Class 3 - Intravenous Infusions Flashcards
1
Q
What does intravenous infusion allow for?
A
Precise control of plasma drug concentration since drug is administered at a constant rate of input.
2
Q
When is steady-state reached?
A
When rate in = rate out
or
Rate of drug infusion = clearance of the drug
Css = R/Cl = R/kVd
3
Q
Rate of infusion does not change the time it take to get to steady state. T/F
A
True!!!
4
Q
How many half lives does it take to approach 1?
A
5
5
Q
What is the equation to find Cl?
A
Cl = k x Vd
6
Q
What equation do you use to find concentration prior to reaching steady-state?
A
C = R/Cl (1-e^(-kt))
7
Q
What part of the equation represents the fraction of steady state achieved?
A
1-e^(-kt)
8
Q
What equation is used after an continuous infusion that has reached steady state has stopped to find concentration?
A
C = Ce^(-kt)
