CKD pt 1 Flashcards
official definition of CKD
- presence of markers of kidney damage for 3+ months
- Structural or functional abnormalities of the kidney (+/- a current decrease in GFR) that can ultimately lead to decreased GFR
- Manifested by either pathological abnormalities or other markers of kidney damage, including abnormalities in the composition of blood or urine, or abnormalities in imaging tests.
OR - The presence of GFR <60 mL/min/1.73 m2 for 3+ months with or without other signs of kidney damage
what is CKD (short definition)
Spectrum of disorders associated with abnormal kidney function and/or progressive decline in GFR
Decline in function usually _____ even if cause is removed
CKD is due to _____
persists
nephron overwork injury
pathophys of CKD
Kidneys respond to a reduction in the number of functional nephrons by signaling changes that lead to:
1. hyperfiltration
2. hypertrophy
3. RAAS plays a role in these changes
how does hypertrophy change glomerular architecture? result?
Glomerular architecture becomes distorted with hypertrophy, hindering filtering abilities
Inflammation and fibrosis ensue
what is “the renal rebound”
- may see an improvement in markers like BUN, Creatinine, and GFR in some circumstances!
- Recovery from AKI-on-CKD
- Removal of toxic substances
- Diet changes
- Improved hydration
- Control of other disease states
does NOT reflect the restoration of renal tissue, but rather the removal of disease burden on still-functioning nephrons.
Over 70% of cases of late-stage CKD (Stage 5 or ESRD) are due to ?
DM
HTN/vascular disease
Other cases - glomerulonephritis, polycystic kidney disease,
chronic tubulointerstitial disease, etc.
CKD is an independent risk factor for ?
CVD
what type of CKD can ↑ risk of CV mortality
proteinuric CKD
risk factors for CKD
- Patient Demographics
- Older age
- sub-Sarahan African ancestry - Historical Factors
- Previous episode of AKI
- FHx of renal disease
- Smoking
- Lead exposure - GU Conditions
- Structural urinary tract abnormalities
- Proteinuria
- Abnormal urinary sediment - Metabolic Conditions
- DM
- Low HDL
- Obesity
- MetS - Other Conditions
- HTN
- Autoimmune disease
- Cardiorenal Syndrome
Deterioration of one organ results in deterioration of the other
Cardiorenal Syndrome (Renocardiac Syndrome)
types of Cardiorenal Syndrome (Renocardiac Syndrome)
Type 1 (Acute CRS) - AKI caused by acute cardiac disease
Type 2 (Chronic CRS) - CKD caused by chronic cardiac disease
Type 3 (Acute RCS) - Acute cardiac disease caused by AKI
Type 4 (Chronic RCS) - Chronic cardiac decompensation caused by CKD
Type 5 (Secondary CRS) - Simultaneous heart and kidney dysfunction
caused by another acute or chronic systemic disorder
Newer recommendation of staging CKD
GFR and albuminuria
Higher levels of albuminuria =____ mortality risk, ____ CKD progression, _____ risk of ESRD - regardless of GFR
higher
Early CKD
Kidney damage with normal GFR
GFR >90
what staging?
1
Kidney damage with mildly decreased GFR
GFR 60-89
what staging?
2
Mildly to moderately decreased GFR
GFR 45-59
what staging?
3a
Moderately to severely decreased GFR
GFR 30-44
what staging
3b
Severely decreased GFR
GFR 15-29
what staging
4
Kidney failure / ESRD
May add D if treated with dialysis
GFR <15
what staging
5
albumin Normal to mildly increased
AER < 30
what is the staging?
A1
Moderately increased (microalbuminuria)
AER 30-300
what staging?
A2
Severely increased (macroalbuminuria)
May be subdivided into nephrotic and non-nephrotic
AER >300
what staging?
A3
s/s of early-mid CKD
asx
eventual s/s of early-mid CKD
slow onset of nonspecific s/s
MC PE finding of CKD overall
HTN
Present in early CKD, and worsens as CKD progresses
Later stages - volume overload
Late CKD s/s
waste build up - GFR ~10 mL/min/1.73 m2
Leads to S/S of uremia
S/S of uremia warrants admission and dialysis consult
Dialysis normally improves uremic syndrome
what specific sign can be seen in uncontrolled prolonged CKD?
Uremic Frost: crystallized urea excreted in sweat
low serums seen in CKD
Heme - RBC, H&H (normocytic, normochromic anemia)
Lytes/Acid-Base - Ca, Na, pH (Met. acidosis)
Renal - GFR
Others - vitamin D, HDL
high serums seen in CKD
Lytes/Acid-Base - K
Renal - BUN, sCr
Others - phosphate, PTH, triglycerides, uric acid
Broad, waxy casts in UA is seen in what condition?
CKD
what is often present in CKD UA?
proteinuria
glucosuria may be present
stage 1 and 2 CKD s/s
Usually no symptoms from decreased GFR
May see s/s from underlying disease
Edema, HTN
Anemia, fatigue, anorexia
Abnormal calcium, phosphorus, vitamin D, PTH
Abnormal Na, K, water, and acid-base balance
what stage of CKD could they be in?
stage 3 and 4
More likely to have S/S, abnormal labs
All organ systems usually affected by this point
marked disturbance in ADL, well being, nutrition, water and electrolyte homeostasis
uremic syndrome
what stage of CKD
stage 5/ESRD
does an abnormal renal imaging indicate CKD?
Yes!
Abnormal renal imaging can
indicate CKD even if there is
normal Cr/GFR
- Polycystic kidneys
- Small kidneys ( < 9-10 cm )
- Asymmetric kidneys (vascular disease)
main tx goal of CKD
slow progression
1. Control underlying process
2. Reduce intraglomerular HTN - ACE/ARB
3. Reduce proteinuria - ACE/ARB, dietary protein restriction
4. Avoid further injury - Obstruction, nephrotoxins, flare of underlying disease
5. If DM - control glucose (HbA1c <7%) - SGLT-2 inhibitors
6. Adjust medication doses as needed
80% of CKD pts die before needing dialysis, primarily due to ?
CV disease
MC complication of CKD
CV complications of CKD include:
Hypertension (HTN)
Coronary Artery Disease (CAD) / Hyperlipidemia
Heart Failure (HF)
Atrial Fibrillation
Pericarditis
HTN can be Exacerbated by ___ and ____ for CKD
hyperreninemia, exogenous EPO
goal bp for HTN complication of CKD
< 130/80 (or 140/90) mmHg
nonpharm tx for HTN - CKD
diet, exercise, wt loss
Treatment of OSA (if present)
Low sodium diet - 2300 mg/day
pharm tx for HTN - CKD
- ACE inhibitors or ARBs
- Check sCr and K+ in 7-14 d - starting or ↑ dose
- Hyperkalemia or >30% Cr increase - reduce or stop - Diuretics nearly always needed
- Thiazides - early CKD
- Loop - more effective in later CKD (GFR < 30)
- Overdiuresis or low vascular volume → AKI - Other anti-HTN rx - CCBs, BBs
primary finding + other labs of hyperlipidemia - CKD
Hypertriglyceridemia
Total cholesterol concentration - usually normal
Lower HDL and increased lipoprotein (a) also common
what CAD/hyperlipidemia condition is accelerated especially in ESRD?
atherosclerosis
tx for CAD / Hyperlipidemia - CKD
- Lifestyle changes
- Statins - recommended for most patients with CKD due to CV risk
- PSK9 inhibitors and ezetimibe - may be used as adjunct to statin therapy
- Fibrates - increased rhabdomyolysis risk when paired with statins in CKD pts
- Not shown to reduce risk of mortality