CKD and Complications Flashcards
What is the definition of anemia of CKD?
hemoglobin <13g/dL (males) or <12 (females)
What are the four goals of therapy for anemia of CKD?
increase oxygen-carrying capacity, improve quality of life, prevent/alleviate symptoms and complications of anemia, and decrease the need for blood transfusions
At what GFR does anemia generally begin?
<45 mL/min
The redistribution of drug from tissue stores makes TDM unreliable during what phase?
post-dialysis equilibrium
What is the most common cause of erythropoietin resistance?
iron deficiency
How often should an iron panel be done in ESRD patients?
every 3 months
What are the two goals of iron deficiency therapy?
Tsat > 30%, serum ferritin >500 ng/mL
What are side effects of oral iron therapy?
GI upset, dark stools, many drug interactions
What are side effects of IV iron therapy?
INFECTIONS, dyspnea/wheezing, myalgias, hypotension, flushing edema, chest pain, injection site reactions
What forms of oral iron therapy have the most and least percent elemental iron?
most = polysacccharide iron and ferric citrate, least = ferrous sulfate
What is the dosing regimen for most oral iron therapies? Why?
once daily or every other day; decreases the rise in hepcidin
ferric gluconate brand name, iron content and dosing?
Ferrlecit, 12.5, 125mg TIW x 8 doses
iron sucrose brand name, iron content and dosing?
Venofer, 20, 100mg 1-3x weekly
Iron dextran brand name, iron content and dosing?
Dexferrum, 50, 50-100mg q week x10 weeks
LMW iron dextran brand name, iron content and dosing?
InFed, 50, 50-100mg q week x 10 weeks
Ferumoxytol brand name, iron content and dosing?
Feraheme, 30, 510mg x2 3-8 days apart