Class III Antiarrhythmics - K Channel Blockers

Question 1

Amiodarone (Class, MOA, Indications, AEs)

Answer 1

[K Channel Blocker] - rhythm control

MOA: Blocks K channel –> inc. QTc w/o inc. heart rate + increases refractoriness

Indications:
- rate control of supraventricular arrhythmias
- VT + VF

AE’s: ALL toxicities

Question 2

Dronedarone (Class, MOA, Indications, CI, AEs)

Answer 2

[K Channel Blocker] - rhythm control

MOA: Blocks K channel –> inc. QTc w/o inc. heart rate + increases refractoriness

Indications: AF + AFL

CI: CHF + CAD

AE’s: N/A

Question 3

Sotalol (Class, MOA, Indications, CI, AEs)

Answer 3

[K Channel Blocker] - rhythm control

MOA: Blocks K channel –> inc. QTc w/o inc. heart rate + increases refractoriness

Indications: AF, supraventricular tachycardia

CI: CHF + asthma/COPD

AE’s: beta blocker effects

*requires inpatient admission

Question 4

Dofetilide (Class, MOA, Indications, AEs)

Answer 4

[K Channel Blocker] - rhythm control

MOA: Blocks K channel –> inc. QTc w/o inc. heart rate + increases refractoriness

Indications: AF, supraventricular tachycardia

CI: CHF + CAD

AE’s: N/A

*requires inpatient admission

Question 5

Ibutilide (Class, MOA, Indications, AEs)

Answer 5

[K Channel Blocker] - rhythm control

MOA: Blocks K channel –> inc. QTc w/o inc. heart rate + increases refractoriness

Indications: AF, supraventricular tachycardia

CI: CHF + CAD

AE’s: N/A