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Pharmacotherapeutics > CKD anc Complications > Flashcards

CKD anc Complications Flashcards

1
Q 
Glomerular filtration rate classification
G1
G2
G3a
G3b
G4
G5
A

G1 (normal or high): >=90 mL/min
G2 (mildly decreased): 60-89 mL/min
G3a (mildly to moderately decreased): 45-59 mL/min
G3b (moderately to severely decreased): 30-44 mL/min
G4 (severely decreased): 15-29 mL/min
G5 (kidney failure): <15 mL/min

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2
Q

Albuminuria classification
A1
A2
A3

A

A1 (normal): <30 mg/day
A2 (microalbuminuria): 30-300 mg/day
A3 (macroalbuminuria): > 30mg/day

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3
Q

Top four causes of CKD in US

A

Diabetes
Hypertension
Glomerulonephritis
Polycystic kidney disease

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4
Q

Risk factors of CKD progression

Both modifiable and non modifiable

A

Modifiable: Diabetes, HTN, Proteinuria, Hyperlipidemia, Tobacco use, Systemic inflammation, Environmental exposures (heavy metals)

Non modifiable: Older age, African-American or Native American ethnicity, Genetics (family history), Gender

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5
Q

A1C target in CKD for intensive blood glucose control

A

<= 7

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6
Q 
What is the goal for CKD therapy? Choice
- Increase kidney function
- Stop the decline in kidney function 
- Slow the decline in kidney function
How?
A

SLOW the slope of decline, not stop nor increase

Through intensive blood glucose control

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7
Q

First line agents for lowering BP in CKD patients?

A

ACE-I or ARB medications

ACEi: -pril
ARB: -sartan

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8
Q

What is the target BP for a patient with albuminuria and CKD? Without albuminuria?

A

<130/80 regardless

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9
Q 
Non-dihydropyridine Calcium Channel Blockers
Medication name:
Effect:
Side effect:
Drug interaction:
A
  • Medication name: verapamil, Diltiazem
  • Effect: anti proteinuria effects (dilate afferent arteriolar), negative inotropes and chronotropes
  • Side effects: negative inotropes and chronotropes
  • Drug interaction: a lot, do not use with beta blockers
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10
Q

Dihydropyridine CCBS

  • Medication name
  • Effects
  • Side effects
  • Drug interaction
A
  • Medication name: amlodipine, nifedipine
  • Effect: no effect on proteinuria
  • Side effects: risk of worsening edema
  • Drug interaction
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11
Q

Antihypertensive Drug selection in CKD

A
  1. ACEi or ARB: titration to maximal dose for anti proteinuric effect
  2. Thiazides diuretics.
    • If clinically evident edema — use loop diuretics
  3. Calcium channel blocker
    • Non DHP (diltiazem) for additional anti proteinuric effects
    • DHP for additional BP reduction
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12
Q

Non pharmacologic treatment for CKD patients?

A

Low sodium intake <2g/day
Moderate intensity exercise regimen
Weight loss to a BMI of 20-25 kg/m2
Limit alcohol intake to <= 2 drinks per day for males and <= 1 drink per day for females

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13
Q

Should we start statin in CKD pt with hyperlipidemia? In CKD dialysis? In CKD non dialysis? Dose adjustment?

A

Start statin in CKD non dialysis pt as it benefits for all causes mortality as well as cardiovascular events

Don’t start statin in CKD dialysis pt or might consider continue if pt is already on statin,
UNLESS the CKD dialysis pt also in acute coronary syndrome, then can use statin acutely (first 30-90 days)

There is no dose adjustment needed

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14
Q 
Which is a first line antihypertensive drug for a patient with albuminuric CKD?
Hydrochlorothiazide
Diltiazem
Enalapril
Amlodipine
A

Hydrochlorothiazide — thiazides diuretics (second line of choice)
Diltiazem — non DHP CCBs for additional anti proteinuric effect
Enalapril — ACEi, first line of choice
Amlodipine — DHP CCBs for additional blood pressure reduction

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15
Q 
A patient has an estimated GFR of 43ml/min/1.73m2 and a urinary albumin excretion of 225mg/g creatinine. What best categorizes their CKD?
G3a, A2
G3a, A3
G3b, A2
G3b, A3
A

G3b, A2

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16
Q

What is the goal of albumin excretion in diabetic CKD management?

A

Reduce proteinuria to minimum possible; 30-50% reduction

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17
Q

Benazepril

A 
Brand name: Lotensin
Starting dose: 5mg daily
Maximum dose: 80 mg daily
FDA indications: HTN
Duration of action: 24 hours
Elimination: 60% renal, 40% biliary
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18
Q

Captopril

A 
Brand name: Capoten 
Starting dose: 12mg TID
Maximum dose: 150mg TID
FDA indications: HTN, HFrEF, LV dysfunction
Duration of action: 6-10 hours
Elimination: 50% renal, 50% hepatic
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19
Q

Enalapril

A 
Brand name: Vasotec
Starting dose: 2.5mg daily
Maximum dose: 10mg BID or 20mg daily
FDA indications: HTN, HRrEF, LV dysfunction
Duration of action: 12-24 hours
Elimination: 94% renal
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20
Q

Fosinopril

A 
Brand name: Monopril
Starting dose: 10mg daily
Maximum dose: 40mg daily
FDA indications: HTN, HFrEF
Duration of action: 24 hours
Elimination: 50% renal, 50% biliary
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21
Q

Lisinopril

A 
Brand name: Zestril, Prinivil
Starting dose: 5mg daily
Maximum dose: 80mg daily
FDA indications: HTN, HFrEF
Duration of action: 24 hours 
Elimination: 100% renal
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22
Q

Moexipril

A 
Brand name: Univasc
Starting dose: 3.75 mg daily
Maximum dose: 30 mg daily
FDA indications: HTN
Duration of action: 24 hours
Elimination: 7% urine, 52% feces
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23
Q

Quinapril

A 
Brand name: Accupril
Starting dose: 5mg daily
Maximum dose: 80mg daily
FDA indications: HTN, HFrEF 
Duration of action: 24 hours 
Elimination: 96% renal
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24
Q

Ramipril

A 
Brand name: Altace
Starting dose: 1.25mg daily
Maximum dose: 20mg daily
FDA indications: HTN, HFrEF
Duration of action: 24 hours
Elimination: 60% renal, 40% feces
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25
Q

Trandolopril

A 
Brand name: Mavik
Starting dose: 1mg daily
Maximum dose: 4mg daily
FDA indications: HTN, LV dysfunction
Duration of action: 24 hours 
Elimination: 33% urine, 66% feces
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26
Q

Azilsartan

A 
Brand name: Edarbi
Starting dose: 40mg daily
Maximum dose: 80mg daily
FDA indications: HTN
Duration of action: 24 hours
Elimination: 55% feces, 42% urine
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27
Q

Candesartan

A 
Brand name: Atacand
Starting dose: 4-8mg daily
Maximum dose: 32mg daily
FDA indications: HTN, HFrEF
Duration of action: 24 hours 
Elimination: 65% hepatic, 35% renal
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28
Q

Eprosartan

A 
Brand name: Teveten
Starting dose: 600mg daily
Maximum dose: 800mg daily
FDA indications: HTN
Duration of action: 12-24 hours 
Elimination: 90% feces, 7% urine
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29
Q

Irbesartan

A 
Brand name: Avapro
Starting dose: 75-150mg daily
Maximum dose: 300mg daily
FDA indications: HTN, Diabetic nephropathy
Duration of action: 24 hours
Elimination: 80% hepatic, 20% renal
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30
Q

Lorsartan

A 
Brand name: Coozar
Starting dose: 25-50 mg daily
Maximum dose: 100-150mg daily
FDA indications: HTN, LVH, Diabetic nephropathy
Duration of action: 24 hours
Elimination: 60% feces, 40% urine
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31
Q

Olmesartan

A 
Brand name: Benicar
Starting dose: 20mg daily
Maximum dose: 50mg daily
FDA indications: HTN
Duration of action: 24 hours
Elimination: 50% feces, 50% urine
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32
Q

Telmisartan

A 
Brand name: Micardis
Starting dose: 20mg daily
Maximum dose: 80mg daily
FDA indications: HTN, CV risk reduction
Duration of action: 24 hours 
Elimination: 97% feces
33
Q

Valsartan

A 
Brand name: Diovan
Starting dose: 1.25mg daily
Maximum dose: 20mg daily
FDA indications: HTN, HFrEF, LV dysfunction
Duration of action: 24 hours 
Elimination: 83% feces, 13% urine
34
Q

Aliskiren

  • Brand name
  • MOA
  • Efficacy
  • Contraindications
A 
Brand name: Tekturna
MOA: Direct renin inhibitor 
Dosing: 150-300mg PO once daily
Efficacy: Reduces proteinuria and BP
Contraindications: pregnancy, combination with ACEi or ARB
35
Q

Goals of RAAS Inhibitors

A
  1. BP < 130/80 mmHg
  2. Reduction in albuminuria by 30-50%
  3. Slow progression of CKD
  4. Adhere to daily dose of medication with minimal AEs
36
Q

RAAS Inhibitor Contraindications

ABSOLUTE Contraindications
Use with caution

A

Absolute Contraindications:

  • Pregnancy
  • Bilateral renal artery stenosis
  • History of ACE/ARB related angioedema

Use with caution:

  • Unilateral renal artery stenosis
  • Hyperkalemia
  • Dehydration / hypovolemia
  • Hypotension
  • Kidney dysfunction (SCr>3.0mg/dL, eGFR<30mL/min/1.73m2)
37
Q

Monitoring of RAAS Inhibitors

A

Side effects:
Hyperkalemia and decrease GFR
- Closely monitor the SCr and serum potassium
- As long as the decline in GFR doesn’t go above 30%
Orthostatis, Angioedema, Cough

Adverse effects:

  • Hypotension/ orthostasis/ dizziness
  • Cough
  • Hyperkalemia
  • Angioedema
38
Q

What is the main goal of an ACE inhibitor when being used to treat CKD?

  • Reduce cardiovascular events
  • Reduce albuminuria by 30-50%
  • Reduce albuminuria go <130 mg/g creatinine
  • Stop the decline in GFR
A

Reduce albuminuria by 30-50%

Goal is to slow the decline in GFR, surrogate markers of decreased albuminuria (by 30-50%) and blood pressure <130/80 are used to achieve this

39
Q

What is an absolute Contraindications to quinapril?

  • Unilateral renal artery stenosis
  • Serum creatinine of 2.5 mg/mL
  • Pregnancy
  • Blood pressure of 126/78 mmHg
A

Pregnancy

Quinapril is an ACEi

40
Q

A patient with CKD starts lisinopril 10mg PO daily. At baseline their eGFR is 60ml/min/1.73m2 and serum potassium is 4.0 mEq/L. Two weeks after initiation their eGFR is 48mL/min/1.73m2 and serum potassium is 4.5mEq/L. What should be done at this point given these new labs?

  • Continue current lisinopril dose; re-check labs in 2-4 weeks
  • Increase lisinopril dose to 20mg PO daily; re-check labs in 1-2 months
  • Decrease lisinopril dose to 5mg PO daily; re-check labs in 1-2 days
  • Hold lisinopril; re-check labs in 1 weeks
A

Continue current lisinopril dose; re-check labs in 2-4 weeks

eGFR declined by ~20%, which does not meet the 30% threshold for action. Would re-check labs to ensure the eGFR doesn’t drop further. This is an expected change in eGFR when starting an ACEi or ARB. Potassium remains WNL so no intervention needed there.

41
Q

What are the benefit of SGLT2 inhibitors? And what is it used for?
What are the adverse effects?

A
  • gliflozin
    Slows progression of kidney disease in patients with or without diabetes, reduce cardiovascular morbidity and mortality

Used as a second line treatment option for T2DM and CKD

Adverse effects:

  • Acute kidney injury
  • Euglycemic diabetic ketoacidosis
  • Urinary tract infections/ genital mycotic infections
  • Lower limb amputations
42
Q

Allopurinol and Febuxostat

Used:
Goal:

A
  • Decreased uric acid generation
  • Goal uric acid in CKD <7mg/dL
  • Allopurinol has been shown to slow CKD progression and improved cardiovascular outcomes
  • Allopurinol Hypersensitivity syndrome
    • Systemic hypersensitivity, including Stevens-Johnson Syndrome, renal and hepatic injury
  • Dosing: 1.5 mg x eGFR
43
Q

Alkali Therapy: Sodium Bicarbonate

  • Used
  • Goal
A

Use sodium bicarbonate to manage chronic metabolic acidosis, may also slow regenerating of CKD (but not much evidence on this)
- Target serum bicarbonate is 20. When it’s below 20, start sodium bicarbonate or sodium citrate. When it’s above 20 (goal), can start to decreasing the dose, but likely need some chronic bicarbonate supplementation because the kidney is not regenerating like it does normally

44
Q

SGLT2 inhibitors slow progression of CKD in both diabetic and non-diabetics
True
False

A

True

- DAPA CKD trial showed better renal outcomes in DM and non-DM populations

45
Q 
What non-pharmacologic intervention is recommended to slow CKD progression?
High protein diet
Low potassium diet
Achieve a healthy BMI (20-25kg/m2)
No more than 3 alcoholic drinks per day
A

Achieve a healthy BMI (20-25 kg/m2)

Other include:

  • Reduce dietary proteins as CKD worsens (<=0.8 g/kg/day)
  • Na< 2g/day, NaCl <5 g/day
  • Limited alcohol intake (female 1 drink per day, male 2 drinks per day)
  • Smoking cessation
  • Goal BMI <25 kg/m2 (weight loss strategy includes exercise — 4 to 5 days a week for 30 minutes a session)
46
Q

Definition of Anemia in CKD

A

HGB<13 g/dL in males

HGB<12 g/dL in females

47
Q

Goals of therapy of Anemia of CKD

A
  1. Increase oxygen carrying capacity
  2. Improve quality of life
  3. Prevent / alleviate symptoms and complications of anemia
  4. Decrease need for blood transfusions
    The goal does not include mortality rate
48
Q

Target HGB (hemoglobin) range in Anemia

A

10-11 g/dL

-Oxygen carrying capacity of RBCs

49
Q

Serum Ferritin target range in Anemia? What does it do?

A

> 100 ng/mL CKD 1-4
500 ng/mL ESRD

  • Storage form of iron
  • Normal Range: >10-20 ng/mL
50
Q

Transferrin Saturation target range in Anemia, and what does it do?

A 
Transferrin Saturation (Tsat)
>30%
  • Reflects iron available for immediate erythroposiesis
  • Normal Range: (M) 15-50%, (F) 12-45%
51
Q

The most common causes of Erythropoietin resistance

  • What is this
  • Therapeutic response
  • Goal
A

Iron deficiency

  • Must correct this first
  • Iron panel should be monitored every 3 months in an ESRD pt or anyone receiving erythropoietin for anemia
  • Therapeutic response
    • Increased Reticulocyte count within 7-14 days
    • Increased HGB and HCT within 3-4 weeks
  • The goal is to obtain Tsat >30% and serum ferritin >500 ng/mL
52
Q

Oral vs Parenteral Iron Therapy

A

Oral: Poor absorption (10% -15% bioavailability), GI complications (nausea, cramping, constipation), poor adherence, slow replenishment of iron stores
- Side effects include GI upset and dark stool

Parenteral: Better absorption, rapid replenishment of iron stores, risk of iron overload, infusion reactions, anaphylactic reactions, avoid IM use (variable absorption, painful, bleeding risk)
- Side effects include dyspnea/ wheezing, itching, myalgias, hypotension, flushing, edema, chest pain, cardiac arrest, injection site reactions, anaphylactic and anaphylactic reactions, infections

53
Q

What is the goal transferrin saturation for a hemodialysis patient?
10-11g/dL
30-50%
500-1200ng/mL
2-9 times the upper limit of normal for the assay

A

30-50%

54
Q 
What is a contraindication to intravenous iron therapy?
Active malignancy
Hypertension
Systemic infection
Use of a proton pump inhibitors
A

Systemic infection

55
Q 
Complications of oral iron therapy includes (SATA)
Poor oral absorption
Constipation
Dark colored stool
Intestinal necrosis
A

Poor oral absorption
Constipation
Dark colored stool

56
Q

KDIGO and FDA Guidelines for Initiation of ESAs and Hemoglobin Targets in Non dialysis CKD patients and dialysis patient (ESRD)

A 
Initiation of ESA in ND-CKD
- KDIGO: Hb < 10 g/dL
- FDA: Hb < 10 g/dL
Initiation of ESA in ESRD
- KDIGO: Hb 9-10 g/dL
- FDA: If < 10 g/dL
Target Hb for ND-CKD
- KDIGO: Do not exceed 11.5
- FDA: 10 avoid transfusion 
Target Hb for ESRD
- KDIGO: Do not exceed 11.5
- FDA: 10-11 avoid transfusion
57
Q

Erythropoiesis Stimulating Agents (ESA) Dosing

A

Goal change in HGB: 1-2 g/dL/month

  • Dosing adjustments at 4 weeks (steady state)
  • Reduce ESA dose by >=25% as the patient’s HGB approaches 12g/dL or if HGB increases >1g/dL in 2 weeks or less
  • Increase ESA dose by 25% if HGB is below target after 4 weeks of treatment
58
Q

What is ESA resistance? What causes it?

A

ESA resistance is failure to achieve a target HGB at a dose of >500 units/kg/week (around 5 times higher than normal)

Causes:
Iron deficiency 
ACE inhibitors
Hyperparathyroidism
Aluminum toxicity
Folate and/or Vitamin B12 deficiency
Infection
Malignancy
Trauma
Inflammation
59
Q

Adverse effects of ESA

A 
Hypertension
Hypercoagulability — increased risk of thrombosis (ex: DVT, PE, MI, CVA, etc)
Hypersensitivity reactions
PRBCA (pure red blood cell aplasia)
Headache, fatigue, edema
Progression of malignancy
60
Q

Do not use ESA if:

A

Active malignancy
High risk of CVA
HGB > 11 g/dL

61
Q 
Compared to epoetin alfa, darbepoetin alfa:
Has a longer half life
Is dosed more often
Has a lower risk of stroke
Can be used in several hypertension
A

Has a longer half life

  • All do the ESAs have risks of stroke/HTN, there are Novell declineatd differences between the agents in terms of these outcomes the major differences are duration of action and therefore dosing interval
62
Q 
According to the FDA, a patients with non dialysis CKD should be treated with an ESA to a hemoglobin target of:
10-11 g/dL
10 g/dL
10-11.5 g/dL
>7 g/dL
A

10 g/dL

63
Q

What is an absolute contraindication to the use of an ESA?
History of hypertension, current blood pressure 138/78 mmHg
History of myocardial infarction 5 years ago
Systemic infection
Active malignancy with anticipated cure

A

Active malignancy with anticipated cure

64
Q

Calcium calculation

A

Corrected calcium = measured calcium + 0.8 (4 - albumin)

65
Q

Goal of treatment of CKD-MBD

A
  1. Prevent consequences of cardiovascular and extra vascular calcification
  2. Prevent the development of secondary hyperparathyroidism and renal osteodystrophy
  3. Maintain critical biochemical parameters (calcium, phosphate, and iPTH) within target ranges
  4. Prevent mortality
66
Q

List two calcium based binder

A 
Calcium acetate (PhosLo) — preferred 
Calcium carbonate
67
Q

List 4 non calcium based binder

A 
Sevelamer carbonate (Renvela) — first line
     - Causes diarrhea
Lanthanum carbonate (Fosrenol) — chewable 
Ferric citrate (Auryxia) — iron deficiency anemia 
Sucroferric oxyhydroxide (Velphoro) — pill burden
68
Q

List 4 ways to lower parathyroid hormone
Normal to low serum calcium
Normal to high serum calcium

A

Activated Vitamin D and Analogs:

  • Calcirtriol (Rocaltrol) — Endogenous
  • Paricalcitol (Zemplar); Doxercalciferol (Hectorol) — Less hyperkalemia and less hyperphosphatemia

Calcimimetic

  • Cinacalcet (Sensipar)
  • Etelcalcitide (Parsabiv)
69
Q

Goal for CKD-MBD

A
  • Goal serum Calcium: avoid hyperkcalcemia; asymptomatic hypocalcemia is acceptable
  • Goal serum phosphate: towards the normal range (3.5 - 5.5 mg/dL)
  • Goal iPTH: 2-9 x ULN (~ 150-600 pg/mL)
70
Q

Calcium based phosphate binders drug interactions

A

Fluroquinolones
Levothyroxine
Iron

Separate administration by ~2 hours

71
Q

What is the goal serum phosphorous concentration in a CKD patient?
Avoid hyperphosphatemia, asymptomatic hypophosphatemia is acceptable
Toward the normal range (2.7-4.6mg/dL or 3.5-5.5mg/dL are acceptable)
2-9 times the upper limit of normal for the assay
10-11mg/dL

A

Toward the normal range (2.7-4.6mg/dL or 3.5-5.5mg/dL are acceptable)

72
Q 
A patient with CKD MBD has a serum calcium of 7.7mg/dL, phosphorous of 6.2mg/dL, and albumin of 3.3g/dL. Which phosphate binder should be used?
Calcium acetate
Sevelamer carbonate
Aluminum hydroxide
Sucroferric oxyhydroxide
A

Calcium acetate

  • Low correct serum calcium — use calcium based binders first
73
Q 
When is sucroferric oxyhydroxide most useful?
Iron deficiency anemia
To decrease pill burden
When cost is a barrier to adherence
When the patient is also hypocalcemic
A

To decrease pill burden

74
Q 
A unique side effect of sevelamer is 
GI upset/ nausea
Diarrhea
Dark stools
Kidney stones
A

Diarrhea

75
Q

Role of Vitamin D in a CKD-MBD patient

A

Should be used in …

  • Elevated iPTH despite calcium and phosphate at goal
  • Persistent hypocalcemia with hyperparathroidism

Should not be used in…
- Hypefcalcemia and/or hyperphosphatemia

76
Q

Dosing for Cinacalcet (Sensipar)

A

Extracellular calcium sensing receptors on the parathyroid gland to enhance affinity for extracellular calcium and suppress PTH secretion for treatment of secondary hyperparathyroidism

Dose: 30mg/day orally and titration up every 2-4 weeks to MDD (180mg)
- Based on GI side effects and PTH suppression

Can cause hypoglycemia, treat Ca if <8.4 mg/dL

77
Q 
Compared to paricalcitol, calcitriol 
Causes more hypocalcemia 
Is more expensive
Is more potent to suppress PTH
Requires hepatic activation
A

Causes more hypercalcemica

78
Q 
An ESKD patient has a corrected serum calcium of 10.9mg/dL, phosphate of 4.2mg/dL, and iPTH of 800pg/mL. What medication should be used to treat their MBD?
Calcitriol
Doxercalciferol
Calciferol
Cinacalcet
A

Cinacalcet

  • Correct calcium is slightly high, would want to use a calcimimetic which will actually lower serum calcium. Any vitamin D product will increase serum calcium and worsen their hypercalcemia

Pharmacotherapeutics (1 decks)

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