CKD - Part 2 - Exam 1 Flashcards
1
Q
What is the difference between nephritic and nephrotic? What is the proteinuria cut off?
A
nephritIc is for INFLAMMATION/IMMUNE and the urine sediment tends to be heavier on the bleeding (hematuria) +/- RBC casts
LESS than 3 grams is nephritic and MORE than 3 grams is nephrotic
Nephrotic: think PROTEIN in the urine, more than 3 grams with “bland” urine sediment
2
Q
“bland” urine sediment is associated with _______. What does it mean? May see ______ in the urine
A
nephrotic spectrum of CKD
Bland= no cells or casts
may see oval fat bodies
3
Q
HTN
oliguria
cola-colored urine
What am I?
A
nephritic syndrome
4
Q
hypoalbuminemia
hyperlipidemia
peripheral edema
massive proteinuria
What am I?
A
nephrotic syndrome
5
Q
What is the MC cause of primary glomerulonephritis?
A
berger’s dz ( IgA nephropathy)
6
Q
What are the 5 causes of glomerulonephritis?
A
C3 glomerulopathy
Anti-glomerular basement membrane
Monoclonal Ig
Pauci-immune
Immune complex deposition
7
Q
What is happening in Immune complex deposition GN? What is the MC cause?
A
Antigen-antibody complexes lodge in glomerular basement membrane (GBM)
Complement activation to resolve complexes → GBM destruction
**IgA nephropathy (Berger disease)- MC
Infections
endocarditis
LUPUS
Strep!
8
Q
What is happening in Anti-GBM-associated glomerulonephritis? _______ is a type of anti-GM. What systems does it involve?
A
Autoantibodies against GBM
Goodpasture’s Syndrome
kidneys and lungs
9
Q
What is happening in C3 Glomerulopathy ? What is it caused by?
A
C3 complement proteins lodge in the glomerular basement
membrane (GBM) → GBM destruction
aka C3 gets stuck and activate and destroys GBM
Causes - abnormal alternative complement pathway
10
Q
What is happening in Monoclonal Ig-mediated glomerulonephritis? What is it caused by?
A
Excessive antibodies lodge in GBM and/or tubular basement membrane
causes monoclonal gammopathies (multiple myeloma, MGUS)
11
Q
What is MGUS? What type of GN is it associated with?
A
monoclonal gammopathy of unknown significance, B cells that make antibody
12
Q
What is happening in Pauci-Immune Glomerulonephritis? What is it caused by? What is important to note?
A
small-vessel vasculitis associated with ANCAs
cell-mediated autoimmune processes
CELL MEDIATED!!
13
Q
What are some common PE findings in GN?
A
GFR decreases
edema in scrotal and periorbital regions
cola-colored urine
14
Q
If a pt has GN, what will their BUN:Cr ratio be? What will their urinalysis look like? Urine sediment?
A
BUN:Cr ratio will be higher than 20
hematuria, moderate proteinuria (usually LESS 3 g/d)
RBC (often dysmorphic), RBC casts
15
Q
What are RBC casts a sign of? What type of kidney injury are they associated with?
A
sign of heavy glomerular bleeding, tubular stasis
GN
16
Q
When would it be common to see low complement levels in what types of GN? What is the exception?
A
complement levels are low in C3 complex and Immune complex GN (except Berger’s dz)
Immune complex GN (except Berger’s dz)
17
Q
When would you order an renal biopsy in GN? What are the CI?
A
to find the underlying cause by revealing the patten of inflammation related to the cause if it is not CI
CI: bleeding disorder and uncontrolled HTN
18
Q
What is the tx for GN?
A
Management of HTN
Management of volume overload - if present
Antiproteinuric therapy (ACE/ARB) - NOT IN AKI GN
steroids
cytotoxic agent
plasma exchange for Goodpasture dz and P Pauci-immune glomerulonephritis
19
Q
What 2 types of GN do you treat with plasma exchange?
A
Pauci-immune glomerulonephritis
Goodpastures dz (Anti-GBM)
20
Q
Postinfectious Glomerulonephritis is usually due to ______. What will the serum blood test reveal? What will the urine show?
A
GABHS
Low complement; high ASO titer (unless previous abx)
hematuria, subnephrotic proteinuria (<3 g/d), RBC casts
21
Q
_____ helps definitive dx of Postinfectious Glomerulonephritis. What will it reveal? What is the tx?
A
Biopsy
“humps” of immune complex deposits
PCN, antihypertensives, salt restriction, diuretics
22
Q
What should you NOT give in Postinfectious Glomerulonephritis? Why?
A
steroids
do NOT improve outcomes
23
Q
_______ is the MC PRIMARY glomerular dz worldwide. What is the common pt population?
A
IgA Nephritis (Berger’s Disease)
2-3x more common in males; MC in children and young adults
24
Q
How does Berger’s dz commonly present?
A
episode of gross hematuria often with an viral URI
25
What is the serum test you would want to order to confirm berger's dz? What will the urinalysis look like?
there is NO confirming test
hematuria (micro or gross), proteinuria (varies)
26
What is the tx for berger's dz? low risk and high risk
Low risk - no HTN, normal GFR, minimal proteinuria - monitor yearly
High risk - proteinuria >1.0 g/d, decreased GFR, HTN - ACE or ARB
27
What is Henoch-Schönlein Purpura? What is the MC pt population?
Systemic small-vessel vasculitis, with IgA deposition in vessel walls
MC in males and children
28
_______ is the MC systemic vasculitis of childhood.
Henoch-Schönlein Purpura
29
What is the serum test you would want to order to confirm Henoch-Schönlein Purpura? What is the normal presenation?
No confirming serum test!
Palpable purpura in lower extremities and butocks; arthralgias, abdominal symptoms (nausea, colic, melena)
30
What is the tx for Henoch-Schönlein Purpura?
no specific tx, supportive care
31
In US _____ is MCC of nephrotic glomerular disease. What is the proteinuria range? ______ is a very common PE finding
DM
GREATER than 3 grams/day
peripheral edema!!, dyspnea, pleural effusions, ascities
32
______ test only detects albumin so need to order ______ and/or _______ in nephrotic syndrome. Which one is the most accurate?
urine dipstick
Spot urine protein:urine Cr ratio
24-hr urine for protein- more accurate
33
What will the urine sediment show in nephrotic syndrome? If marked HLD will show ________
few cells/casts
“Grape clusters” (light microscopy)
“Maltese crosses” (polarized light)
oval fat bodies
34
What will serum labs show for a pt who has nephrotic syndrome?
hypoalbuminemia
hypoproteinemia
hyperlipidemia
elevated ESR
decreased levels of Vit D, zinc and copper
35
Why is hyperlipidemia seen in greater than 50% of nephrotic syndrome pts?
low protein due to peeing it all out decreases oncotic pressure which increased hepatic lipid production
and lower clearance rate of VLDL leads to hypertriglyceridemia
36
______ is done in adults with new-onset idiopathic nephrotic syndrome but NOT done if DM or another obvious cause is present
renal biopsy
NOT done in real life
37
if nephrotic syndrome is mild ______ dietary protein. If greater than 10mg protein lost per day need to _______ dietary protein
mild restrict protein intake
greater than 10mg protein lost per day need to increased protein consumption
38
What are the medication tx options for nephrotic syndrome?
1st- ACE/ARB
2nd- SGLT2 inhibitors (-flozin)
3rd- Nonsteroidal mineralocorticoid receptor antagonists (nsMRAs) (finerenone)
- MRAs: eplerenone, spironolactone would be next best option if finerenone is not covered
thiazide and loops in large doses
statins to reduce hyperlipidemia
anticoags
39
Why do you give an ACE/ARB in nephrotic syndrome?
lower urine protein excretion by reducing glomerular capillary pressure; antifibrotic effects
40
Why would you give a SGLT2 inhibitor in nephrotic syndrome?
lower urine protein excretion by lowering intraglomerular pressure (tubuloglomerular feedback), reducing renal oxidative stress and improving oxygenation of cortex
41
Why would you give a Nonsteroidal mineralocorticoid receptor antagonists (nsMRAs) in nephrotic syndrome? What is the drug name specifically? What are the alternatives?
reduce effects of aldosterone, lowering intraglomerular pressure and therefore proteinuria
finerenone (Kerendia)
eplerenone, spironolactone just normal mineralocorticoid receptor antagonists (MRAs)
42
_____ is a common PE finding in nephrotic syndrome. How do you tx it?
edema
dietary salt restriction and thiazide and loop diuretics at high doses
43
What is the tx for hyperlipidemia in nephrotic syndrome?
diet and exercise with lipid-lowering drugs
44
When is hypercoagulability seen in nephrotic syndrome? Why? What does it lead to? What is the tx?
Usually seen if serum albumin <2 g/dL
because increased urinary loss of antithrombin, protein C, protein S
leads to increased platelet activation
tx: anticoag for 3-6 months if evidence of thrombosis and need to be for life if multiple clots are present
45
**_______ is the MC cause of proteinuric renal dz in children. What are the s/s?
Minimal Change Disease
often full-blown nephrotic syndrome
Thromboembolic events, hyperlipidemia, protein malnutrition
46
What is the tx for minimal change dz? How long do you continue tx in children and adults?
high dose Prednisone, 60 mg/m2/d
8 weeks in kids and 16 weeks in adults
need to taper dose after course is complete
47
**_______ is the MC cause of PRIMARY nephrotic syndrome in adults. What is the caused by?
Membranous Nephropathy
immune complex deposition
48
_______ may be secondary to carcinoma, HBV, HCV, syphilis, endocarditis, autoimmune disease, NSAIDs, captopril
membranous nephropathy
49
membranous nephropathy PE findings may be ______, ______ and _____. What are they at an increased risk for?
asymptomatic; may see edema, frothy urine
Higher risk of hypercoagulable state, esp. renal vein thrombosis
50
What is the tx for membraneous nephropathy?
ACE/ARB
immunosuppressive agents
kidney transplant
51
______ is a type of secondary nephrotic syndrome that occurs as a result of extracellular deposits of ______ protein. When visualizing the kidneys that are often ______. Why?
Amyloidosis
amyloid protein
large kidneys due to protein deposits that are very big
52
What is the tx for amyloidosis? What is the prognosis?
very limited options, manage underlying dz
Overall 5-year survival - <20% soooo NOT GREAT
53
______ is the MC cause of ESRD in the US. Is it primary or secondary?
diabetic nephropathy
secondary nephrotic syndrome
54
When does Diabetic Nephropathy usually develop after the dx of DM? What does early and later diabetic nephropathy look like lab wise? When do you need to tx it? What is the tx?
usually develops about 10 years after DM onset
Early - hyperfiltration with increased GFR
Later - microalbuminuria (30-300 mg/d)
Progression - albuminuria 300+ mg/d
Treatment - as soon as microalbuminuria is found!!!
tx: strict gylcemic control
ACE/ARB
SGLT2
55
_____ changes happen before _____ changes
urine changes happen before blood changes
when thinking about changes in lab values
56
Define Focal Segmental Glomerular Sclerosis (FSGS)? Is it a common cause of _______
some, but not all (focal) glomeruli are scarred, and each involved glomerulus is only partially scarred (segmental)
nephrotic syndrome
57
What are some primary causes of Focal Segmental Glomerular Sclerosis (FSGS)?
Idiopathic; associated with cytokines, other glomerular conditions (IgA nephropathy, minimal change disease)
58
Give the genetic reasoning behind Focal Segmental Glomerular Sclerosis (FSGS)?
associated with specific mutated genes resulting in malformed proteins that reduce the integrity of the glomerular filtration barrier
59
What are some secondary causes of Focal Segmental Glomerular Sclerosis (FSGS)? What are the 2 highlighted ones from lecture?
analgesics, **heroin**, lithium, steroids, chemo
HBV, HCV, HIV, Parvovirus B19, CMV, SARS-CoV-2, solitary kidney, vesicoureteral reflux, **obesity**, sickle cell, HTN, Alport syndrome, Sarcoidosis
heroin and obesity
60
How do you definitively dx FSGS? Can suspect FSGS with _____ and _______
renal bx!!
proteinuria and probable cause
61
What is Tubulointerstitial Disease? What is NOT involved?
Disorders mainly affecting renal tubules and interstitium
Glomeruli and renal vessels are relatively spared
62
70% of acute interstitial nephritis is due to ______. How does it present?
medications!!
acute renal failure: reduced urine output, SOB, swelling, fatigue, confusion, HTN, arrthymias etc etc
63
What are the two main pathologies of chronic Tubulointerstitial Disease?
interstitial fibrosis and tubular atrophy
64
What is the MC cause of chronic tubulointerstitial dz?
obstructive uropathy due to kidney stones, prostate dz, cancer of cervix, colon or bladder, retroperitoneal tumors/fibrosis
65
What is the 2nd MC cause of chronic tubulointerstitial disease? What is it?
Vesicoureteral Reflux
urine flow back up the tubule when voiding
66
Analgesic Nephropathy is what type of kidney disease? What is the about you need to consume a day to put yourself at risk?
Chronic Tubulointerstitial Disease
ingest min 1 g/d for 3+ yrs
67
What are the 5 categories of Chronic Tubulointerstitial Disease?
Obstructive Uropathy
Vesicoureteral Reflux
Analgesic Nephropathy
Autoimmune Interstitial
Nephritis
Nephrocalcinosis
68
What are some potential causes of obstructive uropathy?
enlarged prostate, renal calculi, cancer, retroperitoneal fibrosis or mass
69
in obstructive uropathy ______ are almost always asymptomatic. How do you dx?
hydronephrosis
imaging!!! US is preferred then CT for more detailed info. CT is NOT first line
70
How will an obstructive uropathy present?
oliguria, anuria or polyuria if urine is unconcentrated due to damage caused by the tubules
UA: benign, may see hematura and pyuria
serum creatinine may be elevated
71
If you suspect a nephrocalcinosis: what is the imaging of choice?
US
Can also be visualized with CT
72
What is the tx for an obstructive uropathy? Will the pt regain normal function?
find and remove obstruction ASAP!!!
will NOT restore renal function or stop progression to ESRD because the damage has already occured!
73
Vesicoureteral Reflux primarily occurs during ______. ______ sphincter is damaged. What is the common presentation?
childhood
vesicoureteral sphincter
frequent UTIs especially in young children!! HTN and proteinuria in adults
74
________ are very helpful in dx Vesicoureteral Reflux because xrays are taken while the pt is urinating. ______ will show hydronephrosis and renal scarring. Will the kidneys be larger or smaller?
Voiding cystourethrogram
US
asymmetric small kidneys due to scarring and atrophy
75
What is the tx for Vesicoureteral Reflux?
maintain sterile urine -> low dose abx
surgical reimplantation of ureters in kids
control of HTN- ACE/ARB
76
Analgesic Nephropathy was especially associated with ______. Name 3 additional meds that can cause this. What dose?
phenacetin
ASA, NSAIDs, acetaminophen
Ingestion of at least 1 g/d for 3+ years
77
Why is taking too much analegesics bad for your kidneys?
Tubulointerstitial inflammation and papillary necrosis. Analgesics can be concentrated up to 10x higher in renal papillae than in renal cortex
78
_____ may be found in the urine of a pt with Analgesic Nephropathy. What are common CT findings?
Sloughed papillae
small, scarred kidney with papillary calcifications
79
What is IVP? Why is it not used more? What will you find on a pt with Analgesic Nephropathy?
Intravenous Pyelogram: imaging test that uses contrast dye used to look at the kidneys and ureters.
because the contrast is VERY bad for the kidneys
“ring shadow” or “golfball on a tee” sign
80
What is the tx for analgesic nephropathy?
stop taking analgesic
Renal function may stabilize or mildly improve if analgesic stopped in a timely manner
81
What is Autoimmune Interstitial Nephritis
due to?
multiple AI disorders!
Amyloidosis
Cryoglobulinemia
IgA nephropathy
Renal transplant rejection
Anti-GBM-Antibody syndrome (Goodpasture syndrome)
Sarcoidosis
Sjogren Syndrome
SLE
82
Polyuria, decreased urinary concentrating ability
Volume depletion due to salt-wasting
Hyperkalemia
Hyperchloremic metabolic acidosis
What am I?
What will imaging look like?
What is the tx?
Autoimmune Interstitial Nephritis
small, scarred kidneys
control the underlying AI cause
83
What is nephrocalcinosis? What does it cause?
Deposition of calcium in renal parenchyma and tubules
can cause AKI, CKD or do not cause any harm at all!
most do NOT progress to ESRD
84
What is nephrocalcinosis caused by? What is the MC cause?
Caused by increase in urinary excretion of calcium, phosphate, and/or oxalate
MCC - increased urinary calcium excretion
85
having _____, ______ and ______ increases your risk of nephrocalcinosis
hyperparathyroid
vit D therapy
high dose loop diuretics for a long time
86
What is the imaging of choice for Nephrocalcinosis? What is the tx?
US
correct underlying metabolic disorder
87
______ is 65-70% of all renal masses. Where are they usually found?
single renal cyst
Generally in outer cortex, may be in medulla
renal size will be normal and usually asympotmatic
88
If you do find a renal cyst, need to reference the _____ score. When would finding one be a problem?
Bosniak score
If develop after onset of dialysis → potential for adenocarcinoma
89
when Medullary Cystic Kidney Disease
is dx in childhood, what is it called? How is it inherited?
Juvenile Nephronophthisis
autosomal recessive
90
How is adult Medullary Cystic Kidney Disease inherited? Where are the cysts located?
autosomal dominant
multiple small renal cysts at corticomedullary junction and in medulla
91
Polyuria
pallor
lethargy
renal salt wasting
HTN in later dz
hyperuricemia
What am I?
What is the tx?
Medullary Cystic Kidney Disease
adequate salt and water intake
no meds to STOP progression
can give allopurinol if pt is hyperuricemic
RENAL TRANSPLANT
92
How common is Autosomal Dominant Polycystic Kidney Disease (ADPKD)? 90% are from _______ inheritance. 10% from ______
affects 1 in 400 to 1 in 1000 pts
90% from autosomal dominant inheritance
10% from spontaneous mutations
93
What 2 genes are associated with Autosomal Dominant Polycystic Kidney Disease (ADPKD)? Which one is worse?
ADPKD-1 - 85% of pts - more severe course
ADPKD-2 - 15% of pts - slower progression, later onset in life
94
abdominal or flank pain
hx of UTI and nephrolithiasis
hx of HTN in >50%
large kidneys
What am I?
What is the imaging of choice?
Autosomal Dominant PKD
US confirms dx; can use CT if unclear
95
In Autosomal Dominant PKD, where are two additional places that is common to see cysts?
liver and spleen
96
What is the tx for ADPKD?
Tolvaptan (Jynarque, Samsca)- to slow renal decline
ocreotide: decreased cyst growth; no improvement of kidney function
avoid caffeine
2L/water a day
HTN tx and protein RESTRICT
97
In ADPKD may see hematuria due to ______. These pts are at a higher chance of ______. They also have ____ and ____ complications
rupture of cyst
Cerebral aneurysms in the circle of willis
heart: mitral valve prolapse, aortic aneurysms, aortic valve disease
GI: colonic diverticula
98
What should you do if ADPKD pt has an infected cyst? What will it present like?
Blood/urine culture and maybe CT to help dx:
tx with abx: bactrim or fluoroquinolones
flank pain, fever, ↑ WBC
99
______ tx for ADPKD slows rate of change in kidney volume, lower rate of renal decline. What is the drug class? What effect does it have on urine osmo?
Tolvaptan (Jynarque, Samsca)
Vasopressin receptor antagonists
Greater reduction in urinary osmolality = greater impairment of cyst growth
100
______ tx for ADPKD decreased cyst growth; no improvement of kidney function
Ocreotide
101
thirst/polydipsia, polyuria/nocturia, hypernatremia, increased liver enzymes are the SE of ______. What is the BBW? What do you need to monitor?
tolvaptan
should be initiated and reinitiated in patients only in a hospital where serum sodium can be closely monitored
monitor LFTs and electrolytes
102
What part of the kidney does Autosomal Recessive PKD effect? What is the common pt population?
Enlarged kidneys with small cysts on collecting tubules only
commonly first found in neonates
103
Enlarged kidneys (bilateral abdominal masses)
Impaired urine concentration
Metabolic acidosis
HTN common
What am I?
Autosomal Recessive PKD
104
Autosomal Recessive PKD up to 50% of neonates die from ______. ____ of surviving neonates live to ____ or longer but 1/3 will develop ____ by age 10. And may develop ______
pulmonary hypoplasia
80%
age 10
ESRD
portal hypertension from periportal fibrosis
105
How do you dx Autosomal Recessive PKD?
large, echogenic kidneys (kidney that appears bright on an US)
cysts are only visible after birth
106
How do you distinguish ARPKD from ADPKD? What is the tx for ARPKD?
absence of renal cysts in either parents = autosomal recessive
manage HTN, dialysis and kidney transplant
107
80-90% of renal artery stenosis is due to ______. 10-15% is due to _______
atherosclerotic occlusive disease
fibromuscular dysplasia
108
What is fibromuscular dysplasia? What is the classic pt?
Fibromuscular dysplasia (FMD) affects the artery walls, making them either too weak or too stiff making them narrow or bulge
HTN in females who are less than 40
109
_____ of all pts with HTN have RAS. Who are the MC pts?
5%
MC - >45 yrs with atherosclerotic disease hx
110
What is the MC PE finding for a pt with renal artery stenosis? What is the gold standard imaging of choice? What is the real world answer?
HTN!! may have audible abdominal bruit
Renal angiography
Doppler US
111
If a pt gets an AKI after starting an ACE inhibitor, what are you thinking?
renal artery stenosis
112
What is the tx for renal artery stenosis?
meds for HTN and surgery (but NOT proven better than medical management)
angioplasty or stenting
113
What is nephrosclerosis?
Hypertensive nephropathy Sclerosis of arteries and arterioles
Interstitial fibrosis and decreased glomerular tuft
114
What are risk factors for nephrosclerosis? What is the major one? What is the tx?
**African American race - 5x more common**
Increased age, smoking, hypercholesterolemia
Longstanding uncontrolled HTN
tx the HTN!!! thiazides and ACE/ARB
115
What is Cholesterol Atheroembolic Disease? When does it usually occur?
Emboli to kidneys → usually due to cholesterol
crystals breaking free of vascular plaque and lodging in downstream microvessels
following some sort of event: vascular surgery, trauma, heparin, thrombolytics
116
What are the risk factors for Cholesterol Atheroembolic Disease?
male, DM, HTN, ischemic cardiac disease
117
May see livedo reticularis and localized gangrene. What kidney disease are these associated with?
Cholesterol Atheroembolic Disease
118
How do you definitively dx Cholesterol Atheroembolic Disease? What is the tx? What will the labs look like?
kidney biopsy
statins to stabilize the plaque and supportive care
increased Cr, eosinophilia (60-80%), elevated ESR, low complement
119
