CKD AB Flashcards
What are 5 causes of EPO resistance?
Infection Inflammation - i.e. surgery Fe deficiency - absolute or functional Severe hyperparathyroid - BM replaced with fibrosis ACE inhibitors
What are the 3 types of renal bone disease?
Adynamic bone disease
Osteitis fibrosa cystica
Low turnover osteomalacia
Name some benefits of PD over HD
Preserve RRF Reduce infectious risk Increased early graft function post Tx Probably less inflammation Decreased EPO/Fe Cheaper Preserve vascular access Even volume and BP control Liberal diet/fluid Incremental start ‘easier' Independence and employment
What patient factors reduce the accuracy of CG equation?
Age >65
Overweight and underweight
Which eGFR calculation is most accurate in the elderly?
CKD-EPI
What are the advantages of CKD-EPI over MDRD and CG?
More accurate with eGFR >60
More accurate in the elderly
What are the advantages of using serum cystatin C as an alternative marker of eGFR?
Less influenced by age, weight, gender and muscle mass
What factors may reduce the accuracy of serum cystatin C measurement?
Thyroid status
Inflammaiton
DM
Corticosteroids
In a patient with IgA nephropathy with a normal serum creatinine, what is the best predictor of developing ESKD?
Level of proteinuria
In a patient with a 5 year history of T2DM, what is the most appropriate screening test for diabetic nephropathy?
Urine ACR
In treatment of proteinuria, is tight glycaemic control or BP lowering more effective?
BP lowering
What treatment options are effective in lowering proteinuria?
ACEi / ARB Lowering BP (better than tight glucose control) Spironolactone - preliminary data Salt restriction Bicarbonate Statins - marginal benefit
