decrease in cardiac output
c. Rise in RBC concentration
d. Mild acidosis
a. muscle weakness
The major glucocorticoid secreted by the adrenal cortex is?
a. Aldosterone
b. Estrogen
c. Cortisol
d. DHEA
c. Cortisol
Spironolactone blocks mineralocorticoid receptors. This would probably have which of the following effects?
a. Hypernatremia
b. Increase in extracellular fluid volume
c. Reduction in cardiac output
d. Anemia
c. reduction in cardiac output
Moon face, “buffalo torso”, hypertension and increased blood glucose are characteristic of which of the following?
a. Addison’s disease
b. Cushing’s disease
c. Cretinism
d. Grave’s disease
b. Cushings disease
The active form of vitamin D promotes the intestinal uptake of calcium by increasing the formation of which of the following substances?
a. Apoprotein B
b. Calbindin
c. Albumin
d. Calciferol
b. Calbindin
Hypocalcemia usually becomes lethal at which of the following levels?
a. 12 mg/dl
b. 9.5 mg/dl
c. 6 mg/dl
d. 4 mg/dl
d. 4 mg/dl
Normally the body takes in about 1000 mg of calcium per day orally. How much of this is lost in the feces per day?
a. 350 mg
b. 750 mg
c. 900 mg
d. 990 mg
c. 900 mg
Parathyroid hormone has which of the following effects on renal tubules?
a. PTH promotes the reabsorption of potassium
b. PTH promotes the reabsorption of calcium
c. PTH promotes the reabsorption of sodium
d. PTH promotes the reabsorption of potassium, calcium, and sodium
b. PTH promotes the reabsorption of calcium
The conversion of 25-hydroxycholecalciferol to 1,25-hydroxycholecalciferol occurs in which of the following?
a. Bone
b. Liver
c. Blood
d. Kidney
d. kidney
Death due to hypoparathyroidism is often due to which of the following effects?
a. Massive loss of calcium from the skeletal system
b. Excessive reabsorption of sodium followed by tetany
c. Laryngeal muscle spasms
d. Vitamin D deficiency
c. laryngeal muscle spasms
Approximately 40% of plasma is bound to plasma proteins and is not filtered by the kidneys. What effect does acidosis have on plasma calcium ion concentration (unbound)?
a. There is an increase in bound calcium and the calcium ion concentrations increases
b. There is a decrease in bound calcium and the calcium ion concentrations decreases
c. There is a decrease in bound calcium and the calcium ion concentrations increases
d. There is an increase in bound calcium and the calcium ion concentrations decreases
c. There is a decrease in bound calcium and the calcium ion concentration increases
Which of the following nerves supplies parasympathetic innervation of the parotid gland?
a. Facial nerve
b. Trigeminal nerve
c. Glossopharyngeal nerve
d. Vagus nerve
c. glossopharyngeal nerve
Which of the following conditions describes the effects of the ANS on sweat glands in the hands and feet?
a. Parasympathetic; cholinergic
b. Parasympathetic; adrenergic
c. Sympathetic; cholingeric
d. Sympathetic; adrenergic
c. Sympathetic, cholinergic
Which of the following acts as an antihypertensive agent by being uptaken by adrenergic neurons and replacing norepinephrine in the synaptic vesicles?
a. Methoxamine
b. Albuterol
c. Guanethidine
d. Phenoxybenzadine
c. Guanethidine
The greater splanchnic nerve originates from the spinal cord levels T5-T9. Which of the following statements concerning this nerve is correct?
a. It is composed of myelinated fibers and synapses in the superior mesenteric ganglion
b. It is composed of postganglionic fibers and terminates within the wall of the gut tube
c. It is composed of myelinated fibers and synapses in the celiac ganglion
d. It is composed of preganglionic fibers and synapses in the superior mesenteric ganglion
c. It is composed of myelinated fibers and synapses in the celiac ganglion
Beta-3 receptors are involved in which of the following functions?
a. Adrenergic, thermogenesis
b. Adrenergic, glycogenolysis
c. Adrenergic, cardiac acceleration
a. adrenergic, thermogenesis